Advanced Photon Counting

Curr Opin Struc Biol 12:634–641 Dertinger T, Ru ̈ttinger S (2014) Advanced FCS: an introduction to fluorescence lifetime correlation spectroscopy and dual-focus FCS. In: Kapusta P et al. (eds) Advanced photon counting: applications, ...

Advanced Photon Counting

This volume focuses on Time-Correlated Single Photon Counting (TCSPC), a powerful tool allowing luminescence lifetime measurements to be made with high temporal resolution, even on single molecules. Combining spectrum and lifetime provides a “fingerprint” for identifying such molecules in the presence of a background. Used together with confocal detection, this permits single-molecule spectroscopy and microscopy in addition to ensemble measurements, opening up an enormous range of hot life science applications such as fluorescence lifetime imaging (FLIM) and measurement of Förster Resonant Energy Transfer (FRET) for the investigation of protein folding and interaction. Several technology-related chapters present both the basics and current state-of-the-art, in particular of TCSPC electronics, photon detectors and lasers. The remaining chapters cover a broad range of applications and methodologies for experiments and data analysis, including the life sciences, defect centers in diamonds, super-resolution microscopy, and optical tomography. The chapters detailing new options arising from the combination of classic TCSPC and fluorescence lifetime with methods based on intensity fluctuation represent a particularly unique highlight.

Advanced Photon Counting

This volume focuses on Time-Correlated Single Photon Counting (TCSPC), a powerful tool allowing luminescence lifetime measurements to be made with high temporal resolution, even on single molecules.

Advanced Photon Counting

This volume focuses on Time-Correlated Single Photon Counting (TCSPC), a powerful tool allowing luminescence lifetime measurements to be made with high temporal resolution, even on single molecules. Combining spectrum and lifetime provides a “fingerprint” for identifying such molecules in the presence of a background. Used together with confocal detection, this permits single-molecule spectroscopy and microscopy in addition to ensemble measurements, opening up an enormous range of hot life science applications such as fluorescence lifetime imaging (FLIM) and measurement of Förster Resonant Energy Transfer (FRET) for the investigation of protein folding and interaction. Several technology-related chapters present both the basics and current state-of-the-art, in particular of TCSPC electronics, photon detectors and lasers. The remaining chapters cover a broad range of applications and methodologies for experiments and data analysis, including the life sciences, defect centers in diamonds, super-resolution microscopy, and optical tomography. The chapters detailing new options arising from the combination of classic TCSPC and fluorescence lifetime with methods based on intensity fluctuation represent a particularly unique highlight.

Advanced Time Correlated Single Photon Counting Techniques

So this reference and text describes how advanced TCSPC techniques work and demonstrates their application to time-resolved laser scanning microscopy, single molecule spectroscopy, photon correlation experiments, and diffuse optical ...

Advanced Time Correlated Single Photon Counting Techniques

In 1984 Desmond O’Connor and David Phillips published their comprehensive book „Time-correlated Single Photon Counting“. At that time time-correlated s- gle photon counting, or TCSPC, was used primarily to record fluorescence decay functions of dye solutions in cuvettes. From the beginning, TCSPC was an am- ingly sensitive and accurate technique with excellent time-resolution. However, acquisition times were relatively slow due to the low repetition rate of the light sources and the limited speed of the electronics of the 70s and early 80s. Moreover, TCSPC was intrinsically one-dimensional, i.e. limited to the recording of the wa- form of a periodic light signal. Even with these limitations, it was a wonderful te- nique. More than 20 years have elapsed, and electronics and laser techniques have made impressive progress. The number of transistors on a single chip has approximately doubled every 18 months, resulting in a more than 1,000-fold increase in compl- ity and speed. The repetition rate and power of pulsed light sources have increased by about the same factor.

Photon Counting Image Sensors

Bulter, A. Single-Photon Counting Detectors for the Visible Range Between 300 and 1000 nm. In Advanced Photon Counting; Springer International Publishing: Cham, Switzerland, 2014; pp. 23–42. Wahl, M. Time Correlated Single Photon ...

Photon Counting Image Sensors

This book is a printed edition of the Special Issue "Photon-Counting Image Sensors" that was published in Sensors

Millimeter Precision Laser Rangefinder Using a Low Cost Photon Counter

Advanced Photon Counting Techniques, 6372, 2006 M.A. Marwick, A.G. Andreou, "Single photon avalanche photodetector with integrated quenching fabricated in TSMC 0.18 um 1.8 V CMOS process," Electronics Lett., 44, 643-644, 2008 C. Niclass ...

Millimeter Precision Laser Rangefinder Using a Low Cost Photon Counter


Single Photon Generation and Detection

Advanced Photon Counting Techniques. Vol. 6372. Niclass C, Sergio M, Charbon E. A Single Photon Avalanche Diode Array Fabricated in 0.3 μm CMOS and Based on an EventDriven Readout for TCSPC Experiments. In: Bellingham: SPIEInt. Soc.

Single Photon Generation and Detection

This chapter presents a broad review of the principle, design, fabrication, operation, and performance of single-photon avalanche diodes (SPADs), and provides a comparative basis to assess the relative merits of the wide variety of devices and techniques covered. Particular attention is paid to the design of and operation of both silicon and high-speed-gated InGaAs/InP detection systems, as well as array-based systems.

Single Photon Generation and Detection

A. Rochas, A. Pauchard, L. Monat, A. Matteo, P. Trinkler, R. Thew, and R. Ribordy, “Ultra-Compact CMOS Single Photon Detector,” in Advanced Photon Counting Techniques, edited by W. Becker, Vol. 6372, SPIE-Int. Soc.

Single Photon Generation and Detection

Single-photon generation and detection is at the forefront of modern optical physics research. This book is intended to provide a comprehensive overview of the current status of single-photon techniques and research methods in the spectral region from the visible to the infrared. The use of single photons, produced on demand with well-defined quantum properties, offers an unprecedented set of capabilities that are central to the new area of quantum information and are of revolutionary importance in areas that range from the traditional, such as high sensitivity detection for astronomy, remote sensing, and medical diagnostics, to the exotic, such as secretive surveillance and very long communication links for data transmission on interplanetary missions. The goal of this volume is to provide researchers with a comprehensive overview of the technology and techniques that are available to enable them to better design an experimental plan for its intended purpose. The book will be broken into chapters focused specifically on the development and capabilities of the available detectors and sources to allow a comparative understanding to be developed by the reader along with and idea of how the field is progressing and what can be expected in the near future. Along with this technology, we will include chapters devoted to the applications of this technology, which is in fact much of the driver for its development. This is set to become the go-to reference for this field. Covers all the basic aspects needed to perform single-photon experiments and serves as the first reference to any newcomer who would like to produce an experimental design that incorporates the latest techniques Provides a comprehensive overview of the current status of single-photon techniques and research methods in the spectral region from the visible to the infrared, thus giving broad background that should enable newcomers to the field to make rapid progress in gaining proficiency Written by leading experts in the field, among which, the leading Editor is recognized as having laid down the roadmap, thus providing the reader with an authenticated and reliable source

Optical Fiber Telecommunications VIA

K.K. Forsyth, J.C. Dries, Variations in the photoncounting performance of InGaAs/InP avalanche photodiodes, in: Proceedings ... of the SPIE – The International Society for Optical Engineering, Advanced Photon Counting Techniques, vol.

Optical Fiber Telecommunications VIA

This chapter reviews the significant advances in photodetectors that have occurred since Optical Fiber Telecommunications V. The quests for higher speed p-i-n detectors and lower noise avalanche photodiodes (APDs) with high gain-bandwidth product remain. To a great extent, high-speed structures have coalesced to evanescently coupled waveguide devices; bandwidths exceeding 140GHz have been reported. A primary APD breakthrough has been the development of Ge on Si separate-absorption-and-multiplication devices that achieve long-wavelength response with the low-noise behavior of Si. For III–V compound APDs ultra-low noise has been achieved by strategic use of complex multilayer multiplication regions that provide more deterministic impact ionization. However, much of the excitement and innovation have focused on photodiodes that can be incorporated into InP-based integrated circuits and photodetectors for Si photonics.

ETCMOS 2016 Presentation Abstracts

We are pursuing a two-pronged approach to advance the technology, (1) Identify and fix defects in the crystals, ... of implementing CZT detectors and advanced photon-counting readout electronics for multi-spectral photon-counting ...

ETCMOS 2016 Presentation Abstracts

Abstracts for presentations at the ETCMOS 2016 conference in Montreal, Canada, May 25 - 27, 2016.

Optical Fiber Telecommunications Volume VIA

[238] Chong Hu, Mingguo Liu, J.C. Campbell, Improved passive quenching with active reset circuit, in: Proceedings of the SPIE – The International Society for Optical Engineering, Advanced Photon Counting Techniques, vol.

Optical Fiber Telecommunications Volume VIA

Optical Fiber Telecommunications VI (A&B) is the sixth in a series that has chronicled the progress in the R&D of lightwave communications since the early 1970s. Written by active authorities from academia and industry, this edition brings a fresh look to many essential topics, including devices, subsystems, systems and networks. A central theme is the enabling of high-bandwidth communications in a cost-effective manner for the development of customer applications. These volumes are an ideal reference for R&D engineers and managers, optical systems implementers, university researchers and students, network operators, and investors. Volume A is devoted to components and subsystems, including photonic integrated circuits, multicore and few-mode fibers, photonic crystals, silicon photonics, signal processing, and optical interconnections. All the latest technologies and techniques for developing future components and systems Edited by two winners of the highly prestigious OSA/IEEE John Tyndal award and a President of IEEE's Lasers & Electro-Optics Society (7,000 members) Written by leading experts in the field, it is the most authoritative and comprehensive reference on optical engineering the market

Advanced Time Correlated Single Photon Counting Applications

This book is an attempt to bridge the gap between the instrumental principles of multi-dimensional time-correlated single photon counting (TCSPC) and typical applications of the technique.

Advanced Time Correlated Single Photon Counting Applications

This book is an attempt to bridge the gap between the instrumental principles of multi-dimensional time-correlated single photon counting (TCSPC) and typical applications of the technique. Written by an originator of the technique and by sucessful users, it covers the basic principles of the technique, its interaction with optical imaging methods and its application to a wide range of experimental tasks in life sciences and clinical research. The book is recommended for all users of time-resolved detection techniques in biology, bio-chemistry, spectroscopy of live systems, live cell microscopy, clinical imaging, spectroscopy of single molecules, and other applications that require the detection of low-level light signals at single-photon sensitivity and picosecond time resolution.

Advanced Photon Counting Techniques VIII

These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.

Advanced Photon Counting Techniques VIII


Advanced Photon Counting Techniques X

These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.

Advanced Photon Counting Techniques X


Free Space Laser Communications

J.R. Pierce, "Optical Channels: Practical Limits with Photon Counting," IEEE Trans. Com- mun. COM-26, 1819-1821, 1978. 27. Y. Yamamoto and H.A. Haus, "Preparation, measurement and information capacity ...

Free Space Laser Communications

This is a comprehensive tutorial on the emerging technology of free-space laser communications (FSLC). The book offers an all-inclusive source of information on the basics of FSLC, and a review of state-of-the-art technologies. Coverage includes atmospheric effects for laser propagation and FSLC systems performance and design. Free-Space Laser Communications is a valuable resource for engineers, scientists and students interested in laser communication systems designed for the atmospheric optical channel.

Dual Energy CT in Cardiovascular Imaging

Photon Counting and Spectral CT In conventional CT systems, scintillation-based detectors measure the photon intensity after ... differentiate not only the incident photons but photon energy as well [9] More advancedphoton-counting” ...

Dual Energy CT in Cardiovascular Imaging

This is the first textbook in DECT focussing especially on the cardiovascular field. DECT was developed many years ago but has recently spread its clinical utility. Many new applications have been developed over the last years and the cardiovascular system has benefited from these advances. New protocols will be used in the near future which will help to optimize results obtained until now with single energy CT, such as a more precise quantification of coronary artery stenosis using either different monochromatic levels or material decomposition, reduction of beam hardening artifacts in perfusion studies and optimizing endovenous contrast, among others.​

Modern Tools for Time Resolved Luminescence Biosensing and Imaging

The measurement of shortlived fluorescence decay using the single photon counting method. Rev Sci Instrum. (1973) 44:107–14. doi: 10.1063/1.1686062 25 ... Becker W. Advanced Time-Correlated Single Photon Counting Applications. Vol. 111.

Modern Tools for Time Resolved Luminescence Biosensing and Imaging


Energy Research Abstracts

In particular the impact on single photon counting losses of a variety of possible filling modes for the Advanced Photon Source ( APS ) is examined . For bunches of equal current , a loss of 10 % occurs whenever the count rate exceeds ...

Energy Research Abstracts


Optics and Photonics

There has been a steady progression from RF to optically based sensing, which has advanced significantly since the ... Such advanced photon-counting techniques need to be expanded not only to higher count rates but to exploitation of ...

Optics and Photonics

Optics and photonics technologies are ubiquitous: they are responsible for the displays on smart phones and computing devices, optical fiber that carries the information in the internet, advanced precision manufacturing, enhanced defense capabilities, and a plethora of medical diagnostics tools. The opportunities arising from optics and photonics offer the potential for even greater societal impact in the next few decades, including solar power generation and new efficient lighting that could transform the nation's energy landscape and new optical capabilities that will be essential to support the continued exponential growth of the Internet. As described in the National Research Council report Optics and Photonics: Essential Technologies for our Nation, it is critical for the United States to take advantage of these emerging optical technologies for creating new industries and generating job growth. The report assesses the current state of optical science and engineering in the United States and abroad-including market trends, workforce needs, and the impact of photonics on the national economy. It identifies the technological opportunities that have arisen from recent advances in, and applications of, optical science and engineering. The report also calls for improved management of U.S. public and private research and development resources, emphasizing the need for public policy that encourages adoption of a portfolio approach to investing in the wide and diverse opportunities now available within photonics. Optics and Photonics: Essential Technologies for our Nation is a useful overview not only for policymakers, such as decision-makers at relevant Federal agencies on the current state of optics and photonics research and applications but also for individuals seeking a broad understanding of the fields of optics and photonics in many arenas.

Photon Counting Applications Quantum Optics and Quantum Cryptography

A. Gulinatti , P. Maccagnani , I. Rech , M. Ghioni , S Cova , “ Planar Silicon SPADs with 200 um diameter and 35 ps photon timing ” , SPIE Proc . vol . 6372 , pp . 63720R1-9 , Advanced Photon Counting Techniques , W. Becker ed .

Photon Counting Applications  Quantum Optics  and Quantum Cryptography

Proceedings of SPIE present the original research papers presented at SPIE conferences and other high-quality conferences in the broad-ranging fields of optics and photonics. These books provide prompt access to the latest innovations in research and technology in their respective fields. Proceedings of SPIE are among the most cited references in patent literature.

Imaging from Cells to Animals In Vivo

“Lifetime-Weighted FCS and 2D FLCS: Advanced Application of Time-Tagged TCSPC.” In Advanced Photon Counting, edited by Peter Kapusta , Michael Wahl , and Rainer Erdmann , 111–128. Springer Series on Fluorescence 15.

Imaging from Cells to Animals In Vivo

This book offers an overview of imaging techniques used to investigate cells and tissue in their native environment. It covers the range of imaging approaches used, as well as the application of those techniques to the study of biological processes in cells and whole tissues within living organisms.