Advances in Bioactivation Research

This volume provides researchers with recent information on bioactivation reactions of drugs and toxicants.

Advances in Bioactivation Research

This volume provides researchers with recent information on bioactivation reactions of drugs and toxicants. It also provides examples of how molecular and genomic biology, proteomics, mass spectrometry, and computational modeling are used in bioactivation research. In other sections, focus is on recent applications of bioactivation research in pharmacology, toxicology, and environmental health sciences, where contributors demonstrate the integration of bioactivation research.

Triazine Anticonvulsants Advances in Research and Application 2011 Edition

Research. findings. from. Pfizer. Inc. update. understanding. of. life. sciences. Scientists discuss in 'Bioactivation of lamotrigine in vivo in rat and in vitro in human liver microsomes, hepatocytes, and epidermal keratinocytes: ...

Triazine Anticonvulsants  Advances in Research and Application  2011 Edition

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Thiophenes Advances in Research and Application 2011 Edition

A report, 'Investigation of bioactivation of ticlopidine using linear ion trap/orbitrap mass spectrometry and an improved mass defect filtering technique,' is newly published data in Chemical Research In Toxicology.

Thiophenes  Advances in Research and Application  2011 Edition

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Hemeproteins Advances in Research and Application 2012 Edition

Together, these in vitro data suggest that covalent binding and glutathione conjugation proceed via bioactivation to a chemically reactive intermediate. The cytochrome (CYP) P450 enzymes responsible for this bioactivation were ...

Hemeproteins   Advances in Research and Application  2012 Edition

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Sulfur Compounds Advances in Research and Application 2012 Edition

(2011 SEP 12) Bristol-Myers Squibb, Princeton: Bioactivation of substituted thiophenes including a-chlorothiophene-containing compounds in human liver microsomes Researchers detail in “Bioactivation of substituted thiophenes including ...

Sulfur Compounds   Advances in Research and Application  2012 Edition

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Antianginal Agents Advances in Research and Application 2012 Edition

A report, “Vascular bioactivation of nitroglycerin is catalyzed by cytosolic aldehyde dehydrogenase-Z,” is newly published data in Circulation Research. “According to general view, aldehyde dehydrogenase-2 (ALDH2) catalyzes the ...

Antianginal Agents   Advances in Research and Application  2012 Edition

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Mycotoxins Advances in Research and Application 2011 Edition

A study was conducted to determine the cytochrome ( CYP ) P450 enzymes responsible for the bioactivation of aflatoxin B1 ( AFB1 ) into its epoxide form ( AFBO ) in duck liver microsomes . Six male and six female 6 - week - old Pekin ...

Mycotoxins  Advances in Research and Application  2011 Edition

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Antivirals Advances in Research and Application 2012 Edition

5) University of Paris: Brief historical overview and recent progress on cytochromes P450 - adaptation of aerobic organisms to their chemical environment and new mechanisms of prodrug bioactivation Current study results from the report, ...

Antivirals   Advances in Research and Application  2012 Edition

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Carboxylic Acids Advances in Research and Application 2012 Edition

New research, “Putting bioactivation reactions to work: Targeting antioxidants to mitochondria,” is the subject of a report. According to the authors of a study from Rochester, New York, “The goal of this research was to test the ...

Carboxylic Acids   Advances in Research and Application  2012 Edition

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Protease Inhibitors Advances in Research and Application 2012 Edition

In the current study, we found that RTV also inhibits LPV bioactivation. LPV bioactivation was investigated in human liver microsomes and cDNAexpressed human cytochromes P450. Twelve GSH-trapped reactive metabolites of LPV were ...

Protease Inhibitors   Advances in Research and Application  2012 Edition

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Hemeproteins Advances in Research and Application 2013 Edition

For more information on this research see: Mechanistic stoichiometry of proton translocation by cytochrome cbb3. ... bioactivation. of. clozapine. By a News Reporter-Staff News Editor at Life Science Weekly — A new study on Drug ...

Hemeproteins   Advances in Research and Application  2013 Edition

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Phagocytes Advances in Research and Application 2012 Edition

Bioactivation. “Nimesulide, a widely used nonsteroidal anti-inflammatory drug (NSAID), has been associated with rare idiosyncratic hepatotoxicity. The chemical mechanisms underlying the liver injury remain unknown,” scientists in the ...

Phagocytes   Advances in Research and Application  2012 Edition

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Subcellular Fractions Advances in Research and Application 2012 Edition

F. Hoffmann-La Roche, Nutley: Bioactivation of glafenine by human liver microsomes and peroxidases: identification of electrophilic iminoquinone species and GSH conjugates Researchers detail in “Bioactivation of glafenine by human liver ...

Subcellular Fractions   Advances in Research and Application  2012 Edition

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Quaternary Ammonium Compounds Advances in Research and Application 2013 Edition

Prior studies suggested the involvement of cytochrome P450 (P450) 1A1 and 2W1-mediated bioactivation in the antitumor activities and P450 251-mediated deactivation of SF 203 and GW 610.” The news correspondents obtained a quote from the ...

Quaternary Ammonium Compounds   Advances in Research and Application  2013 Edition

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Acetanilides Advances in Research and Application 2013 Edition

Bioactivation Potential and Metabolism Profile of Zebrafish versus Human By a News Reporter-Staff News Editor at Life Science Weekly — New research on Metabolism is the subject of a report. According to news reporting out of Singapore, ...

Acetanilides   Advances in Research and Application  2013 Edition

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Antiplatelet Agents Advances in Research and Application 2013 Edition

For more information on this research see: Aspirin and Other COX-1 inhibitors. ... London: Clarifying the importance of CYP2C19 and PON1 in the mechanism of clopidogrel bioactivation and in vivo antiplatelet response By a News ...

Antiplatelet Agents   Advances in Research and Application  2013 Edition

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Thiazoles Advances in Research and Application 2013 Edition

Pennington: Bioactivation. of. 2-(alkylthio)-1,3,4-thiadiazoles. and. 2-(alkylthio)-1,3-benzothiazoles. By a News Reporter-Staff News Editor at Chemicals & Chemistry – Investigators publish new report on General Chemical Research.

Thiazoles   Advances in Research and Application  2013 Edition

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Antibiotics Antineoplastics Advances in Research and Application 2012 Edition

Previous research has identified most of the components that comprise the doxorubicin bioactivation network; however, adaptation of the network to changes in doxorubicin treatment or to patient-specific changes in network components is ...

Antibiotics   Antineoplastics   Advances in Research and Application  2012 Edition

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Quinones Advances in Research and Application 2013 Edition

The news correspondents obtained a quote from the research from the Chinese Academy of Sciences, “This study aimed at characterizing the bioactivation pathway(s) 0f 5-CQA and the metabolic enzyme(s) involved. After incubating 5-CQA with ...

Quinones   Advances in Research and Application  2013 Edition

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Peptide Receptors Advances in Research and Application 2011 Edition

Translational Research Institute, Jupiter: Cytochrome P450-mediated bioactivation of the epidermal growth factor receptor inhibitor erlotinib to a reactive electrophile A report, 'Cytochrome P450-mediated bioactivation of the epidermal ...

Peptide Receptors  Advances in Research and Application  2011 Edition

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