Basophil and Mast Cell Degranulation and Recovery

In this book, I review much of the structural information regarding basophils and mast cells of multiple species.

Basophil and Mast Cell Degranulation and Recovery

Basophils and mast cells are similar but unique secretory cells with a well-documented role in immediate-hypersensitivity reactions. The presence of these cells in various cell mediated hypersensitivity reactions, in tissues of multiple diseases, and as a component of the host reaction to injury and repair in numerous circumstances is well known. Release of stored and newly generated mediators of inflammation from basophils and mast cells contributes to the cascade of pathogenetic events in circumstances under which these release reactions occur. Despite insights acquired through studies of these pathologic events, the role of basophils and mast cells and their secretory products in health is not known. In this book, I review much of the structural information regarding basophils and mast cells of multiple species. Ultrastructural studies of rat mast cells historically precede and quantitatively exceed similar studies of basophils and mast cells of other species. Therefore, I first review these background studies as an entity. Then I discuss the contents of two prominent organelles-granules and lipid bodies-in basophils and mast cells of several species. The ultrastructural morphology of basophils and mast cells in three species is presented in detail to establish appropriate guidelines for their recognition and to provide general rules for analysis which are appropriate for the identification of these cells in other species as well.

Human Mast Cells

This book looks in detail at human mast cells.

Human Mast Cells

This book looks in detail at human mast cells. It includes a review of previous and current ultrastructural studies, whereby the latter are illustrated with numerous high-quality electron micrographs obtained from a large number of structural and functional experiments using highly purified isolated human lung mast cells. Specifically, the book provides criteria for the identification of human mast cells, discusses the unique role in mast cell function of granules and lipid bodies, describes the ultrastructural anatomy of two release reactions - i.e., anaphylactic degranulation and piecemeal degranulation - and defines the recovery, cyclical and maturational properties of human mast cells. All of these new morphological-biochemical and functional studies are correlated with the author's wide experience in the visual properties of human mast cells as seen in biopsy material obtained from a diagnostic ultrastructural pathology service.

Mast Cells and Basophils

C. V. Mosby, St. Louis, 1988. Dvorak, A. M., ed. Basophil and Mast Cell Degranulation and Recovery. Blood Cell Biochemistry, Vol. 4 (Harris, J. R., ed.).

Mast Cells and Basophils

Mast Cells and Basophils will be essential reading for immunologists, biochemists and medical researchers. Detailed chapters cover all aspects of mast cell and basophil research, from cell development, proteases, histamine, cysteinyl leukotrienes, physiology and pathology to the role of these cells in health and disease. Chapters also discuss the clinical implications of histamine receptor antagonists.

The Mast Cell in Health and Disease

In Basophil and Mast Cell Degranulation and Recovery . Vol . 4 : Blood Cell Biochemistry series . Series Editor J. R. Harris , Vol Editor A. M. Dvorak .

The Mast Cell in Health and Disease

Offers coverage of practical and theoretical implications of current research into mast cell biology, emphasizing the role of the mast cell in human diseases. The text covers all aspects of the mast cell from growth and differentiation to its function in such conditions as asthma and skin disease.

International Review of Cytology

Basophils and mast cells: Piecemeal degranulation in situ and ex vivo: A ... Ultrastructural analysis of human basophil and mast cell recovery after ...

International Review of Cytology

International Review of Cytology presents current advances and comprehensive reviews in cell biology--both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Gene Expression during Amphibian Limb Regeneration The Extracellular Matrix Biochemistry of Volvox The Cell Biology of Basophils Membrane Receptors for Endocytosis in the Renal Proximal Tubule

Signal Transduction in Mast Cells and Basophils

Basophil and mast cell degranulation and recovery. In: Harris RJ, ed. Blood Cell Biochemistry. New York: Plenum Press, 1991; 4:1. Irani AA, Schechter NM, ...

Signal Transduction in Mast Cells and Basophils

Focussing on the molecular mechanisms that govern mast cell and basophil cell biology and function, this book also provides a comprehensive summary of the field of signal transduction, giving insights into areas that have therapeutic potential. It gives detailed insights into mast cell and basophil growth and development, their activation by allergens, including details of receptor activation and downstream events, and the regulators of morphology and degranulation. The metabolic pathways involved in prostaglandin and leukotriene production are discussed as is the role of transcription factors in mast cell growth and cytokine production. Written by leaders in the field, this volume will provide readers with an up-to-date account of a topic whose rapid progress makes conventional information gathering difficult.

Mast Cells and Tumours

Acta Anat (Basel) 105:505–513 Dvorak AM (1991) Basophil and mast cell degranulation and recovery. In: Harris JR (ed) Blood cell Biochemistry, vol 4.

Mast Cells and Tumours

Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found in tissues from multiple disease sites, and as a component of the host reaction to bacteria, parasite, and even virus infections. They have also been shown to participate to angiogenic and tissue repair processes after injury. The importance of a possible functional link between chronic inflammation and cancer has long been recognized. As most tumours contain inflammatory cell infiltrates, which often include plentiful mast cells, the question as to the possible contribution of mast cells to tumour development has progressively been emerged. In this book, the general biology of these cells, their development, anatomical distribution and phenotype as well as their secretory products will first be discussed. The biology of tumour cells, their structural and molecular characteristics, the specificity of the tumour microenvironment and the development of a vascular network in the tumour context will be analyzed. The involvement of mast cells in tumour biology and tumour fate will then be considered, with particular emphasis on the capacity of these cells to stimulate tumour growth by promoting angiogenesis and lymphangiogenesis. The last chapter suggest that mast cells may serve as a novel therapeutic target for cancer treatment.

Ultrastructure of Mast Cells and Basophils

... 96 inflammation role 95 overview of imaging techniques 99 piecemeal degranulation in human mast cells 148, 149 recovering human basophil expression 217, ...

Ultrastructure of Mast Cells and Basophils

In this book, the author reviews the ultrastructural studies of basophils and mast cells performed since the publication of an earlier monograph in 1991. These studies include the use of ultrastructural rules that allow identification of basophils and mast cells in new circumstances. Including more than 180 excellent micrographs, this book will be of interest to basic scientists in immunology, cell biology, secretion and angiogenesis research, and histochemistry. As mast cells and basophils play a crucial role in various diseases, it will be essential reading for allergists, immunologists, dermatologists, hematologists, gastroenterologists, rheumatologists, neurologists, pathologists, pulmonologists, and cardiologists.

Wintrobe s Clinical Hematology

This recovery occurs within 1 to 2 days , but may also take longer . Whether death by necrosis or apoptosis is a feature of mast cell or basophil activation ...

Wintrobe s Clinical Hematology

Now available in a thoroughly revised Twelfth Edition, Wintrobe's Clinical Hematology continues to be an industry leader with its ability to correlate basic science with the clinical practice of hematology. With the first edition of Wintrobe's Clinical Hematology published in 1942 clearly establishing hematology as a distinct subspecialty of Internal Medicine, the latest edition continues the influence of the Wintrobe name and helps to set this book apart from the competition.With its strong focus on the clinical aspects of hematology, the book has generated a strong following among internists and general practitioners who want a single resource to consult for their patients who present any blood related disorder. The Twelfth Edition is in full color for the first time, boasts a new editorial team, and includes expanded coverage of new medications and four new chapters on Newborn Anemias, Pathology of LHC, Spleen Tumors, and Myeloproliferative Disorders and Mast Cell Disease. A companion Website will offer the fully searchable text and an image bank.

International Review of Cell and Molecular Biology

The multitasking mast cell: Positive and negative roles in the progression of autoimmunity. ... Basophil and mast cell degranulation and recovery.

International Review of Cell and Molecular Biology

International Review of Cell & Molecular Biology presents current advances and comprehensive reviews in cell biology—both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. * Authored by some of the foremost scientists in the field * Provides up-to-date information and directions for future research * Valuable reference material for advanced undergraduates, graduate students and professional scientists

Immunopharmacology Reviews

Dvorak, A. M., 1991, Basophil and Mast Cell Degranulation and Recovery, ... L. M., 1980, Antigen-induced IgEmediated degranulation of human basophils, Lab.

Immunopharmacology Reviews

'A thoroughly enjoyable and very useful work. As the editors say in their preface, 'we have intended these reviews to be the best by the best'-they make this point very convincingly.' -ASM News, from a review of Volume 1 This series continues to present the most current findings in the field of immune manipulation. Here, twelve chapters provide detailed coverage of cancer, microbial, and allergy immunopharmacology as well as autoimmunity and neuroimmunomodulation.

Allergy and Allergic Diseases

Dvorak AM (1991) Degranulation of basophils and mast cells. In: Dvorak AM, ed. ... 4, Basophil and Mast Cell Degranulation and Recovery. Plenum, London, pp.

Allergy and Allergic Diseases

Allergy and Allergic Diseases has been organized to provide an up-to-date, clinically relevant compilation of one of the most exciting areas of investigation in medicine today-allergic disease, especially as it pertains to the skin, airways, and bowel. With the dramatic rise in the incidence of various allergic disorders worldwide, and the coming of age of the discipline of Clinical Immunology and Allergy, the interface between basic and clinical science in this arena demands highlighting in this comprehensive new syn thesis.1t is with the hope of filling this evident need that Allergy and Allergic Diseases: The New Mechanisms and Therapeutics has been put together. The book's content is divided into both basic and clinical sections, with emphasis on various components of the immune and inflammatory response as they relate to the development of allergic disease. Topics span the range from molecular biology to clinical symptomatology, with an effort to make this of interest to as broad a constituency as possible. This book will therefore be of substantial interest to specialists in Clinical Immunology and Allergy, scientists studying the cellular and molecular biology of in flammation and immunity, as well as internists, teachers, developers of medical school curricula, and members of industry focused on drug discovery and therapeutics. Indeed, a separate section has been added to deal with some specific issues in this latter field.

Food Hypersensitivity and Adverse Reactions

Schwartz L, Huff T. Biology of mast cells and basophils. In: Middleton E, Reed CE, ... Basophil and mast cell degranulation and recovery. In: Harris JR, ed.

Food Hypersensitivity and Adverse Reactions

Presents classic and recent findings on immunological dysfunctions caused by food allergies-coordinating the most advanced clinical techniques and assessment methods with practical insights for treatment and patient care.

Diagnostic Ultrastructural Pathology

79-81,93,94 bers of interstitial mast cells.5,55,56 The increased numbers of ... Basophil and Mast Cell Degranulation and Recovery , Harris , J. R. , Series ...

Diagnostic Ultrastructural Pathology

Diagnostic Ultrastructural Pathology, Volumes II and III, presents individual problem-based cases in a well-illustrated format, using numerous electron micrographs to convey appropriate and necessary visual information for the diagnosis of human disease. The format facilitates the teaching of the case approach for diagnostic ultrastructural pathology using clinical-ultrastructural-pathologic correlation. These guides illustrate key reasoning processes that physicians use to resolve individual clinical problems through the use of electron microscopy. The material is useful to a wide variety of physicians and students of medicine, structure, and disease at various levels of training, as well as in the training of and operational use by technical support staff. The two volumes include a total of 50 cases and a procedural guide for the ultrastructural pathology laboratory. The cases were selected using four principal criteria: (1) classic cases, which are diagnosed readily by light microscopy to facilitate the electron microscopic diagnosis of less classic cases; (2) diagnostic cases, for which ultrastructural analysis is essential for diagnosis; (3) supportive cases, where either the light or the electron microscopic diagnosis is supportive, and thus confirmatory, of the other; and (4) new facts cases, which establish new knowledge regarding the pathogenesis of disease using electron microscopy as the investigative modality. The 50 cases are grouped anatomically in four major categories. Volume II contains the sections on the respiratory and nervous systems, and Volume III presents the cases dealing with the endocrine and hematopoietic systems. Each section is preceded by introductory remarks. Each case cites relevant, classic, anatomic pathology papers and related research papers. These volumes also include multiple functional indices, providing ready access to the material from several starting points. There are separate indices for presenting symptoms, differential diagnostic groups, ultrastructural pathology criteria, and final diagnostic categories. As a valuable resource and guide, Diagnostic Ultrastructural Pathology, Volumes II and III, is an excellent, high-quality addition to the field of diagnostic pathology.

Eosinophils in Allergy and Inflammation

4:Basophil and Mast Cell Degranulation and Recovery. London: Plenum Press, 1991:27-65. 43. Dvorak AM, Dvorak HF, Peters SP, Schulman ES, MacGlashan DW Jr, ...

Eosinophils in Allergy and Inflammation

This work presents the proceedings of a conference held at Adare Manor, County Limerick, Ireland. It provides an updated, in-depth review of the biological role of eosinophils in allergic diseases, summarizing basic knowledge of these unique cationic proteins. The book features an annotated discussion of the conference's post-presentation question-and-answer session.

Immunopharmacology of Mast Cells and Basophils

Recovery of human lung mast cells from anaphylactic degranulation utilizes a mixture of conservation and synthetic mechanisms . In “ Mast Cell and Basophil Differentiation and Function in Health and Disease ” ( eds S.J. Galli and K.F. ...

Immunopharmacology of Mast Cells and Basophils

There has been a steady and continued research effort directed to understanding both the function and the role of mast cells and basophils ever since these cells were first described at the end of the nineteenth century. One of the most significant advances has perhaps been the appreciation of the fact that mast cells do not represent a single homogenous population of cells: they display heterogeneity at the morphological, biochemical and functional levels. The one characteristic that unites all types of mast cells and basophils appears to be the possession of the high affinity membrane receptor for immunoglobulin E, through which the cells may be stimulated. This volume begins with a review of the origin and development of mast cells and basophils. It continues by reviewing our knowledge of the stimuli to mast cells and basophils and the biochemical mechanisms which link the signal generated by stimulus to the response machinery of the cell. Further chapters deal with the drug control of mast cell and basophil responses, the heterogeneity of the cells' functions and the mediators' release by the cells, along with the morphological aspects of the cells' function. This book is completed by a selection of examples which examine the role of the mast cells or basophils in lung, skin and gastrointestinal tract. However, the role of the mast cell with regard to normal physiology, remains an open question. This book aims to provide an up-to-date account of mast cell and basophil biology, together with an insight into the functional relevance of these cells in some tissue types.

Trends in Stem Cell Proliferation and Cancer Research

In: Dvorak AM (ed) Blood cell biochemistry. Basophil and mast cell degranulation and recovery, vol 4. Plenum, New York Dvorak AM, Morgan E, Schleimer RP, ...

Trends in Stem Cell Proliferation and Cancer Research

The book will discuss the molecular mechanisms of cancer diseases, stem cell proliferation and transformation into cancer cells beyond the physiological processes that occur in normal stem cell biology. Some of the key oncogenic events in cancer and their signaling pathways that regulate cell division cycle progression will be described considering prospects for using such knowledge in advanced cancer therapy. Each chapter shall provide an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance

Handbook of Research on Systems Biology Applications in Medicine

The Journal of Cell Biology, 130, 897-907. Dvorak, A. M. (1991). Basophil and mast cell degranulation and recovery. New York: Plenum Press.

Handbook of Research on Systems Biology Applications in Medicine

"This book highlights the use of systems approaches including genomic, cellular, proteomic, metabolomic, bioinformatics, molecular, and biochemical, to address fundamental questions in complex diseases like cancer diabetes but also in ageing"--Provided by publisher.

Current Catalog

Dvorak , Ann M. Basophil and mast cell degranulation and recovery / Ann M. Dvorak . New York : Plenum Press , c1991 . viii , 415 p . : ill .

Current Catalog

First multi-year cumulation covers six years: 1965-70.

Mast Cells Mediators and Disease

Immunoglobulin E-mediated degranulation of isolated human lung mast cells. ... ability to identify mast cells and basophils in man, guinea pig and mouse.

Mast Cells  Mediators and Disease

In 1879 Paul Ehrlich first described the mast cell as a tissue fixed cell contain ing many granules which, when stained with basic dyes, such as toluidine blue, changed the colour spectrum of the dye in a process called meta chromasia. Since this early description, pathologists, physicians and pharmacologists have been fascinated by this cell on account of its central involvement in human allergic diseases. Approximately four decades after Ehrlich's first description of the mast cell, Prausnitz and Kiistner reported their pioneer experiment, demonstrating that the immediate skin wheal response to allergen could be passively transferred with serum. They named the antigen-specific serum factor reagin. A further four and one half decades had to pass before the connection between the mast cell and reagin could be made with the identification of reagin as an immunoglobulin E by Johansson and Ishizaka and its unique property to bind with high affinity to specific receptors on mast cells and basophils. Meanwhile in the 1920s Coca published a series of papers in which he described the clinical features of acute allergic responses and first used the term atopy. This, together with the fundamental pharmacological studies of Sir Henry Dale in identifying histamine as one mediator of the acute ana phylactic reaction, provided the second approach which eventually linked the mast cell to allergic tissue reactions. Indeed, it was Best, working in Dale's group who first showed that histamine was a chemical stored in mast cells.