Biosimulation in Biomedical Research Health Care and Drug Development

Chapter 1 Modeling in Biomedical Research and Health Care Steen G. Dawids, Jakob L. Laugesen, and Erik Mosekilde Modeling ... 1.1 Efficiency, Safety and Money, and the Challenge to Science The fantastic development that the biomedical ...

Biosimulation in Biomedical Research  Health Care and Drug Development

Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment. This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic.

Biosimulation in Biomedical Research Health Care and Drug Development

Furthermore this volume provides a discussion of the use of models in the pharmaceutical industry, and presents the view of the regulatory agencies on the topic.

Biosimulation in Biomedical Research  Health Care and Drug Development

Biosimulation is an approach to biomedical research and the treatment of patients in which computer modeling goes hand in hand with experimental and clinical work. Constructed models are used to interpret experimental results and to accumulate information from experiment to experiment. This book explains the concepts used in the modeling of biological phenomena and goes on to present a series of well-documented models of the regulation of various genetic, cellular and physiological processes. The way how the use of computer models allows optimization of cancer treatment for individual patients is discussed and models of interacting nerve cells that can be used to design new treatments for patients with Parkinson's disease are explained. Furthermore this volume provides an overview on the use of models in industry, and presents the view of regulatory agencies on the topic.

Biosimulation in Drug Development

In 2000 the Declaration of Helsinki on biomedical research was amended and now takes into account the Three Rs. It now opens ... in Drug Development Biosimulation is a potential new tool in drug development and health care that, ...

Biosimulation in Drug Development

This first comprehensive survey to cover all pharmaceutically relevant topics provides a comprehensive introduction to this novel and revolutionary tool, presenting both concepts and application examples of biosimulated cells, organs and organisms. Following an introduction to the role of biosimulation in drug development, the authors go on to discuss the simulation of cells and tissues, as well as simulating drug action and effect. A further section is devoted to simulating networks and populations, and the whole is rounded off by a look at the potential for biosimulation in industrial drug development and for regulatory decisions. Part of the authors are members of the BioSim Network of Excellence that encompasses more than 40 academic institutions, pharmaceutical companies and regulatory authorities dealing with drug development; other contributors come from industry, resulting in a cross-disciplinary expert reference.

Advances in Cognitive Neurodynamics V

Biosimulation in Biomedical Research, Health Care and Drug Development, pp. 93–126. Springer, Wien (2011) 3. Braun, H.A., Postnova, S., Wollweber, B.T., Schneider, H., Belke, M., Voigt, K., Hemmeter, U., Huber, M.T.: Biological rhythms ...

Advances in Cognitive Neurodynamics  V

This proceedings contains articles submitted to the fifth International Conference on Cognitive Neurodynamics (ICCN2015). In ICCN2015, twelve invited plenary lectures were presented by the leading scientists in their respective research fields. More than 15 mini-symposiums are organized by specialists with topics covering: motor control and learning, dynamic coding in distributed neural circuits, dynamics of firing patterns and synchronization in neuronal systems, information and signal processing techniques in neurotechnology, neural oscillations and synaptic plasticity in the hippocampus, new perspective on model-based vs. model-free brain process, neural mechanisms of internal switching, neuroinformation computation, neural model and dynamics, imaging human cognitive networks, neuroinformatics, neuroergonomics & neuroengineering, dynamic brain for communication, visual information processing and functional imaging and neural mechanisms of language processing. All articles are peer-reviewed. The ICCN is a series conference held every two years since 2007.

Textbook of Cortical Brain Stimulation

Biosimulation in Biomedical Research, Health Care and Drug Development. Wien: Springer-Verlag, 2012, p179--199 Brittain JS, Probert-Smith P, Aziz TZ, Brown P. Tremor suppression by rhythmic transcranial current stimulation.

Textbook of Cortical Brain Stimulation

Developed over the past 25 years, Cortical Brain Stimulation has emerged as a brand new, cutting-edge option for the treatment of intractable neurological and psychiatric disorders. Devoid of the mortality and disabling morbidity that may accompany deep brain stimulation, stimulating the cortex with a minimally invasive surgical approach had initially proved its worth for the treatment of Central and other Neuropathic Pain Syndromes and later for Parkinson Disease, Dystonia, Stroke and Coma rehabilitation, Epilepsy, Depression and Tinnitus. Written by many of the pioneers in the field, this authoritative treatise is a comprehensive presentation - from surgical details, to clinical results and mechanisms of action. It also provides the busy clinician with comparisons with non-invasive cortical stimulation techniques, such as TMS and tDCS. No other book deals with this form of brain stimulation. The clinician will harness the power of this formidable new therapeutic option, which is being further refined with the advent of closed-loop stimulation. Dr Canavero deciphered the genesis of the central pain syndromes, introduced extradural cortical stimulation for Parkinson Disease and the vegetative state and co-introduced extradural cortical stimulation for stroke rehabilitation. He made worldwide news in 2008 for partially restoring consciousness in two vegetative patients, in 2013 for proposing the HEAVEN/GEMINI protocol for human head transplantation and in 2014 for pushing brain stimulation in the setting of criminal psychopathy. His books include: Central Pain Syndrome, Cambridge Univ. Press, 2011 (2nd ed.), Textbook of therapeutic cortical stimulation, Nova Sci, 2009 and two books in Italian on human sexual behavior.

Personalized Predictive Modeling in Type 1 Diabetes

Biosimulation in biomedical research, health care and drug development. Vienna: Springer Vienna; 2012. p. 329À59. Kobayashi T, et al. The pharmacokinetics of insulin after continuous subcutaneous infusion or bolus subcutaneous injection ...

Personalized Predictive Modeling in Type 1 Diabetes

Personalized Predictive Modeling in Diabetes features state-of-the-art methodologies and algorithmic approaches which have been applied to predictive modeling of glucose concentration, ranging from simple autoregressive models of the CGM time series to multivariate nonlinear regression techniques of machine learning. Developments in the field have been analyzed with respect to: (i) feature set (univariate or multivariate), (ii) regression technique (linear or non-linear), (iii) learning mechanism (batch or sequential), (iv) development and testing procedure and (v) scaling properties. In addition, simulation models of meal-derived glucose absorption and insulin dynamics and kinetics are covered, as an integral part of glucose predictive models. This book will help engineers and clinicians to: select a regression technique which can capture both linear and non-linear dynamics in glucose metabolism in diabetes, and which exhibits good generalization performance under stationary and non-stationary conditions; ensure the scalability of the optimization algorithm (learning mechanism) with respect to the size of the dataset, provided that multiple days of patient monitoring are needed to obtain a reliable predictive model; select a features set which efficiently represents both spatial and temporal dependencies between the input variables and the glucose concentration; select simulation models of subcutaneous insulin absorption and meal absorption; identify an appropriate validation procedure, and identify realistic performance measures. Describes fundamentals of modeling techniques as applied to glucose control Covers model selection process and model validation Offers computer code on a companion website to show implementation of models and algorithms Features the latest developments in the field of diabetes predictive modeling

Functional Brain Mapping Methods and Aims

In: Biosimulation in biomedical research, health care and drug development. Springer, pp 133–151 73. ... The complementary roles of inductive and hypothesis-driven science in the post-genomic era. BioEssays 26:99–105 75.

Functional Brain Mapping  Methods and Aims

This book provides an essential overview of the broad range of functional brain imaging techniques, as well as neuroscientific methods suitable for various scientific tasks in fundamental and clinical neuroscience. It also shares information on novel methods in computational neuroscience, mathematical algorithms, image processing, and applications to neuroscience. The mammalian brain is a huge and complex network that consists of billions of neural and glial cells. Decoding how information is represented and processed by this neural network requires the ability to monitor the dynamics of large numbers of neurons at high temporal and spatial resolution over a large part of the brain. Functional brain optical imaging has seen more than thirty years of intensive development. Current light-using methods provide good sensitivity to functional changes through intrinsic contrast and are rapidly exploiting the growing availability of exogenous fluorescence probes. In addition, various types of functional brain optical imaging are now being used to reveal the brain’s microanatomy and physiology.

Astrocytes Ca2 Signaling in the Modulation of Neural Networks Excitability and Synaptic Transmissions

... Biosimulation in Biomedical Research, Health Care and Drug Development, eds E. Mosekilde, O. Sosnovtseva, and A. RostamiHodjegan (Vienna: Springer), 133–151. doi: 10.1007/978-3-7091-0418-7_6 Postnov, D. E., Koreshkov, R. N., Brazhe, ...

Astrocytes Ca2  Signaling in the Modulation of Neural Networks Excitability and Synaptic Transmissions


Textbook of Personalized Medicine

The International Society of Intelligent Biological Medicine (http://www.isibm.org) touches future bioinformatics and personalized medicine throughout current efforts in promoting the research, education and awareness of the upcoming ...

Textbook of Personalized Medicine

Advances in the technology used in personalized medicine and increased applications for clinical use have created a need for this expansion and revision of Kewal K. Jain’s Textbook of Personalized Medicine. As the first definitive work on this topic, this book reviews the fundamentals and development of personalized medicine and subsequent adoptions of the concepts by the biopharmaceutical industry and the medical profession. It also discusses examples of applications in key therapeutic areas, as well as ethical and regulatory issues, providing a concise and comprehensive source of reference for those involved in healthcare management, planning and politics. Algorithms are included as a guide to those involved in the management of important diseases where decision-making is involved due to the multiple choices available. Textbook of Personalized Medicine, Second Edition will serve as a convenient source of information for physicians, scientists, decision makers in the biopharmaceutical and healthcare industries and interested members of the public.

Index Medicus

INSURANCE , PHARMACEUTICAL SERVICES Biomedical informatics : the future for drug development . Liebman ( Kaposi's sarcoma of the ... One specialized need : " understanding the role of veterinary medicine in public health " .

Index Medicus


Advances in Personalized Nanotherapeutics

... the healthcare to better disease diagnostics and management. These developments bring a sea of data for the physician and biological researchers to analyze and overcome the challenges of poor penetration of the available drugs into ...

Advances in Personalized Nanotherapeutics

Personalized health care to manage diseases and optimized treatment is crucial for everyone to maintain health quality. Significant efforts have been made to design and develop novel nano-enabling therapeutic strategies to cure and monitor diseases for personalized health care. As state-of-the-art, various strategies have been reported to develop personalized nanomedicine to combat against target diseases with no side effects. In this book proposal, we are trying to describe fundamentals of personalized nanomedicine, novel nanomaterials for drug delivery, role of nanotechnology for efficient therapeutics approach, nano-pharmacology, targeted CNS drug delivery, stimuli responsive drug release and nanotechnology for diseases management. This book would serve as a platform for new scholars to understand state-of-the-art of nanotechnology for therapeutics and designing their future research to develop effective personalized nanomedicine against targeted diseases. As of now, various studies have been reported to design and develop nanomedicines of higher efficacy but unfortunately, such products are up to laboratory research only and need to be well-tested using pre-clinical or human models. Our book would be a call for experts to explore multidisciplinary research for developing novel and efficient approaches to explore smart efficient nanocarriers for site-specific on-demand controlled drug delivery to combat against targeted diseases to personalized health care.

Biosimulation

Biosimulation This practical guide to biosimulation provides the hands-on experience needed to devise, design, and analyze simulations of biophysical processes for applications in biological and biomedical sciences.

Biosimulation

A hands-on guide to devising, designing and analyzing simulations of biophysical processes for applications in biological and biomedical sciences. Practical examples are given throughout, representing real-world case studies of key application areas, and all data and complete codes for simulation and data analysis are provided online.

Scientific and Technical Aerospace Reports

3 including research on medicine , chemistry , oceanography , and related sciences [ AD - 759356 ] 08 p0997 N74-17694 ... medicine aerospace medicine meeting on nystagmus [ AGARD - CP - 128 ) 12 p1382 N74-20732 Aeromedical research and ...

Scientific and Technical Aerospace Reports


Research Anthology on Diagnosing and Treating Neurocognitive Disorders

Precision Medicine Using Individualized Biosimulations of Drug Dosing : Alzheimer's Disease. In Proceedings of the IEEE Health Innovations and Point-of-Care Technologies Conference (pp. 292–295). 10.1109/HIC.2014.7038932 Sahin-Toth, M., ...

Research Anthology on Diagnosing and Treating Neurocognitive Disorders

Cognitive impairment, through Alzheimer’s disease or other related forms of dementia, is a serious concern for afflicted individuals and their caregivers. Understanding patients’ mental states and combatting social stigmas are important considerations in caring for cognitively impaired individuals. Technology is playing an increasing role in the lives of the elderly. One of the most prevalent developments for the aging population is the use of technological innovations for intervention and treatment of individuals with mental impairments. Research Anthology on Diagnosing and Treating Neurocognitive Disorders examines the treatment, diagnosis, prevention, and therapeutic and technological interventions of neurodegenerative disorders. It also describes programs and strategies that professional and family caregivers can implement to engage and improve the quality of life of persons suffering from cognitive impairment. Highlighting a range of topics such as dementia, subjective wellbeing, and cognitive decline, this publication is an ideal reference source for speech pathologists, social workers, occupational therapists, psychologists, psychiatrists, neurologists, pediatricians, researchers, clinicians, and academicians seeking coverage on neurocognitive disorder identification and strategies for clinician support and therapies.

Sleep Medicine

A Comprehensive Guide to Its Development, Clinical Milestones, and Advances in Treatment Sudhansu Chokroverty, ... TN, USA Mark R. Pressman Sleep Medicine Services, Lankenau Medical Center/Lankenau Institute For Medical Research, ...

Sleep Medicine

This comprehensive volume provides a balanced and easily readable account of the rise of modern sleep medicine, its history and developmental milestones. Authored by an international group of experts, the remarkable progress and fascinating evolution from rudimentary concepts of the ancient prehistoric and early classical periods to our contemporary knowledge are covered in detail. These examples and their relationship to modern therapies offer neurologists, psychiatrists, respiratory specialists, clinicians, researchers and those interested in sleep medicine an important perspective to the origins of current practice.

Issues in Diabetes Endocrinology and Hepatology 2011 Edition

Medicine,. Atlanta: Diabetes. care in black and white veterans in the southeastern u.s A new study, 'Diabetes care ... but progress has been difficult because of racial/ethnic differences in insurance coverage and access to health care.

Issues in Diabetes  Endocrinology  and Hepatology  2011 Edition

Issues in Diabetes, Endocrinology, and Hepatology: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Diabetes, Endocrinology, and Hepatology. The editors have built Issues in Diabetes, Endocrinology, and Hepatology: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diabetes, Endocrinology, and Hepatology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Diabetes, Endocrinology, and Hepatology: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Encyclopedia of Medical Organizations and Agencies

Research studies are developed in connection with clinical services and with subject groups recruited for special projects . ... Also conducts drug research , studies of innovative care , and application of new technology .

Encyclopedia of Medical Organizations and Agencies


Systems Medicine

Summary Open model repositories collect, curate and then publish models and associated simulation studies, ... in the domains of Biology and Systems Medicine who are interested in reusing or publishing reproducible simulation studies.

Systems Medicine

Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

Patient Specific Modeling of the Cardiovascular System

Technology-Driven Personalized Medicine Roy C.P. Kerckhoffs. clinicians and the fact that PS models used in critical care must often rely on timetested, minimal models, it is somewhat surprising that more success stories of applied PS ...

Patient Specific Modeling of the Cardiovascular System

Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.