Cardiac Mechano Electric Coupling and Arrhythmias

Rev. ed. of: Cardiac mechano-electric feedback and arrhythmias. 2005.

Cardiac Mechano Electric Coupling and Arrhythmias

Rev. ed. of: Cardiac mechano-electric feedback and arrhythmias. 2005.

Cardiac Mechano electric Feedback and Arrhythmias

Electrical remodeling (Continued) in dilated cardiomyopathy, 233 hypertrophy, 261 reversibility of, 264 Electrical restitution, 1 14 Electrocardiography, 1 37 in commotio cordis, 137, 274, 274f in respiratory sinus arrhythmia assessment ...

Cardiac Mechano electric Feedback and Arrhythmias

Kohl (Cardio Mechano-Electric Feedback Lab, Oxford University) documents the role of mechano-electric feedback (MEF) in electrical and mechanical pathological remodeling of cardiac function. Sections cover sub-cellular mechanisms of cardiac MEF, effects of MEF on cardiac cellular electrophysiology, experimental manifestations of MEF in the heart, cardiac MEF in normal physiology, cardiac MEF as a pathogenic mechanism, MEF as a mechanism involved in therapeutic interventions, and the outlook for the future. B&w and color photos and medical images are included. Annotation: 2005 Book News, Inc., Portland, OR (booknews.com).

Emerging Technologies for Heart Diseases

Cardiac mechano-electric coupling and arrhythmias. 2nd ed. Oxford: Oxford University Press; 2011. [12] Quinn TA, Kohl P, Ravens U. Cardiac mechano-electric coupling research: fifty years of progress and scientific innovation.

Emerging Technologies for Heart Diseases

The increasing pace of advances in cardiology throughout the last few decades has fundamentally altered the natural course of heart patients. In the last few years, available therapies have been revolutionized completely by new transcatheter therapeutic approaches, novel ventricular assist devices, and new drugs. Also, molecular biology and genetics have a rapidly growing impact on cardiovascular diseases, enabling the field of regenerative medicine to become increasingly closer to routine clinical implementation. Emerging Technologies for Heart Diseases was conceived to cover the recent extensive literature on current and novel therapeutic options for cardiac patients. The first volume is dedicated to heart failure and valvular disorders, and the second covers myocardial ischemia and arrhythmias. The clinical topic is addressed in several chapters divided according to the therapeutic approach (mechanical or electrical device-based, or cell and gene-based). Each of the 46 chapters focuses on clinically available solutions, new therapies currently under evaluation in clinical trials, promising preclinical technologies, and emerging concepts and innovations that have not yet been tested in a preclinical model. Also, the book discusses future challenges and opportunities for clinical implementation. Lessons learned from abandoned experimental practices are also covered, giving the readers the widest possible perspective of current therapeutic dilemmas. Overall, this textbook was designed for physicians who want to stay up-to-date with current therapies and those of the future, for biomedical companies, and for those who wish to broaden their knowledge of new cardiovascular therapeutic options. Provides a comprehensive review of the latest therapeutic developments for heart failure, valvular disorders, myocardial ischemia and arrhythmias, and their clinical implications Written by both specialists in the field and established researchers, it delivers a review of emerging medical technologies and presents insight into their therapeutic promise Chapters are arranged according to disease pathogeneses and relevance and include coverage of the mechanical, electrophysiological, and biological approaches for the management of patients with myocardial ischemia and arrhythmias

Cardiac Electrophysiology From Cell to Bedside E Book

Dosdall DJ, Doppalapudi H, Ideker RE: Mechanical modulation of defibrillation and resuscitation efficacy. In Kohl P, Sachs F, Franz MR, editors: Cardiac Mechano-Electric Coupling and Arrhythmias, Oxford, 2011, Oxford University Press, ...

Cardiac Electrophysiology  From Cell to Bedside E Book

Cardiac Electrophysiology: From Cell to Bedside puts the latest knowledge in this subspecialty at your fingertips, giving you a well-rounded, expert grasp of every cardiac electrophysiology issue that affects your patient management. Drs. Zipes, Jalife, and a host of other world leaders in cardiac electrophysiology use a comprehensive, multidisciplinary approach to guide you through all of the most recent cardiac drugs, techniques, and technologies. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Get well-rounded, expert views of every cardiac electrophysiology issue that affects your patient management from preeminent authorities in cardiology, physiology, pharmacology, pediatrics, biophysics, pathology, cardiothoracic surgery, and biomedical engineering from around the world. Visually grasp and easily absorb complex concepts through an attractive full-color design featuring color photos, tables, flow charts, ECGs, and more! Integrate the latest scientific understanding of arrhythmias with the newest clinical applications, to select the right treatment and management options for each patient. Stay current on the latest advancements and developments with sweeping updates and 52 NEW chapters - written by many new authors - on some of the hottest cardiology topics, such as new technologies for the study of the molecular structure of ion channels, molecular genetics, and the development of new imaging, mapping and ablation techniques. Get expert advice from Dr. Douglas P. Zipes - a leading authority in electrophysiology and editor of Braunwald’s Heart Disease and the Heart Rhythm Journal - and Dr. Jose Jalife - a world-renowned leader and researcher in basic and translational cardiac electrophysiology. Access the full text online at Expert Consult, including supplemental text, figures, tables, and video clips.

Cardiac Electrophysiology From Cell to Bedside E Book

Mechano-Electric Coupling and Arrhythmias. Oxford: Oxford 21. University Press; 2011:325–239. Kohl P, Nesbitt AD, Cooper PJ, et al. Sudden cardiac death by commotio cordis: role of mechano-electric feedback. Cardiovasc Res.

Cardiac Electrophysiology  From Cell to Bedside E Book

Rapid advancements in cardiac electrophysiology require today’s health care scientists and practitioners to stay up to date with new information both at the bench and at the bedside. The fully revised 7th Edition of Cardiac Electrophysiology: From Cell to Bedside, by Drs. Douglas Zipes, Jose Jalife, and William Stevenson, provides the comprehensive, multidisciplinary coverage you need, including the underlying basic science and the latest clinical advances in the field. An attractive full-color design features color photos, tables, flow charts, ECGs, and more. All chapters have been significantly revised and updated by global leaders in the field, including 19 new chapters covering both basic and clinical topics. New topics include advances in basic science as well as recent clinical technology, such as leadless pacemakers; catheter ablation as a new class I recommendation for atrial fibrillation after failed medical therapy; current cardiac drugs and techniques; and a new video library covering topics that range from basic mapping (for the researcher) to clinical use (implantations). Each chapter is packed with the latest information necessary for optimal basic research as well as patient care, and additional figures, tables, and videos are readily available online. New editor William G. Stevenson, highly regarded in the EP community, brings a fresh perspective to this award-winning text.

Zipes and Jalife s Cardiac Electrophysiology From Cell to Bedside E Book

Cardiac Mechano- Electric Coupling and Arrhythmias, ed 2. Oxford: Oxford University Press; 2011. 20. Herum KM, Choppe J, Kumar A, et al. Mechanical regulation of cardiac fibroblast profibrotic phenotypes. Mol Biol Cell.

Zipes and Jalife   s Cardiac Electrophysiology  From Cell to Bedside  E Book

Fully updated from cover to cover, Zipes and Jalife’s Cardiac Electrophysiology: From Cell to Bedside, 8th Edition, provides the comprehensive, multidisciplinary coverage you need—from new knowledge in basic science to the latest clinical advances in the field. Drs. José Jalife and William Gregory Stevenson lead a team of global experts who provide cutting-edge content and step-by-step instructions for all aspects of cardiac electrophysiology. Packs each chapter with the latest information necessary for optimal basic research as well as patient care. Covers new technologies such as CRISPR, protein research, improved cardiac imaging, optical mapping, and wearable devices. Contains significant updates in the areas of molecular biology and genetics, iPSCs (induced pluripotent stem cells), embryonic stem cells, precision medicine, antiarrhythmic drug therapy, cardiac mapping with advanced techniques, and ablation technologies including stereotactic radioablation. Includes 47 new standalone chapters that are organized into discrete topics for improved access. Discusses extensive recent progress in the understanding, diagnosis, and management of arrhythmias, including new clinical insights on atrial fibrillation and stroke prevention, new advances in the understanding of ventricular arrythmias in genetic disease, and advances in implantable devises and infection management. Features 1,600 high-quality photographs, anatomic and radiographic images, electrocardiograms, tables, algorithms, and more., with additional figures, tables, and videos online. Recipient of a 2018 Highly Commended award from the British Medical Association.

Atrial Fibrillation Update A Textbook of Cardiology

Cardiac mechano-electric coupling and arrhythmias. Oxford University press. 2011. p. 168. Kalifa J, Jalife J, Zaitsev AV, etal. Intra-atrial pressure increases rate and organization of waves emanating from the superior pulmonary veins ...

Atrial Fibrillation Update  A Textbook of Cardiology

Atrial fibrillation is a heart condition that causes an irregular and often abnormally fast heart rate. It can cause problems including dizziness, shortness of breath and tiredness and a patient may be aware of noticeable heart palpitations, where the heart feels like it is pounding, fluttering or beating irregularly, often for a few seconds or, in some cases, a few minutes (NHS Choices). This comprehensive guide presents clinicians with the latest developments in the diagnosis and management of atrial fibrillation. Divided into seven sections, the book covers clinical spectrum, diagnosis, therapeutic strategies, interventions, and new technologies used in its treatment and prevention. Complete sections are dedicated to other arrhythmias, to cardiac surgery and to future directions in atrial fibrillation. With more than 1000 pages providing in depth coverage of the topic, this manual is further enhanced by clinical photographs, diagrams and tables. Key Points Comprehensive guide to latest developments in diagnosis and treatment of atrial fibrillation More than 1000 pages discuss clinical spectrum, diagnosis, treatment options, interventions, and new technologies Complete sections dedicated to other arrhythmias, cardiac surgery, and future directions Highly illustrated with clinical photographs, diagrams and tables

Tissue Elasticity Imaging

... Cardiac Mechano-Electric Coupling and Arrhythmias, second ed., 2014. [32] W.N. Lee, C.M. Ingrassia, S.D. Fung-Kee-Fung, K.D. Costa, J.W. Holmes, E.E. Konofagou, Theoretical quality assessment of myocardial elastography with in vivo ...

Tissue Elasticity Imaging

Tissue Elasticity Imaging: Volume Two: Clinical Applications offers an extensive treatment of the fundamentals and applications of this groundbreaking diagnostic modality. Techniques and results are presented for the assessment of breast, prostate, heart, liver and thyroid tissues. For each application, details are provided on how to perform each technique, along with methods of interpretation, diagnostic criteria, quality assurance, challenges and case studies. This book is an essential resource for all researchers and practitioners (including scientists, radiologists, urologists, fellows and residents) interested in any elasticity imaging modality. As many diseases, including cancers, alter tissue mechanical properties, it is not always possible for conventional methods to detect changes, but with elasticity images that are produced by slow tissue deformation or low-frequency vibration, these changes can be displayed. Offers the first comprehensive reference on elasticity imaging Discusses the fundamentals of technology and their limitations and solutions, along with advanced methods and future directions Addresses the technologies and applications useful to both researchers and clinical practitioners Includes an online reference section regularly updated with advances in technology and applications

A Parametric Framework for Modelling of Bioelectrical Signals

Accessed 28 Nov 2014 Kohl, P., Sachs, F., Franz, M.R.: Cardiac Mechano-Electric Coupling and Arrhythmias. Oxford University Press, Oxford. http://books.google.com/books?id=AgoBCHptrFYC&pgis=1. Accessed 26 Nov 2014 Krivošei, ...

A Parametric Framework for Modelling of Bioelectrical Signals

This book examines non-invasive, electrical-based methods for disease diagnosis and assessment of heart function. In particular, a formalized signal model is proposed since this offers several advantages over methods that rely on measured data alone. By using a formalized representation, the parameters of the signal model can be easily manipulated and/or modified, thus providing mechanisms that allow researchers to reproduce and control such signals. In addition, having such a formalized signal model makes it possible to develop computer tools that can be used for manipulating and understanding how signal changes result from various heart conditions, as well as for generating input signals for experimenting with and evaluating the performance of e.g. signal extraction methods. The work focuses on bioelectrical information, particularly electrical bio-impedance (EBI). Once the EBI has been measured, the corresponding signals have to be modelled for analysis. This requires a structured approach in order to move from real measured data to the model of the corresponding signals. This book proposes a generic framework for this procedure. It can be used as a guide for modelling impedance cardiography (ICG) and impedance respirography (IRG) signals, as well as for developing the corresponding bio-impedance signal simulator (BISS).

Current Issues and Recent Advances in Pacemaker Therapy

[24] Zbilut JP, Webber CL Jr, Zak M (1998) Quantification of Heart Rate Variability using Methods Derived from nonlinear Dynamics. ... [30] Kohl P, Sachs F, Franz MR (2011) Cardiac Mechano-Electric Coupling and Arrhythmias.

Current Issues and Recent Advances in Pacemaker Therapy

Patients with implanted pacemakers or defibrillators are frequently encountered in various healthcare settings. As these devices may be responsible for, or contribute to a variety of clinically significant issues, familiarity with their function and potential complications facilitates patient management. This book reviews several clinically relevant issues and recent advances of pacemaker therapy: implantation, device follow-up and management of complications. Innovations and research on the frontiers of this technology are also discussed as they may have wider utilization in the future. The book should provide useful information for clinicians involved in the management of patients with implanted antiarrhythmia devices and researchers working in the field of cardiac implants.

Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias

Heart Circ. Physiol. 300, H2230–H2237. doi: 10.1152/ajpheart.01226.2010 Benson, A. P., Al-Owais, ... Cardiac Mechano-Electric Coupling and Arrhythmias. 2nd Edn. New York, NY: Oxford University Press. Kongstad, O., Yuan, S., Hertervig, ...

Remodeling of cardiac passive electrical properties and susceptibility to ventricular and atrial arrhythmias

The effective management of cardiac arrhythmias, either of atrial or of ventricular origin, remains a major challenge. Sudden cardiac death due to ventricular tachyarrhythmias remains the leading cause of death in industrialized countries while atrial fibrillation is the most common rhythm disorder; an arrhythmia that’s prevalence is increasing and accounts for nearly one quarter of ischemic stokes the elderly population. Yet, despite the enormity of the problem, effective therapeutic interventions remain elusive. In fact, several initially promising antiarrhythmic agents were found to increase rather than decrease mortality in patients recovering from myocardial infarction. The question then is what went wrong, why have these interventions proven to be so ineffective? An obvious answer is the drugs were designed to attack the wrong therapeutic target. Clearly, targeting single ion channels (using either isolated ion channels or single myocytes preparations) has proven to be less than effective. What then is the appropriate target? It is well established that cardiac electrical properties can vary substantially between single cells and intact preparations. One obvious example is the observation that action potential duration is much longer in isolated cells as compared to multi-cellular preparations or intact hearts. Due to the low electrical resistance between adjacent myocytes, the cells act in coordinated fashion producing “electrotonic interdependence” between neighboring cells. Myocardial infarction and/or acute ischemia provoke profound changes in the passive electrical properties of cardiac muscle. In particular, electrotonic uncoupling of the myocytes disrupts the coordinated activation and repolarization of cardiac tissue. The resulting compensatory changes in ionic currents decrease cardiac electrical stability increasing the risk for life-threatening changes in the cardiac rhythm. Thus, the electrical properties of myocardial cells must be considered as a unit rather than in isolation. It is the purpose of this Research Topic to evaluate the largely neglected relationship between changes in passive electrical properties of cardiac muscle and arrhythmia formation.

Heart Rate and Rhythm

Ventricular fibrillation during acute coronary occlusion is related to the dilation of the ischemic region. Basic Res Cardiol. 2002;97:445–51. 53. Chorro FJ, Trapero I, ... Cardiac mechano-electric coupling and arrhythmias. 2nd ed.

Heart Rate and Rhythm

Pathological heart rhythms are a major health issue. In this book experts from various fields provide an important context for understanding the complicated molecular and cellular mechanisms that underlie normal and pathophysiological cardiac rhythms. Individual chapters cover a full range of topics, including the ionic basis of pacemaking, the role of specific channels and transporters in sinoatrial node pacemaking, altered intracellular Ca2+ handling in response to disease, computer modeling of the action potentials of pacemaker and working cardiomyocytes, genetic and molecular basis of inherited arrhythmias and a review of established and novel antiarrhythmic agents. Due to the key importance of the specialized pacemaker cells and tissue (sinoatrial and atrioventricular nodes) in maintaining heart rate and rhythm, special emphasis is placed on the peculiar electrophysiology of these cells.

Clinical Aspects of Cardiac Arrhythmias

No conduction delay was induced by this technique, and no spontaneous arrhythmia occurred. ... Mechano-electrical coupling As in the case of electrotonic interaction, this mechanism is a possible but unproven source of ectopic activity.

Clinical Aspects of Cardiac Arrhythmias

We were particularly pleased to compile this volume entitled 'Clinical Aspects of Cardiac Arrhythmias'. Recent years have seen the publication of many textbooks on cardiac arrhythmias, some of which concentrate on one particular aspect such as drug management, electrocardiographic appearances, electrophysiological evaluation etc; and others of which are the collated reports of symposia, often dealing with detailed con siderations of highly specialised problems. Most of the larger more comprehensive texts have devoted a substantial proportion to basic considerations and experimental observations, far removed from the clinical arena. When asked to contribute to the series 'Current Status of Clinical Cardiology' we felt that the clinical aspects of cardiac arrhyth mias should be emphasized, and that the text should be as comprehensive as possible within the limitations of a single volume in this series. This comprehensive but clinical approach has necessitated the inclusion of certain subjects such as the mechanisms of tachycardia, metabolic aspects of cardiac arrhythmias and reperfusion arrhythmias, which are not directly or exclusively clinical. However, the rapid advances in these areas in recent years are likely to have increasingly important clinical con seq uences. Although the epidemiology of clinical arrhythmias is difficult to dis cover, it is widely appreciated that arrhythmias are commonplace.

Cardiac Arrhythmias Pacing Electrophysiology

High blood pressure and ventricular arrhythmias. Eur Heart J 1993; 14:1548–53. Lab MJ. Contribution of mechano-electric coupling to ventricular arrhythmias during reduced perfusion. Int J Microcirc Clin Exp 1989;8:433–42.

Cardiac Arrhythmias  Pacing   Electrophysiology

Europace '97 was held in Athens, Greece, on 8-11 June Leads were, as usual, an important topic, with the earl 1997 in the city of classical civilisation and learning. iest mention of the then-new polyurethane leads. Future Though now held in modem surroundings and meeting conferences elaborated on these basic topics while pro facilities, the influence of the ancient city-state was un gressively adding sensors and sensor function, dual mistakable, with the architecture and learning of antiquity chamber pacing, and recognising the development of looming over the city, by its influence over the intellectual clinical cardiac electrophysiology. activities of the symposium. The ancient magnificence of Clinical cardiac electrophysiology and compre the site was matched by the novelty of modem art and hension of arrhythmias has been largely a development science, Europace is a European symposium, begun in of the twentieth century. With the description and 1979, and has occurred every second year since. Con recording of the bundle of His depolarisation, by direct sistent with its importance and continental reach the actual access and by catheter, modem clinical investigation of symposium has moved to different cities throughout arrhythmias and cardiac electrophysiology began. The Western Europe. The first symposium was held in London disciplines of cardiac stimulation and of investigation of and subsequent symposia have been held in Torremolinos, arrhythmias, impulse formation and A V conduction Ostend, Florence, Istanbul and other cities. Because of the were essentially separate for many years.

Atrial Fibrillation An Issue of Cardiology Clinics E Book

Cardiac mechano-electric coupling and arrhythmias. Oxford, UK: Oxford University Press; 2011. p. 168. Franz MR, Bode F. Mechano-electrical feedback underlying arrhythmias: the atrial fibrillation case. Prog Biophys Mol Biol 2003 ...

Atrial Fibrillation  An Issue of Cardiology Clinics  E Book

Atrial fibrillation is the most common cardiac arrhythmia. This issue of Cardiology Clinics examines following facets of atrial fibrillation: epidemiology and societal impact, risk factors and genetics, mechanisms, diagnosis and follow-up, rate versus rhythm control, antiarrhythmic drug therapy, catheter ablation, surgery, antithrombotic and anticoagulant therapy, left atrial appendage exclusion, management of patients with heart failure and structural heart disease, and novel treatment paradigms.

Interpreting Complex Arrhythmias Part III An Issue of Cardiac Electrophysiology Clinics

European Heart Rhythm Association (EHRA) consensus document on the management of supraventricular arrhythmias, ... Schaefer J, Wilder N. Mechanosensitivity: from Aristotle's sense of touch to cardiac mechano-electric coupling.

Interpreting Complex Arrhythmias  Part III  An Issue of Cardiac Electrophysiology Clinics

This issue of Cardiac Electrophysiology Clinics, Guest Edited by Giuseppe Bagliani, Roberto De Ponti, and Fabio Leonelli, will focus on Interpreting Complex Arrhythmias. Topics include, but are not limited to: Simple and complex Arrhythmias; Standard ECG recording; Advanced cardiac signal recording; P and QRS in arrhythmias: identification, analysis and relationship; The comparative value of basic and arrhythmia ECG in the interpretation of arrhythmic mechanism; Challenges in Bradycardias interpretation; Challenges in Narrow QRS tachycardia interpretation; Challenging cases of Wide complex tachycardias; QRS variations during arrhythmia: mechanisms and substrates; Polymorphic ventricular tachycardia: differential diagnosis; Arrhythmias due to acquired or inherited abnormalities of Ventricular repolarization; Arrhythmias in patients with implantable devices; Complex arrhythmias due to reversible causes; and Hidden complexities in routine adult and paediatric arrhythmias interpretation.

Encyclopedia of Cardiovascular Research and Medicine

Heart and Circulatory Physiology307: H1327–H1338. Lakatta EG and Difrancesco D (2009) ... Journal of Molecular and Cellular Cardiology 47: 157–170. Lakatta EG, Maltsev VA, ... Cardiac Mechano-Electric Coupling and Arrhythmias, 2nd edn.

Encyclopedia of Cardiovascular Research and Medicine

Encyclopedia of Cardiovascular Research and Medicine offers researchers over 200 articles covering every aspect of cardiovascular research and medicine, including fully annotated figures, abundant color illustrations and links to supplementary datasets and references. With contributions from top experts in the field, this book is the most reputable and easily searchable resource of cardiovascular-focused basic and translational content for students, researchers, clinicians and teaching faculty across the biomedical and medical sciences. The panel of authors chosen from an international board of leading scholars renders the text trustworthy, contemporary and representative of the global scientific expertise in these domains. The book's thematic structuring of sections and in-depth breakdown of topics encourages user-friendly, easily searchable chapters. Cross-references to related articles and links to further reading and references will further guide readers to a full understanding of the topics under discussion. Readers will find an unparalleled, one-stop resource exploring all major aspects of cardiovascular research and medicine. Presents comprehensive coverage of every aspect of cardiovascular medicine and research Offers readers a broad, interdisciplinary overview of the concepts in cardiovascular research and medicine with applications across biomedical research Includes reputable, foundational content on genetics, cancer, immunology, cell biology and molecular biology Provides a multi-media enriched color-illustrated text with high quality images, graphs and tables.

Theory of Heart

Biomechanics, Biophysics, and Nonlinear Dynamics of Cardiac Function Leon Glass, Peter Hunter, Andrew McCulloch. [60] M.J. Lab. Contribution of mechano-electric coupling to ventricular arrhythmias during reduced perfusion.

Theory of Heart

In recent years there has been a growth in interest in studying the heart from the perspective of the physical sciences: mechanics, fluid flow, electromechanics. This volume is the result of a workshop held in July 1989 at the Institute for Nonlinear Sciences at the University of California at San Diego that brought together scientists and clinicians with graduate students and postdoctoral fellows who shared an interest in the heart. The chapters were prepared by the invited speakers as didactic reviews of their subjects but also include the structure, mechanical properties, and function of the heart and the myocardium, electrical activity of the heart and myocardium, and mathematical models of heart function.

Recent Developments in Cancer Systems Biology

Kohl, P.; Sachs, F.; Franz, M.R. Cardiac Mechano-Electric Coupling and Arrhythmias; Oxford University Press: Oxford, UK, 2011. 30. Bindea, G.; Mlecnik, B.; Hackl, H.; Charoentong, P.; Tosolini, M.; Kirilovsky, A.; Fridman, W.H.; Pagès, ...

Recent Developments in Cancer Systems Biology

This book includes original research articles and reviews to update readers on the state of the art systems approach to not only discover novel diagnostic and prognostic biomarkers for several cancer types, but also evaluate methodologies to map out important genomic signatures. In addition, therapeutic targets and drug repurposing have been emphasized for a variety of cancer types. In particular, new and established researchers who desire to learn about cancer systems biology and why it is possibly the leading front to a personalized medicine approach will enjoy reading this book.

Channelopathies in Heart Disease

Quinn TA, Kohl P. Rabbit models of cardiac mechano-electric and mechano-mechanical coupling. ... M. Simultaneous non-invasive epicardial and endocardial mapping in patients with Brugada syndrome: new insights into arrhythmia mechanisms.

Channelopathies in Heart Disease

This book provides an expert overview on ion channel-related arrhythmia mechanisms, and describes important advances in our understanding of how ion channel dysfunction causes cardiac disease. Both, scientific findings and clinical implications are presented and discussed by scientists who have considerably contributed to the field. The book is organized in three parts: part I treats the molecular and electrophysiological mechanisms of function and dysfunction of ion channels, part II focuses on genetics and clinical findings, whereas part III describes novel research techniques, the use of stem cells and animal models and provides an outlook on future investigations and applications. The book is written for scientists in Cardiovascular Biology and Neuroscience and will be of general interest to Medical Doctors in Cardiology, Cardiac Electrophysiology and related disciplines.