Charnolophagy in Health and Disease

This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, ΔΨ collapse, and ATP ...

Charnolophagy in Health and Disease

This book introduces charnolophagy (CP) as energy-driven, lysosomal-dependent mitochondrial inclusion-specific pleomorphic Charnoly body (CB) autophagy (ATG) involving free radical-induced Ca2+ dyshomeostasis, ΔΨ collapse, and ATP depletion in congenital diseases, pressure ulcers, metabolic diseases, hepatic diseases, diabetes, obesity, inflammatory diseases, musculoskeletal diseases, sarcopenia, cachexia, respiratory diseases, gastrointestinal diseases, hyperlipidemia, skin and hair diseases, pulmonary diseases, cardiovascular diseases, renal diseases, sepsis-induced multi-organ failure, reproductive diseases, inflammatory diseases, ophthalmic diseases, neurodegenerative diseases, drug addiction, aging, microbial (including COVID-19) infections, and belligerent malignancies implicated in early morbidity and mortality and disease-specific spatiotemporal, targeted, safe, and effective evidence-based personalized theranostic charnolopharmacotherapeutics to cure them. Basic DRESS and GELS principles, nanoparticles to cure chronic multidrug-resistant (MDR) diseases, antioxidants as free radical scavengers, CB antagonists, CP regulators, and CS stabilizers to curb CB molecular pathogenesis (CBMP) are described for better quality of life and longevity. Specific guidelines for environmental protection and preservation of zoological and botanical species at the verge of extinction, Triple "I" Hypothesis for mitochondrial quality control, and transcriptional regulation of CSexR and CSendoR to cure chronic diseases are presented. Novel CP index is introduced to evaluate MDR malignancies and other chronic diseases. WHO, CDC, FDA, NIH, policy planners, cosmetologists, trichologists, players, athletes, dancers, wrestlers, equestrians, young women, aging population, toxicologists, environmental protectionists, pharmaceutical industry, biomedical scientists, researchers, medical students, physicians, nurses, paramedical professionals, and global audience will be interested in this interesting book to prevent pandemics and raise healthcare awareness.

The Charnoly Body

Whether, charnolophagy occurring during fertilization, is similar to progressive NDDs such as MS, PA, PD, HD, MSA, PDD, HD, ALS, remains uncertain. In fact, the intracellular microenvironment of ... fertilization in health and disease.

The Charnoly Body

Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners.

The Charnoly Body

The book will be of interest to medical scientists and practitioners.

The Charnoly Body

Diversified physicochemical injuries trigger Charnoly body (CB) formation as pleomorphic, electron-dense, multi-lamellar stacks of nonfunctional mitochondrial membranes in the most vulnerable cell. Free radicals induce downregulation of mitochondrial DNA, microRNA, AgNOR, and epigenetics to trigger CB molecular pathogenesis. CB is eliminated by energy (ATP)-driven lysosome-dependent charnolophagy as a basic molecular mechanism of intracellular detoxification to prevent acute and chronic diseases. Accumulation of CB at the junction of axon hillock and charnolosome (CS) at the synapses causes cognitive impairments; whereas, nonspecific induction of CB causes GIT stress, myelosuppression, alopecia, neurotoxicity, cardiotoxicity, and infertility in multidrug-resistant malignancies. Hence, stem cell-specific CB, charnolophagy, and CS agonists/antagonists are introduced as novel charnolopharmacotherapeutics for the successful treatment of cardiovascular diseases, neurodegenerative diseases, infectious diseases, drug addiction, and cancer. Nanoparticles to improve drug delivery, CS exocytosis, and disease-specific spatiotemporal charnolosomics employing correlative and combinatorial bioinformatics boost mitochondrial bioenergetics through balanced diet, exercise, and antioxidants. The book will be of interest to medical scientists and practitioners.

Zika Virus Disease

This book describes unique organ and disease-specific Charnoly body (CB) inhibitors, charnolophagy inducers, CB sequestration inhibitors, and chanolophagosome stabilizers as promising charnolopharmacotherapeutics.

Zika Virus Disease

The author was motivated to write this important book because currently there is no systematically-written document on the ZIKV disease, which could serve at this crucial moment as a textbook for medical students, physicians, nurses, and other healthcare providers as well as a reference book for basic researchers, professors, and the general public. The original concept of ZIKV-Charnolopathy due to compromised mitochondrial bioenergetics in highly vulnerable (neural progenitor cells, spermatocytes, oocytes etc.) cells and its amelioration by physiological and/or pharmacological interventions is based on years of research experience. This book describes unique organ and disease-specific Charnoly body (CB) inhibitors, charnolophagy inducers, CB sequestration inhibitors, and chanolophagosome stabilizers as promising charnolopharmacotherapeutics. They are meant to aid in the prevention and treatment of the ZIKV-linked diversified spectrum of neurodevelopmental anomalies (embryopathies) in newborn infants and Guillain Barre' Syndrome (GBS) in adults. Clinical management of ZIKV-induced GBS employing IV immunoglobulin and plasmapheresis (plasma exchange) is also described.

Nicotinism and the Emerging Role of E cigarettes With Special Reference to Adolescents

This book is written primarily for readers interested in learning more about the basic molecular biology, recent biotechnology, and molecular genetics for diseases linked to nicotinism as well as their possible prevention and cure.

Nicotinism and the Emerging Role of E cigarettes With Special Reference to Adolescents

Nova Science Publishers now introduce an interesting book on research to help reduce global tobacco-related diseases in four volumes. Volume One describes general topics on nicotinism and the emerging role of electronic cigarettes; Volume Two describes basic molecular biology of nicotinism; Volume Three describes emerging biotechnology in nicotinism; and Volume Four describes chronic diseases associated with nicotinism and disease-specific-spatiotemporal (DSST) charnolosomics and charnolopharmacotherapeutics for the targeted, safe and effective personalized theranostics of nicotinism. This book is written primarily for readers interested in learning more about the basic molecular biology, recent biotechnology, and molecular genetics for diseases linked to nicotinism as well as their possible prevention and cure. A novel disease-specific spatiotemporal charnolosomics along with conventional omics (genomics, proteomics, metabolomics, lipidomics, and metallomics) with correlative and combinatorial bioinformatic analysis is proposed for the first time to accomplish targeted, safe, and effective personalized theranostics of nicotinism for a better quality of life. This book is written primarily for the health and well-being of highly vulnerable adolescents, who engage in drug seeking behavior (particularly tobacco and alcohol), become victims of chronic addiction, and suffer from poor quality of life, early morbidity, and mortality. Moreover, nicotine exposure during intrauterine life can induce diversified embryopathies (such as abortion, stillbirth, sudden infant death syndrome, microcephaly, craniofacial abnormalities, growth retardation, ADHD, autism, and craniofacial abnormalities) in developing infants; likewise, asthma, COPD, cancer, and infertility occurs in adults. The primary goal is to minimize nicotine-induced early morbidity and mortality due to asthma, emphysema, cancer, heart attack, diabetes, obesity, infertility, major depressive disorders, schizophrenia, Alzheimers disease, and several other neurological and neuropsychiatric disorders, which are elegantly described in this book. Volumes Three describes emerging biotechnology in nicotinism in three sections: Section One illustrates emerging biotechnology in nicotinism, consisting of eight chapters: Chapter One Evaluation of Nicotinism by Flow Cytometry and Other Emerging Biotechnology (Molecular Neuroimaging); Chapter Two Mitochondrial Bioenergetics and Immunophenotyping of Nicotinism (A Flow Cytometric Analysis of Charnoly Body Dynamics in Nicotinism); Chapter Three Flow Cytometric Analysis of Charnolophagy and Charnolosome Exocytosis/Endocytosis in Nicotinism; Chapter Four Mass Spectrometric Analysis of Nicotine and Nicotinism; Chapter Five Pet Neuroimaging in Nicotinism (With Special Reference to Nicotinic Acetyl Choline Receptor Imaging); Chapter Six Multimodality Molecular Neuroimaging in Nicotinism; Chapter Seven Personalized Theranostic Potential of Nanomedicine in Nicotinism; and Chapter Eight Mitochondrial Bioenergetics and Charnolopharmacotherapeutics in Nicotinism. Section Two: Disease-Specific Personalized Theranostics of Nicotinism highlights disease-specific personalized theranostics of nicotinism in Chapter Nine, and Section Three: Clinical Management of Nicotinism details harmful aspects and therapeutic benefits of nicotine in Chapter Ten. While each volume will serve as a textbook for biomedical students and as a reference book for researchers, scientists, doctors, and professors, all four of the volumes systematically will certainly enhance the existing knowledge and wisdom regarding nicotinism and drug addiction in general. It is envisaged that readers (researchers, doctors, nurses, teachers, students (particularly high school and college students) and the general public will enjoy learning the most recent and novel personalized theranostic approaches currently being implemented in this clinically-significant discipline by carefully going through the most interesting and thought-provoking contents of this book.

Sustained Energy for Enhanced Human Functions and Activity

Hence the term “charnolophagy” should not be used indiscriminately and misinterpreted with general “autophagy. ... the term “charnolophagy” will be more specific to these and other organs and diseases associated with these organs.

Sustained Energy for Enhanced Human Functions and Activity

Sustained Energy for Enhanced Human Functions and Activity addresses the basic mechanistic aspects of energy metabolisms, the chemistry, biochemistry and pharmacology of a variety of botanical ingredients, micronutrients, antioxidants, amino acids, selected complexes, and other nutracueticals which have demonstrated a boost in and the sustainability of functional energy. The role of exercise and physical activity is also discussed, and the conclusion addresses paradigm shifts in the field and envisions the future. Intended for researchers and industry professionals, the book is as an essential reference on the impact of proper nutrient balance on sustained energy. Serves as a comprehensive reference on natural products that can boost and sustain energy Encompasses information on diverse energy ingredients and their potential role in optimal health and sustained energy Conceptualizes the key features in diverse nutraceuticals that can boost sustained energy and well-being Presents the intricate mechanistic aspects and balance between optimal and sustained energy Addresses the pathophysiology and mechanistic insight of diverse nutraceuticals and functional foods that can help in maintaining optimal health and sustain functional energy

Fetal Alcohol Spectrum Disorders

In this book the author has presented the novel concept of charnolopharmacology, which plays a crucial role in determining the life and death of the foetus during intrauterine foetal alcohol exposure (FAE).

Fetal Alcohol Spectrum Disorders

Alcoholism exerts a high genetic as well as epigenetic load and may be regarded as one of the most prevalent, identifiable, and preventable neuropsychiatric illnesses afflicting modern society today. Alcohol constituted 3.2% of all worldwide deaths in the year 2006 and is associated with >60 diseases, including foetal alcohol spectrum disorder (FASD), cancers, cardiovascular diseases, liver cirrhosis, neuropsychiatric disorders and life-threatening injuries. Fatal alcohol spectrum disorder (FASD) is a collective term representing foetal abnormalities associated with maternal alcohol abuse. FASD is a devastating developmental disorder resulting from alcohol exposure during foetal development. It is a considerable public health problem worldwide and is characterised by CNS abnormalities, dysmorphic facial features, and growth deficiency. Although it is well-established that intra-uterine alcohol exposure can lead to FASD, characterised by cognitive and behavioural impairments, alcohol abuse is still highly prevalent and contributes to a significant loss of economy and productivity throughout the entire world. Children with FASD become a serious and persistent socioeconomic burden to society, as they require specialised healthcare liabilities throughout their entire lives as a consequence of their parents irresponsible drinking behaviour. The primary aim of the inter-disciplinary and integrated genome research network (consisting of molecular biologists, psychopharmacologists, system biologists with mathematicians, human geneticists, and clinicians) is to better understand the genetics and epigenetics of alcohol addiction by identifying candidate genes and molecular mechanisms involved in the etiopathogenesis of FASD, and to provide recommendations to the government and scientific community for global dissemination of emerging knowledge and implementation of FASD interventions. In this book the author has presented the novel concept of charnolopharmacology, which plays a crucial role in determining the life and death of the foetus during intrauterine foetal alcohol exposure (FAE). More specifically, it proposes mitochondrial bioenergetics-based charnolopharmacotherapeutics for personalised theranostics of FASD, involving diversified charnolopathies, embryopathies, and infertility; resulting in poor quality of life. Although several concepts, mechanisms and potential therapies have been proposed recently to overcome the deleterious consequences of FASD, the author has now proposed charnolopharmacotherapeutics, which is based on ethanol-induced compromised mitochondrial bioenergetics and the induction of charnolopathies initially in the spermatocyte and oocyte during the prezygotic phase, and subsequently in the neural progenitor cells (NPCs) during the post-zygotic phase of pregnancy. Hence, drugs inhibiting CB formation and/or augmenting charnolophagy as a basic molecular mechanism of intracellular detoxification during the acute phase, stabilising charnolophagosome and preventing charnolosome sequestration and budding during chronic phase, will have therapeutic potential in FASD embryopathies, which is elegantly described in this book. The most unique feature of this book is that it introduces original concepts of mitochondrial bioenergetics, genomics, and epigenomics to successfully manage FASD. Particularly, mitochondrial bioenergetics-based CB prevention/inhibition, charnolophagy induction, and charnolophagosome and charnolosome stabilisation are novel therapeutic targets for safe and effective clinical management of FASD. These concepts and mechanisms are based on several years of basic research and original discoveries by the author.