Cytokines in Hemopoiesis Oncology and AIDS II

This book is dealing with most recent advances in the field of cytokines in hemopoiesis, oncology and AIDS. It covers a wide range from basic research to clinical applications.

Cytokines in Hemopoiesis  Oncology  and AIDS II

This book is dealing with most recent advances in the field of cytokines in hemopoiesis, oncology and AIDS. It covers a wide range from basic research to clinical applications. Overviews on the biological role of cytokines are represented within the book as well as experiments with research on new cytokines and special effects of cytokines. The book will be of interestto hematologists and oncologists as well as imunologists who are engaged in the development of innovative therapy. It gives an overview on the most recent status of the discussion in this field.

Cytokines in Hemopoiesis Oncology and AIDS

Major contributions from the first sym posium are published in this book.

Cytokines in Hemopoiesis  Oncology  and AIDS

The clinical and experimental effects of cytokines have been realized for a long time. The clinical effects of tumor necrosis factor were noted almost 100 years ago. The basic biological effects of interferons and the hemopoietic growth factors have been known for more than 20 years. Given the basis of modern molecular biotechniques, information concern ing the mediators of cellular interactions is expanding almost exponentially. New principles in the regulation of cell growth, microenvironment, immune response, and malignancy are being discoverd right now. New therapeutic options are becoming available and have, in some areas, already crossed the threshold of clinical application. However, the way forward might be more complicated than we are in a position to recognize today. Some of the first optimistic expectations have not yet been fulfilled. Nevertheless, we are experiencing a revolution in medicine. To contribute to this process and to stimulate scientific communi in this field, we have initiated the international symposia on cytokines cation in hemopoiesis, oncology and aids. Major contributions from the first sym posium are published in this book. We thank all the authors for their contri butions, particularly those from the Hannover Medical School, who have worked hard to realize the congress and prepare these proceedings. We also thank the pharmaceutical companies whose support made this book possible. Finally we thank Professors Deicher, Poliwoda, and Riehm, heads of the Departments of Hematology and Oncology, Immunology, and Pediatric Hematology and Oncology, respectively, who encouraged us and gave us their firm support.

Cytokines in hemopoiesis oncology and AIDS

Cytokines in hemopoiesis  oncology and AIDS


AIDS Bibliography

Southwest Regional Hispanic AIDS Conference . San Antonio , Tex . : Hispanic AIDS Committee for Education and Resources , [ c1989 ) iv , 360 p BIOLOGICAL FACTORS THERAPEUTIC USE Cytokines in hemopoiesis , oncology , and AIDS II .

AIDS Bibliography


Cytokines in Hemopoiesis Oncology and Immunology III

( eds ) Cytokines in hemopoiesis , oncology and AIDS II . Springer , Berlin Heidelberg New York , pp 645-697 2. Moore MAS ( 1992 ) Hematopoiesis : an Introduction and overview . In : Freund M et al . ( eds ) Cytokines in hemopoiesis ...

Cytokines in Hemopoiesis  Oncology  and Immunology III


National Library of Medicine Current Catalog

9111930 Negative regulators of hematopoiesis : studies on their nature , action , and potential role in cancer therapy ... DRUG EFFECTS - CONGRESSES Cytokines in hemopoiesis , oncology , and AIDS / M. Freund , H. Link , K Welte ( eds . ) ...

National Library of Medicine Current Catalog


Immunological Alterations in Psychiatric Diseases

... Porzsolt F , Born J , Fehm HL : Differences in stimulated cytokine release between sleep and sleep deprivation ; in Freund M , Link H , Schmidt R , Welte K ( eds ) : Cytokines in Hemopoiesis , Oncology , and AIDS . II .

Immunological Alterations in Psychiatric Diseases

In addition, fundamental questions concerning the bi-directional interactions between the central nervous system and the immune system are discussed and the role of viruses and infectious processes closely examined. As such, this book offers a unique presentation of the state of the art in psychoimmunology and, at the same time, shows many important challenges for future research into the field of intersystemic interactions and their impact on the etiology and pathogenesis of psychiatric diseases.

Therapie der Leuk mien und Lymphome Schwerpunkt Zytokine

Literatur 1 2 3 4 5 6 7 8 9 10 11 Nowell PC , Hungerford DA : A minute chromosome in human granulocytic leukemia . ... in Freund M , Link H , Schmidt RE , Welte K ( eds ) : Cytokines in Hemopoiesis , Oncology , and AIDS II .

Therapie der Leuk  mien und Lymphome   Schwerpunkt Zytokine

Der vorliegende Band gibt einen aktuellen Überblick über die Therapie von Leukämien und Lymphomen, unter besonderer Berücksichtigung der Zytokine und deren pathogenetischer Bedeutung. Diskutiert wird der Einsatz hämatopoetischer Wachstumsfaktoren bei Hochdosis-Chemotherapie, autologer Knochenmarktransplantation sowie akuter myeloischer und lymphatischer Leukämie. Am Beispiel der chronischen myeloischen Leukämie und der niedrigmalignen Lymphome wird die Therapie mit Interferon-alpha erörtert, ebenso berücksichtigt wird die Behandlung mit Interleukin-2 und -3. Die grundsätzliche Therapie der chronisch myeloischen Leukämie, des M. Hodgkin sowie der niedrig- und hochmalignen Lymphome wird übersichtlich dargestellt; insbesondere wird auf das Zytostatikum Bendamustin eingegangen. Das Buch ist von besonderem Interesse für internistische Hämatologen und Onkologen in Klinik oder Spezialpraxis sowie für hämatologisch interessierte Internisten, die sich auf diesem Gebiet weiterbilden wollen.

Colony Stimulating Factors

Cytokines in Hemopoiesis, Oncology, and AIDS II. Berlin: Springer-Verlag, 1992:285-290. 89. Branch RB, Turner R, Guilbert LJ. Synergistic stimulation of macrophage proliferation by the monokines tumor necrosis factor-alpha and ...

Colony Stimulating Factors

Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.

Acute Leukemias IV

In: Freund M, Link H, Schmidt RE, Welte K (eds) Cytokines in hemopoiesis, oncology, and AIDS II. Springer Verlag, Berlin Heidelberg New York, pp 693–706 8. Freund M, von Wussow P, Diedrich H, Eisert R, Link H, Wilke H, Buchholz F (1989) ...

Acute Leukemias IV

The rates of acute leukemia cure have gradually improved over the last decade. Clinical study results reflect the impact of chemotherapy intensity and duration, the role of prolonged maintenance, intensified consolidation or very early intensification. Further progress has also been achieved in bone marrow trans plantation, and recent prospective studies and meta-analyses have contributed comparisons of the high antileukemic efficacy of bone marrow transplantation to that of improved chemotherapy. This allows a more successful combining of the two forms of treatment. New prognostic factors have emerged from both cytogenetic and molecular genetic research. Thus, the Philadelphia chromosome translocation and the bcr/abl gene rearrangement have proven to be the dominating risk factor in acute lymphoblastic leukemia. Since the frequency increases with age, differences in prognosis between children and adults can be explained. Evaluation of molecular and immunologic leukemia cell markers has provided a better understanding of residual leukemia in clinical remission, as a prognostic factor and in monitoring the effectiveness of the antileukemic strategy. Recent work on leukemic cell biology has resulted in novel therapeutic approaches such as terminal differentiation by all-trans-retinoic acid, modulation of chemotherapy by hematopoietic growth factors such as GM-CSF and enhancement of immunologic control by cytokines such as interleukin 2. New antimicrobial drugs and the application of mostly empiric anti-infectious strategies have helped reducing the therapeutic risk. Thus, a number of recent achievements have provided us with new options in the management of patients with acute leukemias.

Current Catalog

9306278 see Salfelder , Cytokines in hemopoiesis , oncology , and AIDS II / M. Freund ... [ et al . ] ( eds . ) . -- Berlin ; New York : Springer - Verlag , c1992 . li , 800 p . : ill . Includes bibliographical references and index .

Current Catalog

First multi-year cumulation covers six years: 1965-70.

Recent Advances in Cell Biology of Acute Leukemia

(eds) Cytokines in hemopoiesis, oncology, and AIDS II. Springer, Berlin Heidelberg, 171–178 Pietsch T, Kyas U, Steffens U, Yakisan E, Hadam MR, Ludwig W-D, Zsebo K, Welte K (1992b) Effects of human stem cell ...

Recent Advances in Cell Biology of Acute Leukemia

The development of new techniques such as immuno phenotyping, cytogenetic investigations and, more recently, molecular studies has considerably increased our diagnostic repertoire and broadened our ideas about the biology of acute leukemias. While immunophenotyping with mono clonal antibodies has yielded increased diagnostic precision and made it possible to develop a highly reproducible classification of acute leukemias based on cell-biological features, further insights have been gained into the patho genetic mechanisms involved in leukemogenesis by means of cytogenetic detection of acquired structural chromosomal abnormalities. Analysis of the leukemia-associated chromo somal breakpoints using molecular techniques can now pinpoint many genomic sites essential for normal develop ment and maturation of hematopoietic cells but functionally disrupted in leukemic cells. The main goal of the international workshop that we held in Berlin with a select group of scientists and clinicians involved in leukemia research was to describe the state of the art and new developments in the immunologic, cytogenetic, and molecular characterization of acute leukemias and to discuss the clinical importance of cell biological features. After introductory survey lectures dealing with the immunological and molecular-biological characteristics of normal vs. malignant lymphatic and myeloid progenitor cells, the workshop centered on con tributions characterizing the immunophenotype and both numerical and structural chromosomal abnormalities in acute leukemias.

Cancer Immunology Immunotherapy

... Spain C Wesselenvi u 28 , H 1075 Budapest , Hungary Relevance of the T cell receptor for immunotherapy of cancer ... Double - Stranded RNA and 2 ' , 5'Oligoadenylates Cytokines in Hemopoiesis , Oncology , and AIDS II 6 Springer ...

Cancer Immunology  Immunotherapy


German books in print

... and AIDS Welte , Karl Cytokines in Hemopoiesis , Oncology , and AIDS II Welte , Karl + Cytokines in Hemopoiesis , Oncology , and Immunology III ... Hochschulschr . , 2 , 1433 ) ' lang , Peter Frankfurt ' Br 69 , - + 3-631-46438 ...

German books in print


Cytokines

A phase II study of placebo versus recombinant human macrophage colonystimulating factor to augment antifungal therapy in patients with ... J. Natl Cancer Inst, 86, 120–126. ... In “Cytokines in Hemopoiesis, Oncology, and AIDS” (eds.

Cytokines

This book provides comprehensive coverage of the cytokines from a pharmacological approach. The chapters are presented in a consistent format allowing easy cross-reference, with sample diagrams and a summary table of essential facts for each chapter at the end of the book. Cytokines is unique in stressing cytokine biology and the application of research data to provide disease therapy. With 33 detailed and up-to-date chapters about individual cytokines, this comprehensive reference will provide both clinicians and researchers in immunology and pharmacology with invaluable information. Genetic information and sequences Protein structure Cell sources and production Biological activity Cytokine receptor structure and signal transduction Discussion of the role of cytokines in disease and the potential for therapy Summary table of essential facts Comprehensive bibliography

Journal of the National Cancer Institute

1 2 3 Il PDQ is your database of choice . ... Second International Symposium : Cytokines in Hemopoiesis , Oncology , and AIDS Hannover , Germany , June 19-22 , 1991 For further information , contact : Dr M. Freund , Dept of Hematology ...

Journal of the National Cancer Institute


Acute Leukemias V

Cytokines in hemopoiesis, oncology and AIDS. ... Cytokine Net. 1991, Vol 2, n° 2:121– 129. 6. Blaise D, Olive D, Brandely M, Stoppa AM, Gabus R, Tiberghien P. Use of recombinant interleukin2 (RU49637) after autologous bone marrow ...

Acute Leukemias V

150 years after the first description of the clinical picture of "white blood" and the introduction of the term "leukemia" by R. Virchow it appears, that the leukemias, and the acute leukemias in particular, serve as an impressive example for the major improvements that have been achieved in the treatment but also in the understand ing of the biology of malignant dis orders. The international symposia "Acute Leukemia" which are held at Münster since 1986 have developed into an interna tional forum to review the current progress and the future perspectives of leukemia research and therapy at a high scientific and clinicallevel. Since the possibility for active participation in these symposia is somewhat restricted we are glad to have the opportunity to extend the information that was presented at the symposium "Acute Leukemias V - Experimental Approaches and Management of Refractory Disease" which was held from February 27 to March 2, 1994 to a broader audience of basic scientists and clinicians. This meeting was especiaIly designed to discuss experimen tal approaches and the management of refractory disease which allows to evaluate new experimental therapies on the basis of preclinical studies.

Scientific Directory and Annual Bibliography

J Cell Biochem 1991 ; 45 : 1-2 . ... Cytokines in hemopoiesis , oncology and AIDS . ... localization of the gene for a human cytosolic thyroid hormone binding protein which is homologous to a subunit of pyruvate kinase , subtype 2.

Scientific Directory and Annual Bibliography

Each issue lists papers published during the preceding year.