Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition EMT and Fibrosis

TABLE 1 | Characteristics of lung tissue obtained from IPF and non-IPF donors for CK1δ/ε immunohistochemistry. ... Age Sex FEV1 (% pred) FVC (% pred) TLCO (% pred) Smoking history (pack yrs) Control patients 47.4 ± 16.7 (mean ± SD) ...

Molecular Mechanisms and New Therapeutic Targets in Epithelial to Mesenchymal Transition  EMT  and Fibrosis


Numerical Simulation of Pore scale Heterogeneity and Its Effects on Elastic Electrical and Transport Properties

For comparing Zimmer's data with single-cycle GD simulations and laboratory experiments (Domenico, 1977), we consider only the stress-strain values for virgin compaction zones. 35 1 .. Domenico with initial porosity 0.385 1 L.' "I" ...

Numerical Simulation of Pore scale Heterogeneity and Its Effects on Elastic  Electrical and Transport Properties

This dissertation describes numerical experiments quantifying the influence of pore-scale heterogeneities and their evolution on macroscopic elastic, electrical and transport properties of porous media. We design, implement and test a computational recipe to construct granular packs and consolidated microstructures replicating geological processes and to estimate the link between process-to-property trends. This computational recipe includes five constructors: a Granular Dynamics (GD) simulation, an Event Driven Molecular Dynamics (EDMD) simulation and three computational diagenetic schemes; and four property estimators based on GD for elastic, finite-elements (FE) for elastic and electrical conductivity, and Lattice-Boltzmann method (LBM) for flow property simulations. Our implementation of GD simulation is capable of constructing realistic, frictional, jammed sphere packs under isotropic and uniaxial stress states. The link between microstructural properties in these packs, like porosity and coordination number (average number of contacts per grain), and stress states (due to compaction) is non-unique and depends on assemblage process and inter-granular friction. Stable jammed packs having similar internal stress and coordination number (CN) can exist at a range of porosities (38-42%) based on how fast they are assembled or compressed. Similarly, lower inter-grain friction during assemblage creates packs with higher coordination number and lower porosity at the same stress. Further, the heterogeneities in coordination number, spatial arrangement of contacts, the contact forces and internal stresses evolve with compaction non-linearly. These pore-scale heterogeneities impact effective elastic moduli, calculated by using infinitesimal perturbation method. Simulated stress-strain relationships and pressure-dependent elastic moduli for random granular packs show excellent match with laboratory experiments, unlike theoretical models based on Effective Medium Theory (EMT). We elaborately discuss the reasons why Effective Medium Theory (EMT) fails to correctly predict pressure-dependent elastic moduli, stress-strain relationships and stress-ratios (in uniaxial compaction) of granular packs or unconsolidated sediments. We specifically show that the unrealistic assumption of homogeneity in disordered packs and subsequent use of continuum elasticity-based homogeneous strain theory creates non-physical packs, which is why EMT fails. In the absence of a rigorous theory which can quantitatively account for heterogeneity in random granular packs, we propose relaxation corrections to amend EMT elastic moduli predictions. These pressure-dependent and compaction-dependent (isotropic or uniaxial) correction factors are rigorously estimated using GD simulation without non-physical approximations. Further, these correction factors heuristically represent the pressure-dependent heterogeneity and are also applicable for amending predictions of theoretical cementation models, which are conventionally used for granular packs. For predicting stress-ratios in uniaxial compaction scenario, we show the inappropriateness of linear elasticity-based equations, which use elastic constants only and do not account for dissipative losses like grain sliding. We further implement and test a computational recipe to construct consolidated microstructures based on different geological scenarios, like sorting, compaction, cementation types and cement materials. Our diagenetic trends of elastic, electrical and transport properties show excellent match with laboratory experiments on core plugs. This shows the feasibility of implementing a full-scale computational-rock-physics-based laboratory to construct and estimate properties based on geological processes. However, the elastic property estimator (FE simulation) shows limitations of finite resolution while computing elastic properties of unconsolidated sediments and fluid-saturated microstructures.

Medical Electronic Laboratory Equipment 1967 68

18 O EMT 473a Three - way stopcock : internal thread external thread and right - hand side connection with ... 7 , has the following controls : 1 Time constant selector Five integrator time constants can be selected : 5 - 10 - 20 - 40 ...

Medical Electronic Laboratory Equipment  1967 68


Instruments Control Systems

52 ( 5 ) Wang Labs , Inc. 159 ( 7 ) , 42 ( 8 ) Ware , William E. ( author ) 79 ( 6 ) Warner Electric Brake & Clutch Co. ... 1 13 ( 6 ) Advances in Electronic Circuit Package ing . Vol . 3 13 ( 6 ) Advances In Tracer Methodology . Vol .

Instruments   Control Systems


Nancy Caroline s Emergency Care in the Streets Includes Navigate 2 Preferred Access Nancy Caroline s Emergency Care in the Streets Student Workbook

Volume 1 Assessment in Action Courtesy ofjason Pack/ FEMA Section Openers 2 © Victoria Alexandrova/ShutterStock, Inc.; 3 © Mark C. 1de;4 © Mark C. Ide; 5 © Mark C. Ide. Chapter 1 Opener © Mark C. Ide; 1-1 © Mark C. Ide; 1-2 © National ...

Nancy Caroline s Emergency Care in the Streets  Includes Navigate 2 Preferred Access   Nancy Caroline s Emergency Care in the Streets Student Workbook

Nancy Caroline's Emergency Care in the Streets, Seventh Edition is the next step in the evolution of the premier paramedic education program. This legendary paramedic textbook was first developed by Dr. Nancy Caroline in the early 1970s and transformed paramedic education. Today, the American Academy of Orthopaedic Surgeons is proud to continue this legacy and set the new gold standard for the paramedics of tomorrow. The Seventh Edition reflects the collective experience of its top-flight author team and decades of street wisdom. This fully updated edition covers every competency statement of the National EMS Education Standards for paramedics with clarity and precision in a concise format that ensures student comprehension and encourages critical thinking. This edition emphasizes the ideal that becoming a paramedic is a continual pursuit of growth and excellence throughout an entire career. Concepts of team leadership and professionalism are woven throughout the chapters, challenging students to become more compassionate, conscientious health care professionals as well as superior clinicians.

Microwave Journal

( EMT 1125 ) ter II treats the homogeneous unbounded electron plasma in uniform field ; microscopic ( Lorentzian ) and ... Lab . Series , Vol . 5 , p . 162 . 2 MEGAWAN PULSER Output 30 ky at 70 amp . Duty cycle .001 . Rep ratos 1 ...

Microwave Journal


Scientific and Technical Aerospace Reports

Volume 1 : Annex 5 to the WMO technical regulations - global aspects [ WMO - 544 - VOL - 1 ] 01 p0098 N81-10649 The ... 81-129 ] Validation of the guidelines for portable 20 p2730 N81-29143 meteorological instrumentation package .

Scientific and Technical Aerospace Reports

Lists citations with abstracts for aerospace related reports obtained from world wide sources and announces documents that have recently been entered into the NASA Scientific and Technical Information Database.

Nuclear Science Abstracts

GORDON MCKAY LAB . ... 4/71 , 25 : 40414 ( CONF - 710418( vol.1 ) ) Conference on magnet chydrodynamic electrical power generation ... Prog . rpt . on isolation of factor preventing x - ray induced leukemia , final , 6 / 1 / 64--5 ...

Nuclear Science Abstracts

NSA is a comprehensive collection of international nuclear science and technology literature for the period 1948 through 1976, pre-dating the prestigious INIS database, which began in 1970. NSA existed as a printed product (Volumes 1-33) initially, created by DOE's predecessor, the U.S. Atomic Energy Commission (AEC). NSA includes citations to scientific and technical reports from the AEC, the U.S. Energy Research and Development Administration and its contractors, plus other agencies and international organizations, universities, and industrial and research organizations. References to books, conference proceedings, papers, patents, dissertations, engineering drawings, and journal articles from worldwide sources are also included. Abstracts and full text are provided if available.

Electronics

Complete package with indicator system , Full target acquisition and automatic tracking . ... Lab . Series , Vol . 5 , D. 152 . 2 MEGAWATT PULSER Output 30 ky at 70 amp . Duty cycle .001 . Rep rates . 1 microseo 600 Dp9 , 1 or 2 msco ...

Electronics


Electronics Buyers Guide

Lab . Series , Vol . 5 , p . 152 . X band with plotting board . Complete . 2 MEGAWATT PULSER AN / GPG - 1 SKY Output 30 kv at 70 amp . Duty cycle .001 . ... Complete with high voltage power supply . plete package with indicator system .

Electronics Buyers  Guide


Over the counter drugs

1 ) . A number ( V331-34 ) , " Draft of Unpublished Data is of studies in humans also demonIncluded in OTC Volume ... with certain of Unpublished Data is Included in OTC Volume 040298 . laboratory tests , such as 5 - hydroxyin( 11 ) ...

Over the counter drugs


Selected Water Resources Abstracts

M. Stewart Ground Water GRWAAR . Vol . 26 , No. 2 , р 187191 , March - April 1988. 5 fig . 1 tab , 10 ref . Descriptors : * Saline water - fresh water interfaces , * Groundwater potential . * Data acquisition . * Mapping . * Islands .

Selected Water Resources Abstracts


Books in Print

Books in Print


The Role of ncRNAs in Solid Tumors Prognosis From Laboratory To Clinical Utility

The relationships between these targets' sets were analyzed and visualized by bioinformatic software TBtools and R package “UpSetR” (31, 32). Pan-Cancer Prognostic Value of Overlapping Genes In order to explore the prognostic of ...

The Role of ncRNAs in Solid Tumors Prognosis  From Laboratory To Clinical Utility


Hazardous Laboratory Chemicals Disposal Guide Third Edition

Wear breathing apparatus if necessary, eye protection, laboratory coat, and butyl rubber gloves. Cover spill with a 1:1:1 mixture by weight of sodium carbonate, clay cat litter (bentonite), and sand. Scoop into a container.

Hazardous Laboratory Chemicals Disposal Guide  Third Edition

A perennial bestseller, Hazardous Laboratory Chemicals Disposal Guide, Third Edition includes individual entries for over 300 compounds. The extensive list of references has been updated and includes entries for 15 pesticides commonly used in greenhouses. Emphasis is placed on disposal methods that turn hazardous waste material into non-toxic products. These methods fall into several categories, including acid/base neutralization, oxidation or reduction, and precipitation of toxic ions as insoluble solids. The text also provides data on hazardous reactions of chemicals, assisting laboratory managers in developing a plan of action for emergencies such as the spill of any of the chemicals listed.

Encyclopedia of Optimization

solving systems of nonlinear (and linear) equations; consult, e. g., [20] The volume [24] also covers a broad range of ... 1. Argonne National Lab (1993) MlNPACK-2 test problem collection. Argonne National Lab., Argonne, lL, ...

Encyclopedia of Optimization

The goal of the Encyclopedia of Optimization is to introduce the reader to a complete set of topics that show the spectrum of research, the richness of ideas, and the breadth of applications that has come from this field. The second edition builds on the success of the former edition with more than 150 completely new entries, designed to ensure that the reference addresses recent areas where optimization theories and techniques have advanced. Particularly heavy attention resulted in health science and transportation, with entries such as "Algorithms for Genomics", "Optimization and Radiotherapy Treatment Design", and "Crew Scheduling".

Advances in Heterogeneous Material Mechanics 2011

... the pressure increment to the volume increment, therefore K S (1) (1) n eff n dF dP n n (5) (6) (7) 12 12 e R dR R For two specific case (complete smooth and complete friction) of hydrostatic loading, ...

Advances in Heterogeneous Material Mechanics 2011

The third book in a series on heterogeneous materials, this volume offers integrated approaches to the measurement and modeling of materials using approaches from materials science, physics, mechanics, biology and other disciplines. The volume contains 289 chapters presenting original research on the connections among the nano- , micro-, and mesoscale mechanical properties and behaviors of many different types of engineered and natural heterogeneous materials. The book contains a wealth of never published multiscale data on materials loading behaviors, plasticity, creep, damage, fracture and failure. A separate section is devoted to the design and functionalization of materials using multiscale data and techniques