Free Radicals in Biology and Medicine

New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers.

Free Radicals in Biology and Medicine

Free Radicals in Biology and Medicine has become a classic text in the field of free radical and antioxidant research. Now in its fifth edition, the book has been comprehensively rewritten and updated whilst maintaining the clarity of its predecessors. Two new chapters discuss 'in vivo' and 'dietary' antioxidants, the first emphasising the role of peroxiredoxins and integrated defence mechanisms which allow useful roles for ROS, and the second containing new information on the role of fruits, vegetables, and vitamins in health and disease. This new edition also contains expanded coverage of the mechanisms of oxidative damage to lipids, DNA, and proteins (and the repair of such damage), and the roles played by reactive species in signal transduction, cell survival, death, human reproduction, defence mechanisms of animals and plants against pathogens, and other important biological events. The methodologies available to measure reactive species and oxidative damage (and their potential pitfalls) have been fully updated, as have the topics of phagocyte ROS production, NADPH oxidase enzymes, and toxicology. There is a detailed and critical evaluation of the role of free radicals and other reactive species in human diseases, especially cancer, cardiovascular, chronic inflammatory and neurodegenerative diseases. New aspects of ageing are discussed in the context of the free radical theory of ageing. This book is recommended as a comprehensive introduction to the field for students, educators, clinicians, and researchers. It will also be an invaluable companion to all those interested in the role of free radicals in the life and biomedical sciences.

Free Radicals in Biology and Medicine

Designed for biologists and clinicians who have little knowledge of chemistry, this text provides an understanding of the nature of free radicals.

Free Radicals in Biology and Medicine

Designed for biologists and clinicians who have little knowledge of chemistry, this text provides an understanding of the nature of free radicals. It explains what they are, how they are generated, how they react and gives the role of radical reactions in several biological systems.

Oxygen Radicals in Biology and Medicine

This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla.

Oxygen Radicals in Biology and Medicine

This book is based on the papers presented at the "Fourth International Congress on Oxygen Radicals (4-ICOR)," held June 27 - July 3, 1987, at the University of California, La Jolla. The chapters deal with the phenomena associated with highly reactive oxygen species (hydroxy, peroxy, alkoxy, aroxy, and superoxide radicals, as well as singlet oxygen) and their peroxidation products (hydrogen peroxide, hydroperoxides, peroxides, and epoxides) as they relate to the fields of chemistry, food technology, nutrition, biology, pharmacology, and medicine. The kinetics, energetics, and mechanistic aspects of the reactions of these species and the interrelationship of oxygen radicals (or any other free radicals) and peroxidized products have been emphasized. Special attention is focused on the mechanisms of the generation of free radicals and peroxy products in biosystems and on the adverse effects of these radicals and products in humans. The topics span the continuum from the simple chemistry of model systems to the complex considerations of clinical medicine. The book also explores the mechanisms of agents that protect against free radicals and peroxy products in vitro and in vivo. These agents include antioxidants used in materials, food antioxidants, physiological antioxidants, and antioxienzymes (SOD, glutathione peroxidase, and catalases). The use of these inhibitors to prevent damage to organs being prepared for transplantation, thereby maintaining the quality of transplanted organs and/or extending their "shelf-life," also is examined.

Excited States and Free Radicals in Biology and Medicine

This text introduces the reader to this rapidly expanding field, one that lies at the borderlines of physics, chemistry, biology, pharmacology, and medicine.

Excited States and Free Radicals in Biology and Medicine

Excited states and free radicals are involved in the normal physiology of living systems, in pathological processes (including lipid peroxidation, inflammation, Parkinson's disease, cancer, and aging), in the mechanisms of drug action, and in the photochemotherapies such as the PUVA therapy for skin diseases and PDT for cancer. This text introduces the reader to this rapidly expanding field, one that lies at the borderlines of physics, chemistry, biology, pharmacology, and medicine. The authors explore in particular how time-resolved spectroscopic methods have found solutions at the molecular level to biological and medical problems. Topics include the nature of excited states and free radicals and the techniques for their study, activated oxygen species, DNA, proteins, carotenoids and photosynthetic reaction centers, photodermatology and melanogenesis, and aspects of cancer related to radio-, chemo-, and photodynamic therapy. Researchers and graduate students in photochemistry, photobiology, photomedicine, radiation chemistry and biology, and cancer therapies will find this book to be of very significant interest.

Free Radicals in Biology and Medicine

Whilst their production by phagocytic cells is, of course, essential for the eradication of invading pathogens, and the capacity of selected chemotherapeutic agents to generate such species in specific `target' cells is well known in cancer ...

Free Radicals in Biology and Medicine

"Oxidative stress and inflammatory cell death / tissue damage have been implicated in a wide array of human diseases, including cancer, neurodegenerative diseases, diabetes, inflammatory joint diseases,; cardiovascular dysfunctions as well as ageing. Oxidative stress mediates the activation of transcription factors such as NF?B that, in turn, induce the transcription of certain genes promoting cytokine production. Release of these cytokines results in the enhancement of inflammatory responses and activation of endothelial cells in distant organs. The inflammatory cascade is then triggered by the induction of adhesion molecules and the generation of cytokines and other inflammatory mediators. Given that reactive oxygen and nitrogen species (ROS and RNS respectively) generated by infiltrated neutrophils into distant organs act directly as noxious agents reacting with molecular components, thereby enhancing inflammatory processes and therefore influencing cell viability, ROS and RNS have become potential therapeutic targets for prophylactic biofactors. Whilst their production by phagocytic cells is, of course, essential for the eradication of invading pathogens, and the capacity of selected chemotherapeutic agents to generate such species in specific `target' cells is well known in cancer research, the novel therapeutic actions and potential mechanisms of action of ozone as a microbicidal agent in clinical dentistry are now being advocated. The focus of this publication prominently encompasses the pivotal roles of ROS and RNS in the pathogenesis of many clinical conditions (together with their involvement in the ageing process of lower (yeast) cells, and higher organisms including plants), and discusses the potential applications of dietary-derived antioxidants to interfere with the biomolecular mechanisms of these processes and hence offer realistic therapeutic or prophylactic potentials."

Free Radicals in Biology and Medicine

OH Hydroxyalkylperoxyl radicals formed from alcohols such as ethanol ,
methanol , and mannitol , or from some carbohydrates ( e.g. glucose ) can
decompose in this way . If metal ions are present , 0 , can give more OH ' by a
catalysed Haber ...

Free Radicals in Biology and Medicine

The importance of radical reactions in radiation damage, food preservation, combustion, and in the rubber and paint industries has been known for many years. Such reactions have recently become of great interest to biologists and clinicians as their significance in normal body chemistry and inthe mode of action of many toxins has been recognized. The discoveries of hypoxic cell sensitizers that potentiate radiation-induced radical damage to cancerous tumours, of the enzyme superoxide dismutase, and of the mechanism of action of such toxins as paraquat and carbon tetrachloride providemajor examples of this importance.The explosive growth of interest in free radicals in recent years has necessitated the production of this second edition. The text has been extensively rewritten and the authors have taken the opportunity to update references to include recent research in this area. Aimed primarily at biologistsand clinicians, the book assumes virtually no knowledge of chemistry, although later chapters will also be of interest to free-radical chemists.

Free Radicals and Iron

This concise monograph describes a variety of important reactions of iron in biological free-radical reactions.

Free Radicals and Iron

This concise monograph describes a variety of important reactions of iron in biological free-radical reactions. It presents both a chemical and a biochemical perspective of the topic, but at the same time unifies ideas where possible. Iron plays a key role in biological life processes, as acatalayst enabling us to use oxygen to generate the heat and chemical energy that drives life. When iron is not properly controlled within the body it can cause damage by making free radicals. The authors present a chemical and biomedical perspective of how reactions of iron complexes and freeradicals may contribute to human health and disease, especially in reactions of oxygen and hydrogen peroxide.

Free Radicals in Biology and Environment

Free Radicals in Biology and Environment draws together two important areas of free radical chemistry, using as a bridge the fundamental physical chemistry of free radicals (spectroscopic detection of free radicals, evaluation of absolute ...

Free Radicals in Biology and Environment

Our understanding of the quantitative aspects of free radical chemistry and the involvement of radicals in such areas as biology, medicine, the environment, etc., has developed spectacularly over recent years, yet the various topics are commonly discussed separately, in specific meetings and specialised publications. Free Radicals in Biology and Environment draws together two important areas of free radical chemistry, using as a bridge the fundamental physical chemistry of free radicals (spectroscopic detection of free radicals, evaluation of absolute rate constants, elucidation of mechanisms of free radical reactions and catalysis, photochemical and radiation processes, etc.). The most relevant topics covered are the EPR detection of radicals in biochemical systems and in pollutant formation and degradation, oxidation processes in biology and in the troposphere, radiation and induced damage, and atmospheric pollutants arising from incomplete combustion. Also covered are the chemistry and biochemistry of nitric oxide and peroxynitrite, the chemistry and biochemistry of DNA radicals, the role of radicals in myeloperoxidase, lignineperoxidase, radicals and cardiovascular injury, radiation and the fragmentation of cells and tissues.

Free Radicals from Basic Science to Medicine

Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.

Free Radicals  from Basic Science to Medicine

Free radical-mediated reactions have been well known in chemistry and physical chemistry for many years. Applying this knowledge to living organisms, biochemists have shown that reactive free radicals are formed at many intracellular sites during normal metabolism, and they have started to suggest possible roles in various pathological processes and conditions, for example in radiation damage, in the metabolism of xenobiotics, in carcinogenesis and in metabolic disorders. At present, a large and relevant mass of experimental evidence supports the view that reactive free radicals are involved in the pathogenesis of several diseases and syndromes. This literature has captured the attention and interest of people involved in the biomedical field. Exciting developments in radical research are probable in the near future, establishing a greater interaction between basic science research and medicine. While the task of defining the involvement of free radicals in human pathology is difficult, it is nonetheless extremely important that such interaction be fulfilled as soon as possible. These were the considerations motivating us during the organization of the VI Biennial Meeting of the International Society for Free Radical Research held in Torino, Italy, in June 1992, and also during the preparation of this book. Experts in the various aspects of free radical research were invited to participate in the Torino Meeting and to contribute chapters for this volume.

Free Radical Medicine and Biology

This book highlights various issues of free radical biology from the perspective of antioxidant defense mechanisms.

Free Radical Medicine and Biology

Although free radicals perform some useful immune functions, they can also damage healthy cells through a process called oxidation. Antioxidants reduce the effect of free radicals by binding together with these harmful molecules, decreasing their destructive power. This book highlights various issues of free radical biology from the perspective of antioxidant defense mechanisms. It also provides useful information on gene modulation, radiation-generated reactive oxygen species-induced apoptosis in cancer, and environmental aspects associated with free radicals’ exposure on living systems.

Free Radicals in Biology

Preface to Volume III This volume contains chapters that cover topics ranging
from radiation chemistry to biochemistry , biology , and medicine . It is the aim of
this multivolume treatise to review the diverse topics in free radical biology and ...

Free Radicals in Biology

Free Radicals in Biology V3.