Giacomini P, Aguzzi A, Ferrone S (1986) Differential susceptibility to modulation by recombinant immune interferon of HLA-DR and -DQ antigens synthesized by melanoma COLO 38 cells. Hybridoma 5, 277. Giacomini P, Gambari R, Barbieri R et ...
Author: Roumen G. Tsanev
Publisher: CRC Press
Now for the first time, one comprehensive book summarizes and analyzes the numerous scientific papers and reviews covering selected aspects of the structure, biological activities, and clinical effects of immune interferon, also known as interferon-gamma(IFN-gamma). Immune Interferon: Properties and Clinical Applications is essential reading for an
Characterization of receptor for immune interferon in 1937 cells with 32P - labeled human recombinant immune interferon . J. Biol . Chem . 260 , 8514-8519 . 8. PESTKA , S. , LANGER , J.A. , ZOON , K.C. , and SAMUEL , E.C. ( 1987 ) .
Friedman , R. and Cooper , H. , Stimulation of interferon production in human lymphocytes by mitogens , Proc . Soc . Exp . Biol . Med . , 125 , 901 , 1967 . 67. Green , J. A. , Cooperband , S. R. , and Kibrick , S. , Immune specific ...
Author: Stanley Cohen
Publisher: CRC Press
This book provides a broad overview of all aspects of modern lymphokine research. It begins with the ways in which lymphokines play a role in the activation of the immune response and concludes with their participation in various facets of host defense. It devotes special attention to structure, mechanism of action, and range application. In addition, this fascinating work also shows how lymphokines are involved in other physiologic responses, such as reparative reactions involving fibrosis and angiogenesis. This is an excellent resource for students and investigators in the biomedical sciences, as well as clinicians who require up-to-date information about our current understanding of immune processes.
Simonsen, C.C., Shepard, H. M., Gray, P. W., Leung, D. W., Pennica, D., Yelverton, E., Derynck, R., Sherwood, P.J., Levinson, A. D., and Goeddel, D. V., Plasmid-directed synthesis of human immune interferon in E. coli and monkey cells, ...
Author: Richard C. Niemtzow
Publisher: CRC Press
First Published in 1979, this book offers a full, comprehensive guide into the potential application of immune and tumor cells. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.
However, the primary sequence of immune interferon (IFI) consists of l46 amino acids (Fig. 18). Neither the fibroblast (Fig. 17) nor the leukocyte (Fig. 19) interferon genes contain any intervening sequence.
Author: Takeda Kagaku Shinkō Zaidan
Humoral Factors in Host Defense contains the proceedings of the First Takeda Science Foundation Symposium on Bioscience, held on October 28-30, 1982, in Kyoto, Japan. The symposium focused on the humoral factors regulating immune responses, with emphasis on T cell-derived immunoregulatory molecules; molecular mechanisms of interferons; factors involved in differentiation and activation of immunocytes; and the use of the molecular genetics approach to host defense factors. Organized into four parts encompassing 22 chapters, this volume begins with an overview of interleukin-2 and T cell-replac ...
Enhancement by interferon of the expression of surface antigens on murine leulemia L1210 cells. Proc Natl Acad Sci USA 70:2785–2788. Lindahl P, Gresser I, Leary P, and Tovey M. (1976). Enhanced expression of histocompatibility antigens ...
Author: Smith Kendall A
Publisher: World Scientific
This book covers a scientific history of the discoveries in immunology of the past 60-years, i.e. what was discovered, who made the advances and how they accomplished them, and why others did not.All molecular advances occurred in the last 60 years, and no one has described them.
... antigen specific immune response Interleukin-3 (IL-3)/hematopoietic growth factor T cells 133 Proliferation and ... antibacterial and anticancer activity Interferon Y (IFN-Y)/immune interferon T lymphocytes 146 Antiviral and ...
Author: Johann Schaller
Publisher: John Wiley & Sons
Human plasma contains the most comprehensive version of the human proteome. The complexity of the ‘plasma proteome’ is quickly understood when one considers all the various forms of blood plasma proteins present in plasma: precursor and mature forms, splice variants, degradation products and of course all combinations of posttranslational modifications. Human Blood Plasma Proteins gives an overview of the proteins found in human blood plasma, with special emphasis on their structure and function and relationship to pathological states and disease. Topics covered include: Introduction to blood components and blood plasma proteins Blood plasma protein domains, motifs and repeats Blood plasma protein families and posttranslational modifications Blood coagulation and fibrinolysis The complement system The immune system Enzymes Inhibitors Lipoproteins Hormones Cytokines and growth factors Transport and storage The information of each protein discussed in this book in some detail is summarised at the end of each chapter in a Data Sheet, where one can find the most important data of each protein at one glance. Full cross-referencing to protein databases is given and many of the proteins discussed are accompanied by their 3D structure. Human Blood Plasma Proteins is an essential atlas of this proteome for anyone working in biochemistry, protein chemistry and proteomics, structural biology, and medicine.
The Immune Response in Infectious and Inflammatory Disease Anthony DeFranco, Richard M. Locksley, Miranda Robertson. Innate Defense Against Viruses: Interferon 3-16 phagocytosis or macropinocytosis. Tissue macrophages, immature ...
Author: Anthony DeFranco
Publisher: New Science Press
Immunity: The Immune Response to Infectious and Inflammatory Disease presents an engaging insight into one of the most intricate yet conceptually challenging biological systems. With a unique emphasis on the immune response to infection, it builds up a complete picture of the immune system as a dynamic interface with the outside world.
Takaoka A, Yanai H. Interferon signalling network in innate defence. Cell Microbiol 2006; 8:907-922. 9. van Wamel WJ, Rooijakkers SH, Ruyken M et al. The innate immune modulators staphylococcal complement inhibitor and chemotaxis ...
Author: Alexander Sigalov
Publisher: Springer Science & Business Media
This book shows how the structural similarity of MIRRs determines the general principles underlying MIRR-mediated transmembrane signaling mechanisms. In so doing, it provides the basis for existing and future therapeutic strategies targeting MIRRs.
There is growing evidence that overt innate-immune interferon signaling plays a critical role in the development of other forms of autoimmune conditions (45). Taken together, this suggests that RIG-I and MDA5 may differ significantly in ...
15 Trinchieri G, Perussia B: Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol Today 1985;6:131–136. 16 Farrar MA, Schreiber RD: The molecular cell biology of interferon- and its receptor.
Author: Jerry Y. Niederkorn
Publisher: Karger Medical and Scientific Publishers
In memory of J. Wayne Streilein, the pioneer in ocular immunology The second edition of Immune Response and the Eye' highlights recent insights into the dangerous compromise' between the immune system and the eye, which protects the eye against pathogens while limiting inflammation and immune-mediated injury to ocular tissues with little or no regenerative potential. It discusses the broad spectrum of physiological, immunological, anatomical, and biochemical adaptations that conspire to closely regulate the tone and tenor of immune responses in the eye. This volume further describes immune-mediated diseases that occur when the compromise between the immune system and the eye is breached. This breakdown in immune privilege threatens the vision of millions each year. Finally, recent advances in ocular immunology are presented, which offer potential therapeutic applications in corneal and retinal transplantation and in the management of blinding autoimmune diseases of the eye. Eye researchers, ophthalmologists and immunologists will appreciate the state-of-the-art and authoritative information presented in Immune Response and the Eye'
24 Trinchieri G, Perussia B: Immune interferon: A pleiotropic lymphokine with multiple effects. Immunol Today 1985;6:131–136. 25 Farrar MA, Schreiber RD: The molecular cell biology of interferon- ...
Author: J. Wayne Streilein
Publisher: Karger Medical and Scientific Publishers
In this book, the physiologic bases of ocular immune privilege and the distinctive systemic immune responses elicited by eye derived antigens are described. Several chapters discuss the pathogeneses of these disorders which arise from infections, autoimmunity, and neoplasms. Finally, chapters devoted to corneal and retinal transplantation describe attempts to exploit ocular immune privilege to promote graft survival and thereby cure blindness. Ophthalmologists, both clinicians and physician scientists, general and tumor immunologists, transplantation biologists and anyone seeking to understand the immunopathogenic diseases that threaten vision will appreciate the information presented in this book.
Cloning and expression of flatfish (Paralichthys olivaceus) interferon cDNA. Biochim. Biophys. Acta 1174, 182–186. ... Immune interferon: a pleiotropic lymphokine with multiple effects. Immunol. Today 6, 131–136.
Publisher: Academic Press
This book comprehensively reviews the immunology of fish--their health, interactions between them and their pathogens, and the impact of both endogenous and environmental changes on these interactions. Leading authorities provide an essential foundation for the understanding of fish immunology and fish health. As fish are increasingly used as model systems for vertebrate immune systems, The Fish Immune System will be a crucial reference. The only comprehensive, single-volume reference on the fish immune system Contributions from an international team of experts Useful to researchers interested in fish health as well as professionals managing fish hatcheries, aquariums, and other facilities that must maintain healthy fish
64. cyte natural killing by mixtures of alpha or beta interferon with recombinant gamma interferon. Infect Immun 40:35–38 (1983). ... Braun W and Levy HB: Interferon preparations as modifiers of immune responses.
Author: Franco M. Muggia
Publisher: Springer Science & Business Media
Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general oncology textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often preliminary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfor tunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by dividing the oncology literature into specific subdivisions such as lung can cer, genitourinary cancer, pediatric oncology, etc. Second, by asking emi nent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.
Immune memory and exhaustion: clinically relevant lessons from the LCMV model. ... Immunity. 2009;31(3):491–501. Hooks JJ, Moutsopoulos HM, Geis SA, et al. Immune interferon in the circulation of patients with autoimmune disease.
Author: Daniel Wallace
Publisher: Elsevier Health Sciences
For more than 50 years, Dubois’ Lupus Erythematosus and Related Syndromes has been recognized internationally as the go-to clinical reference on lupus and other connective tissue diseases. From basic scientific principles to practical points of clinical management, the updated 9th Edition provides extensive, authoritative coverage of systemic lupus erythematosus (SLE) and its related diseases in a logical, clearly written, user-friendly manner. It’s an ideal resource for rheumatologists and internal medicine practitioners who need a comprehensive clinical reference on all aspects of SLE, connective tissue diseases, and the antiphospholipid syndromes. Provides complete clinical coverage of every aspect of cutaneous and systemic lupus erythematosus, including definitions, pathogenesis, autoantibodies, clinical and laboratory features, management, prognosis, and patient education. Contains an up-to-date overview of significant advances in cellular, molecular, and genetic technologies, including genetic advancements in identifying at-risk patients. Offers an increased focus on the clinical management of related disorders such as Sjogren’s syndrome, scleroderma, polymyositis, and antiphospholipid syndrome (APS). Presents the knowledge and expertise of more international contributors to provide new global perspectives on manifestations, diagnosis, and treatment. Features a vibrant, full-color format, with graphs, algorithms, differential diagnosis comparisons, and more schematic diagrams throughout.
A FEW WORDS ABOUT NOMENCLATURE The standard abbreviation for interferon is IFN, the symbol used throughout the book. Based on molecular structure, ... IFN-y, which is acid-labile is sometimes referred to as immune IFN or type II IFN.
Author: E. M. DeMaeyer
This text provides a presentation of the state-of-knowledge of interferons (IFNs) providing a synthetic overview of the role and significance of IFNs in health and disease. Treatment is placed in a broad biological context including much up-to-date background information on the different systems (eg oncogenes or T cell function) that are under the influence of IFNs. This approach makes the book accessible to those not directly involved in IFN research. Coverage also includes other cytokines, such as tumor necrosis factor alpha and beta, and the various interleukins.
Irina V. Nesterova, Svetlana V. Kovaleva, Valentina V. Malinovskaya, Galina A. Chudilova and Tatyana V. Rusinova Abstract This chapter reviews various interferon (IFN) system disturbances—inter- feronopathies.
Author: Shailendra K. Saxena
Publisher: BoD – Books on Demand
The book focuses on various aspects and properties of innate immunity, whose deep understanding is integral for safeguarding the human race from further loss of resources and economies due to innate immune response-mediated diseases. Throughout this book, we examine the individual mechanisms by which the innate immune response acts to protect the host from pathogenic infectious agents and other non-communicable diseases. Written by experts in the field, the volume discusses the significance of macrophages in infectious disease, tumor metabolism, and muscular disorders. Chapters cover such topics as the fate of differentiated macrophages and the molecular pathways that are important for the pathologic role of macrophages.