Immunology and Psychiatry

... Biological Psychiatry (WFSBP), since 2006 he was chair of the section “Immunology in Psychiatry” of the World Psychiatric Association (WPA). He won several honours and scientific awards including the Emil-Kraepelin Research Award.

Immunology and Psychiatry

Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.​

Psychiatry Psychoimmunology and Viruses

The contributions in this book deal with basic research in psychoneuroimmunology, dysfunctions of the immune system in psychiatric disorders and the possible role of viruses in psychoneuroimmunological processes.

Psychiatry  Psychoimmunology  and Viruses

The contributions in this book deal with basic research in psychoneuroimmunology, dysfunctions of the immune system in psychiatric disorders and the possible role of viruses in psychoneuroimmunological processes. Growing knowledge about the reciprocal relationship between psychic processes and the immune system implicates more interest of clinical psychiatrists in this field because immunological dysfunction is found in depression and schizophrenia, but also in other psychiatric syndromes like anxiety disorders. The authors of the chapters, all active researchers in the field, describe the results of their scientific work and the actual state of the art. The interdisciplinary character of this book is outlined by the broad international and disciplinary range of the authors which represent a spectrum from basic scientists like pharmacologists and immunologists up to clinical psychiatrists and neurologists. New findings regarding the role of the immune system in sleep and in headache are discussed. Special emphasis is laid on methodological pitfalls in immunological studies of psychiatric disorders. Perspectives for future therapeutical strategies are outlined.

Immunopsychiatry

This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the ...

Immunopsychiatry

In recent years, a dedicated effort has been made to understand the immune dysfunction that is associated with major psychiatric disorders. The expanding knowledge of the immune system as a major homeostatic system has been very helpful in indicating new potential biomarkers and therapeutic targets to reduce the burden of psychiatric disorders. Indeed, immune cells, their secreted molecules, and cell signalling events are highly promising. Yet, the literature on immunology of psychiatric disorders is still dispersed, and only a few attempts have been made to consolidate the current knowledge in this expanding area. This book assembles and presents the available data on the immune/inflammatory dysfunction in psychiatric disorders, indicating the potential of immune mechanisms as either biomarkers or therapeutic targets, as well as discussing the challenges ahead of incorporating this knowledge into clinical practice. An international team of senior experts in the field review all psychiatric disorders in order to provide an integrated, in-depth understanding of the role of immune changes in psychiatric diseases for mental health clinicians as well as for researchers in immunology, psychiatry, neurology, and pharmacology.

Immuno Psychiatry

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications.

Immuno Psychiatry

This book presents a thorough and critical review of current knowledge on the role of immunology in major psychiatric disorders and its potential applications. The opening chapters offer general information on the immune influence of the brain to provide readers with a better understanding of the end of immune privilege. The book then examines possible underlying mechanisms leading to psychiatric disorders, from early infections to pro-inflammatory markers, stress, and immune genetic background, linking etiology and psychiatry. The third section describes each disorder (ie autism, schizophrenia, bipolar disorder, depression...) with an overview of underlying immune dysfunctions. Lastly, the authors discuss the innovative immune-therapies that may result from the discovery of immune system biomarkers and their associated mechanisms. A better understanding of the role of the immune system in psychiatric disorders makes it possible to identify stratification biomarkers, to explain underlying mechanisms, and to develop innovative, efficient, targeted treatment strategies and management. As such, the book is of value to clinicians, mental health professionals, mental health researchers, immunologists, industry practitioners, and various stakeholders in the mental health field.

Immunology and Psychiatry

The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia ...

Immunology and Psychiatry

Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.​

Recent Advances in Psychiatry from Psycho Neuro Immunology Research Autoimmunencephalitis Autoimmune Encephalopathy Mild Encephalitis

published: 29 March 2019 doi:10.3389/fpsyt.2019.00169 Edited by: Merete Nordentoft, University of Copenhagen, Denmark Editorial: Recent Advances in Psychiatry From Psycho-Neuro-Immunology Research: Autoimmune Encephalitis, ...

Recent Advances in Psychiatry from Psycho Neuro Immunology Research  Autoimmunencephalitis  Autoimmune Encephalopathy  Mild Encephalitis

Growing evidence derived from cerebrospinal fluid (CSF), neuropathological, imaging, genetic, and epidemiological studies link neuroinflammation and immune dysregulation to a subset of individuals with a variety of severe mental disorders (SMDs), including affective and non-affective psychotic disorders. Further, the recent discoveries of neuronal surface antibodies (NSAs) in autoimmune encephalitis (AE) presenting with diverse neuropsychiatric disorders such as psychosis and cognitive decline, among many others, provides further support to the notion that CNS autoimmunity and neuroinflammation can contribute to the neurobiology of psychiatric disturbances. Further, these immune mechanisms may contribute to a subset of patients currently diagnosed as having treatment-resistant SMDs such as schizophrenia and major depressive disorder. Additionally, mounting data indicate that various infections can serve as an immunological trigger of aberrant immune responses, presumably by causing release of excess neural antigen, thereby giving rise to NSAs or aberrant immune cellular responses to give rise to primary or secondary psychiatric disorders such as schizophrenia and those associated with AE, respectively. Collectively, these findings support the “mild encephalitis” hypothesis of SMD. The significant overlap among AE-associated psychosis, systemic autoimmune disorder-associated psychosis, and psychotic disorders associated with pathological processes involving inflammation and immune dysregulation has also prompted some authors to adopt the term “autoimmune psychosis” (AP). This term reflects that this psychosis subtype is mechanistically linked to complex neuroimmune and inflammatory signalling abnormalities that can be responsive to early immunomodulatory treatment. It also suggests that a subset of AP might represent an incomplete or “forme fruste” subtype of AE presenting with dominant or pure psychiatric symptoms mimicking primary psychiatric illnesses. Because data indicate that delayed diagnosis and treatment may lead to permanent sequelae, early recognition of AP utilizing neurodiagnostic workup (e.g., CSF analysis, neuroimaging, and EEG) and its early treatment with appropriate immunotherapy are paramount to a meaningful recovery. This eBook will provide an overview of the current knowledge and research areas from epidemiology, risk factors and diagnosis to the management of these conditions, in this rapidly emerging field, helping to bridge the gaps in knowledge that currently exist in the disciplines of Psychiatry, Neurology, and Neuroimmunology.

Textbook of Immunopsychiatry

This book provides the first comprehensive overview of recent, inter-disciplinary research linking disordered function of the immune system to the brain and mental illness.

Textbook of Immunopsychiatry

The rapidly growing field of immunopsychiatry combines expertise and insights from immunology, psychiatry and neuroscience to understand the role of inflammation and other immune processes in causing and treating mental illness. This represents a major shift in mental health science, traditionally focused on psychological and neuronal mechanisms of depression, psychosis and dementia. This book provides the first comprehensive overview of recent, inter-disciplinary research linking disordered function of the immune system to the brain and mental illness. It offers a broad and deep perspective on the implications of immune system involvement in psychiatric disorders, including a balanced focus on basic science and clinical applications. Chapters cover the scientific evidence linking immune processes to major mental illnesses such as schizophrenia, depression, anxiety and dementia. An invaluable guide for graduate students, doctors in training, scientific researchers and others interested in the link between the immune system and mental health.

Oxford Textbook of Neuropsychiatry

They indicate that immunology and mental illness are fundamentally intertwined, opening exciting new avenues for future immunotherapies tackling psychiatric disease. Here we review basic immune mechanisms, specifically highlighting ...

Oxford Textbook of Neuropsychiatry

New from Oxford Textbooks in Psychiatry, the Oxford Textbook of Neuropsychiatry bridges the gap between general psychiatric textbooks and reference texts in neuropsychiatry. Divided into four sections, it covers core knowledge and skills for practice in all psychiatric disciplines, with key information for training in neuropsychiatry.

Current Update in Psychoimmunology

This book tries to close the gap between immunological findings on the one hand, psychological, psychopathological, electrophysiological and neuroimaging aspetcs on the other.

Current Update in Psychoimmunology

This book tries to close the gap between immunological findings on the one hand, psychological, psychopathological, electrophysiological and neuroimaging aspetcs on the other. It deals with the issue of "cause and effect” (of immunological alternatives) in different organic and/or mental disorders, and emphasizes the necessity of considering a variety of treatment strategies. There are dynamic interactions and several important similarities between the immune system and the central nervous system, which help to lay the rational basis for "psychoimmunology”. Both systems have the capacity for memory and both play vital roles in adaptation and defence. Furthermore, in each system pathological changes can occur in the event of inappropriate responses to internal or external stimuli, leading to psychiatric as well as organic illnesses and autoimmune diseases could also arise as a consequence of dysfunction respectively maladaptation. "... this book is a good way to approach the field of psychoimmunology, and shows that scientists are very active in this domain ...” Acta Neurologica Belgica.

National Research Funding Levels

Gelboin H V ( Biochemistry ) Gilden R V ( Immunology ) Herberman R B ( Oncology ) Huebner R J ( Oncology ) Johnson ... Ryan K J ( Endocrinology ) Schildkraut J J ( Psychiatry ) Schur P H ( Immunology ) Smith T W ( Cardiology ) Soeldner ...

National Research Funding Levels


Psychoneuroimmunology Stress and Infection

Changes over time in immunological measures , Arch . Gen. Psychiatry , 47,729 , 1990 . 63. ... A new era of immunology , of psychosomatic medicine , and of neuroscience , Brain Behav . Immun . , 7,352 , 1993 . 66.

Psychoneuroimmunology  Stress  and Infection

Psychoneuroimmunology is the emerging science devoted to studying the two-way relationship between the nervous and immune systems. Psychoneuroimmunology, Stress, and Infection highlights the latest information concerning microbial infections in both man and animals as related to stress and especially stress hormones. The volume focuses on psychoneuroimmunology as it impacts the immune system in general and also the relationship between neurological events which influence susceptibility and/or resistance to infectious agents such as bacteria, fungi and viruses, as well as parasites. Prominent researchers describe the involvement of the hypothalamus-pituitary-adrenal (HPA) axis on immunity as a function of the nervous system. The text discusses hormones such as prolactin and growth hormone and steroid induced susceptibility to infection and neuropeptides, including vasoactive intestinal peptide, and substance P. The effects of catacholamines on immunity and susceptibility to infection are also covered. This reference also details the involvement of immune cells in the synthesis of neuropeptides, including hormones and endorphins, their effect on the brain as well as the effects of interleukins and tumor necrosis factor on the central nervous system. The book concludes with an interesting look at the relationship between aging, psychoneuroimmunology, and infection. Although there is much new knowledge concerning the nature and mechanism of immune responses, including the mediators involved, Psychoneuroimmunology, Stress, and Infection also presents important discussions and reviews that are long overdue and provide a major contribution to the area of biomedical knowledge in general and psychoneuroimmunology in particular.

National Health Statistics Reports

Addiction medicine , addiction psychiatry , aerospace medicine , allergy , allergy & immunology , cardiovascular disease , child and adolescent psychiatry , child neurology , clinical and laboratory dermatological immunology , clinical ...

National Health Statistics Reports


Neuroinflammation Gut Brain Axis and Immunity in Neuropsychiatric Disorders

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders.

Neuroinflammation  Gut Brain Axis and Immunity in Neuropsychiatric Disorders

This book reviews the relationship between cytokines, glia, and neurons in the pathophysiology of neuropsychiatric disorders and examines the mechanisms of action of the drugs used for the treatment of these disorders. Increasing evidence has suggested that glia perform important roles in various brain functions, but much remains to be learned about these crucial cells and their interplay with neurons. In addition, a better understanding of the interaction between inflammatory mediators, such as cytokines, and the activated immune response will be of critical importance for the development of new therapeutic strategies. These key areas are the focus of this book, which documents the latest research findings in the field. Evidence is provided for the role of inflammation-induced toxic metabolites from the tryptophan pathway in a wide range of neuropsychiatric disorders, including depression, schizophrenia, and Alzheimer's disease. In presenting state of the art knowledge on the interactions between cytokines, glia, and neurons, the book will help to pave the way for the development of novel targets for the prevention and treatment of neuropsychiatric disorders.

Psychiatry and Biological Factors

The main purpose of the volume Psychiatry and Biological Factors is to provide a comprehensive, state-of-the-art overview of the current research linked essentially to virus infections, immunity functions, and mental diseases.

Psychiatry and Biological Factors

The main purpose of the volume Psychiatry and Biological Factors is to provide a comprehensive, state-of-the-art overview of the current research linked essentially to virus infections, immunity functions, and mental diseases. In recent years substantial advances have been registered in the physiopathol ogy of mental and neurological disorders. As a result, partial control of certain psychoses, anxiety syndromes, epilepsy, and Parkinson's disease is now possible. However, despite progress in biomedical research, numerous mental and neuro logical disorders afflict up to 15% of all individuals and little is known about the causes, prevention, and treatment of these diseases. Several epidemiological investigations demonstrated a high prevalence of functional psychoses and organic mental disorders, and recent data show that biological components appear as a major etiologic factor. In this respect it could be stressed that viral and immunologic hypotheses should be investigated seriously and systematically in relation to the mechanisms of several mental and neurologi cal diseases. Neuropsychiatric consequences of AIDS related to human immunodeficiency virus infection are now well documented. A variety of behavioral. symptoms and psychiatric syndromes with paranoid features are frequent concomitants of AIDS.

Immunological Alterations in Psychiatric Diseases

This book provides a concise overview of our present knowledge on the immunological aspects of psychiatric diseases, in particular schizophrenia, drug addiction and Alzheimer's disease.

Immunological Alterations in Psychiatric Diseases

During the past three decades psychiatric research has made use of the expertise and techniques of many medical disciplines, among them neuroendocrinology, immunology, virology, genetics, and molecular biology. This book provides a concise overview of our present knowledge on the immunological aspects of psychiatric diseases, in particular schizophrenia, drug addiction and Alzheimer's disease. In addition, fundamental questions concerning the bi-directional interactions between the central nervous system and the immune system are discussed and the role of viruses and infectious processes closely examined. As such, this book offers a unique presentation of the state of the art in psychoimmunology and, at the same time, shows many important challenges for future research into the field of intersystemic interactions and their impact on the etiology and pathogenesis of psychiatric diseases. Psychiatrists and neurologists will gain a better understanding of the biological basis of psychiatric diseases while immunologists, neuroimmunologists, neurobiologists, neuroendocrinologists and virologists will find it a valuable source of new information on psychoimmunology research.

Fundamentals of Psychoneuroimmunology

Journal of Immunology 159 : 2994- 2999 . Muller , N. and Ackeneheil , M. ( 1995 ) The immune system and schizophrenia . In : Leonard , B. and Miller , C. ( Eds ) Stress , the Immune System and Psychiatry , pp . 137- 164.

Fundamentals of Psychoneuroimmunology

Fundamentals of Psychoneuroimmunology Cai Song University of British Columbia, Vancouver, Canada, and Brian E. Leonard National University of Ireland, Galway, Ireland The long-held concept that the nervous, endocrine and immune systems are separate entities has given way to a new understanding of human biology. Psychoneuroimmunology addresses the realisation that the neural, immune, and endocrine systems are inextricably linked and that the effects of each affect all-the systems work together as a complicated set of triggers and balances, an intertwining of the physiological and emotional states. Beginning with the fundamentals of immune and neuroendocrine function, Fundamentals of Psychoneuroimmunology explores the complexities of behavioural assessment, the basic types of immunity, the importance of immune cell redistribution in the response to challenges such as infection and stress, and the multifaceted roles of nerves, hormones and cytokines. This text provides a sound introduction to the field and also serves as a valuable reference to those more familiar with the subject. Fundamentals of Psychoneuroimmunology: * Is the first book to cover this rapidly growing speciality comprehensively * Provides a sound biological basis to the discipline * Covers topics from the biology of immune and neuroendocrine function to the future of psychoneuroimmunology This volume, by the author of the acclaimed Fundamentals of Psychopharmacology, will be an essential reference for psychiatrists, neurologists, neuroimmunologists, neuroendocrinologists and psychologists, and will, it is hoped, stimulate further exploration into this exciting area of research.

Research Training in Psychiatry Residency

First, we reviewed the Accreditation Council for Graduate Medical Education (ACGME) requirements for different specialties, including psychiatry, neurology, internal medicine, and allergy and immunology, to determine key similarities ...

Research Training in Psychiatry Residency

The number of psychiatric researchers does not seem to be keeping pace with the needs and opportunities that exist in brain and behavioral medicine. An Institute of Medicine committee conducted a broad review of the state of patient-oriented research training in the context of the psychiatry residency and considered the obstacles to such training and strategies for overcoming those obstacles. Careful consideration was given to the demands of clinical training. The committee concluded that barriers to research training span three categories: regulatory, institutional, and personal factors. Recommendations to address these issues are presented in the committee's report, including calling for research literacy requirements and research training curricula tailored to psychiatry residency programs of various sizes. The roles of senior investigators and departmental leadership are emphasized in the report, as is the importance of longitudinal training (e.g., from medical school through residency and fellowship). As there appears to be great interest among numerous stakeholders and a need for better tracking data, an overarching recommendation calls for the establishment of a national body to coordinate and evaluate the progress of research training in psychiatry.

Chronic Diseases

The Iowa Record-Linkage Study, 1: Suicides and accidental deaths among psychiatric patients. Archives of General Psychiatry, 42, 58—66. Black, D. W., Warrack, G., & Winokur, ... Journal of Allergy and Clinical Immunology, 65, 263-268.

Chronic Diseases

Although considerable progress has been made in the understanding and treatment of a range of medical disorders, it had recently been pointed out that 85 percent of the population will be stricken by chronic disorders which may be accompanied by many years of suffering. This volume deals with issues of both cure and risk in chronic illnesses which are among the group of disorders associated with the leading causes of death in the United States at this time -- Alzheimer's disease, AIDS, and cancer. A consideration of the role of brain and behavior in relation to the cure and prevention of these disorders is the central focus of the various chapters in this book. Several chapters discuss the neuropsychological aspects of chronic illnesses including the underlying pathophysiology of changes in the brain which may be associated with both behavioral and physical signs and symptoms in these disorders. Considerable evidence suggests that a range of psychosocial or behavioral factors, such as stressful life events and depression, are associated with increased morbidity or mortality. Complex neurobiological pathways involving the brain, neurotransmitter, and neuroendocrine systems have been implicated. Other chapters consider some of the links among brain, behavior and chronic illnesses, as well as psychological factors such as coping and depression in relation to chronic disorders. The three leading risk factors known to be associated with both chronic illnesses and death -- diet, tobacco, and alcohol -- are all related to behavioral choices. Sexual behavior can be added to the list in terms of HIV infection and acquired immunodeficiency disease (AIDS). Several chapters deal specifically with a consideration of sexual behavior and HIV infection which clearly highlight the need for scientific knowledge in human sexuality if effective long term preventive measures are to be developed while waiting for a vaccine or cure. The search for cures must continue to have the highest priority in the scientific and clinical struggle against disease. Nonetheless, the value of psychosocial interventions on the quality of life and mental states of seriously ill persons should not be underestimated.