Neuronal Oscillations of Wakefulness and Sleep

The purpose of this work is to review recent findings highlighting the mechanisms and functions of the neuronal oscillations that structure brain activity across the sleep-wake cycle.

Neuronal Oscillations of Wakefulness and Sleep

The purpose of this work is to review recent findings highlighting the mechanisms and functions of the neuronal oscillations that structure brain activity across the sleep-wake cycle. An increasing number of studies conducted in humans and animals, and using a variety of techniques ranging from intracellular recording to functional neuroimaging, has provided important insight into the mechanisms and functional properties of these brain rhythms. Studies of these rhythms are fundamental not only for basic neuroscience, but also for clinical neuroscience. At the basic science level, neuronal oscillations shape the interactions between different areas of the brain and profoundly impact neural responses to the environment, thereby mediating the processing of information in the brain. At the clinical level, brain oscillations are affected in numerous neurological conditions and might provide useful biomarkers that inform about patients’ evolution and vulnerability. During sleep, these brain rhythms could provide functional support to internal states that govern the basic maintenance of local circuit and systemic interactions. During wake, the rhythmicity of cortical and subcortical circuits have been linked with sensory processing, cognitive operations, and preparation for action. This book will attempt to link together these sleep and wake functional roles at the level of neuroimaging and electroencephalographic measures, local field potentials, and even at the cellular level. ​

Handbook of Sleep Research

Theta waves in children's waking electroencephalogram resemble local aspects of sleep during wakefulness. Scientific Reports, 7, 11187. Feinberg, I. (1982).

Handbook of Sleep Research

Handbook of Sleep Research, Volume 30, provides a comprehensive review of the current status of the neuroscience of sleep research. It begins with an overview of the neural, hormonal and genetic mechanisms of sleep and wake regulation before outlining the various proposed functions of sleep and the role it plays in plasticity, and in learning and memory. Finally, the book discusses disorders of sleep and waking, covering both lifestyle factors that cause disrupted sleep and psychiatric and neurological conditions that contribute to disorders. Emphasizes a comparative and multidisciplinary approach to the topic of sleep Covers the neurobiology and physiology of sleep stages, mechanisms of waking, and dreaming Discusses in detail the proposed functions of sleep, from health and rest, to memory consolidation and synaptic plasticity Examines the current state of research in mammalian and non-mammalian species, ranging from primates to invertebrates

The Neurobiology of Circadian Timing

However, it has been recently proposed that sleep is local in nature, ... Moreover, experimental studies have shown that sleep and wakefulness can be ...

The Neurobiology of Circadian Timing

Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Modern Approaches to Augmentation of Brain Function

J Neurosci 17:409–419 Siclari F, Tononi G (2017) Local aspects of sleep and wakefulness. Curr Opin Neurobiol 44:222–227 Siengsukon CF, Boyd LA (2008) Sleep ...

Modern Approaches to Augmentation of Brain Function


Dynamic Structure of NREM Sleep

The main aspect was the amount of prior wakefulness, considered by Wilse B. ... Later, when local aspects of sleep regulation were increasingly evident, ...

Dynamic Structure of NREM Sleep

Dynamic Structure of NREM Sleep is a concise guide to Cyclic Alternating Pattern (CAP) phenomenology and slow wave homeostasis. It presents an original approach to a specialized aspect of sleep neuroscience in a concise and easy-to-read format. The authors are specialists in the field of sleep neuroscience and lend a new perspective to the benefits of slow wave activity during sleep. The main feature of this discussion is that slow wave activity increases as a function of previous wakefulness and it gradually decreases in the course of sleep. Alongside developing this idea, this book covers the entire range of sleep issues from basic structure to function in comprehensive detail. Dynamic Structure of NREM Sleep is valuable reading for neurologists, sleep neuroscientists and those with an interest in the field.

Adenosine

The local aspect of sleep has particularly been addressed in experiments where local brain areas have been stimulated during waking either by natural ...

Adenosine

Homeostasis of key metabolites and metabolic health affects all bodily systems. Not surprisingly, altered metabolic function is associated with a wide spectrum of dysfunctions in the central nervous system – including developmental disorders, acute nervous system injury, and neurodegenerative disorders. Accordingly, metabolism-based therapies offer significant promise as new category of treatment options designed to limit, delay or reverse the disease process by reconstructing homeostatic functions. Increasingly it is appreciated that restoring metabolic health could promote normal nervous system activity, and improve behavior and cognition. Adenosine: A Key Link Between Metabolism and Central Nervous System Activity focusses on diverse aspects of adenosine, an evolutionarily conserved homeostatic bioenergetic regulator in the central nervous system. Because of its interrelationship with ATP (adenosine triphosphate), adenosine is integral to cell metabolism. At the same time, adenosine influences neuronal activity directly via receptors, and is involved in biochemical processes related to gene expression. Thus, adenosine is uniquely placed as a reciprocal and rapid link between changes in metabolism and changes in neuronal activity, and, on a longer time scale, to changes in gene expression and long term changes in cell function. Leaders in the field feature basic research on adenosine at the cellular level in the central nervous system, and relate these findings to its recognized potential in diverse acute and chronic disorders. This comprehensive overview of adenosine also highlights emerging adenosine-based treatments and associated opportunities for central nervous system disorders.

Principles and Practice of Sleep Medicine E Book

... trait.142,145 Thus basic features of the homeostatic process are present throughout the sleep-wake cycle, suggesting that sleep and waking could be seen ...

Principles and Practice of Sleep Medicine E Book

For nearly 30 years, Dr. Meir Kryger’s must-have guide to sleep medicine has been the gold standard in this fast-changing field. This essential, full-color reference includes more than 20 unique sections and over 170 chapters covering every aspect of sleep disorders, giving you the authoritative guidance you need to offer your patients the best possible care. Evidence-based content helps you make the most well-informed clinical decisions. An ideal resource for preparing for the sleep medicine fellowship examination. New content on sleep apnea, neurological disorders, legal aspects of sleep medicine, dental sleep medicine genetics, circadian disorders, geriatrics, women’s health, cardiovascular diseases, and occupational sleep medicine, keeps you fully up to date. Updates to scientific discoveries and clinical approaches ensure that you remain current with new knowledge that is advancing the diagnosis and management of sleep disorders.

The Oxford Handbook of Sleep and Sleep Disorders

The regulation of the various aspects of sleep varies with respect to the ... for SWA increases in a saturating exponential way during wakefulness and, ...

The Oxford Handbook of Sleep and Sleep Disorders

From the ancients to the present day, the importance of sleep has seldom been disputed, but it has never had top billing in comparison to other components of healthy living. Now, however, it seems that the combined critical mass of research, the needs of the population, and the shifting weight of professional interest is pushing sleep to the academic and research forefront. The Oxford Handbook of Sleep and Sleep Disorders provides a comprehensive and state-of-the-art review of knowledge about current research and clinical developments in normal and abnormal sleep. The handbook comprises three sections: Section I covers the basics of normal sleep, its functions, and its relationships to emotions, cognitions, performance, psychopathology, and public health and safety issues. Section II addresses abnormal sleep, including disorders like insomnia, parasomnias, circadian rhythm disorders, and sleep apnea. An informed classification of sleep/wake disorders is presented along with a protocol for assessing sleep-wake complaints and evidence-based treatment options. Section III provides a developmental perspective on sleep and sleep problems in childhood, adolescence, and in late life, and a discussion of sleep disturbances in selected special populations. Written by eminent international experts from diverse fields of study and clinical backgrounds, this handbook is a comprehensive resource that will meet the needs of clinicians, researchers, and trainees with an interest in the multidisciplinary and emerging field of sleep medicine.

The American Psychiatric Association Publishing Textbook of Psychiatry Seventh Edition

Sleep 30(11):1445–1459, 2007 18041479 Morin CM, Benca R: Chronic insomnia. ... 201121344054 Siclari F, Tononi G: Local aspects of sleep and wakefulness.

The American Psychiatric Association Publishing Textbook of Psychiatry  Seventh Edition

Preceded by American Psychiatric Publishing textbook of psychiatry / edited by Robert E. Hales, Stuart C. Yudofsky, Laura Weiss Roberts. Sixth edition. 2014.

Local Serial Correlation in Behavioral States in the Mouse

In the mouse, Mus musculus, local (ultradian) serial correlation (LSC) within the sleep and wakefulness states varies significantly as a function of circadian phase.

Local Serial Correlation in Behavioral States in the Mouse

In the mouse, Mus musculus, local (ultradian) serial correlation (LSC) within the sleep and wakefulness states varies significantly as a function of circadian phase. The amplitude of the correlation function is greatest during the active phase of the mouse's diurnal cycle. Additionally, mean LSC (averaged across circadian phase) is significantly positive and monotonically decreasing for a broad range of short lags (1-23 minutes). Thus there is no evidence of positive, periodically occurring peaks in the correlation function separated by patches of small or negative correlations that is characteristic of a rhythmic process of fixed period. These findings challenge the concept that an ultradian oscillator plays a significant role in the temporal control of sleep-wake state. (Author).

Sleep Epilepsies and Cognitive Impairment

Its global nature has been challenged by those data pointing to the existence of local/regional features of sleep and wake states.

Sleep  Epilepsies  and Cognitive Impairment

Translational research connects science and clinical medicine from "the bench to the bedside." In Sleep, Epilepsies and Cognitive Impairment, the authors look back from the bedside to the brain function underlying clinical symptoms and reveal mechanisms explored by contemporary neuroimaging and signal analysis in the overlapping fields of sleep and epilepsy. This book will help the reader to see epilepsy from a new viewpoint. The common pathophysiology binding together the diverse manifestations of epilepsies is the exaggeration of plastic functions of the brain involving the hippocampus, the non-specific thalamocortical system and the perisylvian cognitive network. Epileptic derailment seems to be the price for the latest achievements of the mammal and human brain; namely the highly developed ability to change and learn. The contemporary results of sleep research provide new viewpoints to explain why sleep and epilepsy are bedfellows. Converging evidence supports the concept that one of the most important biological roles of NREM sleep is the renewal of synaptic balance ensuring learning ability from one day to the next and consolidation of new memories. Epilepsy and NREM sleep use overlapping structures and functions, therefore epilepsy beginning in early childhood may interfere with sleep plastic functions. NREM sleep, which affects original learning and memory, may become the hidden source of chronic cognitive impairment when epilepsy occurs during sleep and blocks the plastic processes. Sleep, Epilepsies and Cognitive Impairment abandons the academic classification of epilepsy by following the system epilepsy concept, binding major epilepsies with structures and functions of physiological brain systems. It tries to show within this system the close interrelationship between sleep, epilepsy and cognition. Neuroscientists, clinical epileptologists and neurologists interested in brain processes underlying brain plasticity, sleep and epilepsy will find this book thought provoking. It offers good "brain-gymnastics" for reconsidering the ideas on epilepsy. It provides contemporary knowledge about the neurophysiological and functional anatomical background of major epilepsies Treats major epilepsies as system epilepsies of brain networks Reveals the interrelationship of sleep, epilepsy and cognitive impairment showing how epileptic manifestations became facilitated in NREM sleep and interferes with sleep plastic functions

Narcolepsy

Hishikawa Y, Shimizu T. Physiology of REM sleep, cataplexy, and sleep paralysis. ... Pigorini A, De Carli F, Ferrara M. Local aspects of sleep: observations ...

Narcolepsy

This comprehensive resource covers the current thoughts and trends on narcolepsy, as well as cutting-edge evidence-based research. Updates from the previous edition include advances in diagnostic guidelines, treatments, protocols and clinical and psychosocial considerations. Aspects of narcolepsy relating to sleep medicine, neurology, psychiatry and public health are featured throughout the text. Narcolepsy, 2nd Edition provides clinicians and allied health professionals with patient management modalities, clinical and quality of life issues and best practices for health care delivery.

Sleep Disorders Medicine

Basic Science, Technical Considerations and Clinical Aspects Sudhansu ... Cirelli C et al (2013) Local experience-dependent changes in the wake EEG after ...

Sleep Disorders Medicine

Since publication of the first edition in 1994, the second edition in 1999, and the third edition in 2009, many new advances in sleep medicine have been made and warrant a fourth edition. This comprehensive text features 19 additional chapters and covers basic science, technical and laboratory aspects and clinical and therapeutic advances in sleep medicine for beginners and seasoned practitioners. With the discovery of new entities, many new techniques and therapies, and evolving basic science understanding of sleep, Sleep Disorders Medicine, Fourth Edition brings old and new knowledge about sleep medicine together succinctly in one place for a deeper understanding of the topic. Neurologists, internists, family physicians, pediatricians, psychiatrists, psychologists, otolaryngologists, dentists, neurosurgeons, neuroscientists, intensivists, as well as those interested in advancing their knowledge in sleep and its disorders, will find this edition to be an invaluable resource to this bourgeoning field.

Rapid Eye Movement Sleep Behavior Disorder

Dissociated wake-like and sleep-like electro-cortical activity during sleep. ... Pigorini A, De Carli F, Ferrara M. Local aspects of sleep: observations ...

Rapid Eye Movement Sleep Behavior Disorder


New Oxford Textbook of Psychiatry

111.1 Key aspects of sleepwake behaviour can be assessed ... insufficient sleep to be roughly between 1% and 3% of the gross domestic product (GDP) in the ...

New Oxford Textbook of Psychiatry

Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has been updated throughout to include the most recent versions of the two main classification systems—-the DSM-5 and the ICD-11—-used throughout the world for the diagnosis of mental disorders. In the years since publication of the first edition, many new and exciting discoveries have occurred in the biological sciences, which are having a major impact on how we study and practise psychiatry. In addition, psychiatry has fostered closer ties with philosophy, and these are leading to healthy discussions about how we should diagnose and treat mental illness. This new edition recognises these and other developments. Throughout, accounts of clinical practice are linked to the underlying science, and to the evidence for the efficacy of treatments. Physical and psychological treatments, including psychodynamic approaches, are covered in depth. The history of psychiatry, ethics, public health aspects, and public attitudes to psychiatry and to patients are all given due attention.

Cannabinoids and Sleep

Molecular, Functional and Clinical Aspects Jaime M. Monti, S. R. Pandi-Perumal, Eric Murillo-Rodríguez. A. Wakefulness NREM REM B. ) 20 delta EEG 15 G E V( ...

Cannabinoids and Sleep

Research on cannabis and sleep is emerging with promising results. This book offers current and comprehensive knowledge on cannabinoid research results in connection with sleep. The volume covers aspects of the hemp plant Cannabis sativa, the pharmacology of cannabinoids, neurobiology and pharmacology of sleep and wakefulness, and the benefits and side effects of cannabis on the central nervous system. It further discusses the putative therapeutical properties of cannabinoids and endocannabinoids and their potential for the treatment of sleep disorders such as insomnia, obstructive sleep apnea, REM sleep behavior disorder, and restless legs syndrome. The book is written by medical and scientific experts in this field and intended for researchers from a range of disciplines such as biomedicine, biology, neurosciences, clinical medicine, neurology, and pharmacology.

The Genetic Basis of Sleep and Sleep Disorders

Recently, the detailed analysis of its dynamics has led to a paradigm shift in how we view sleep; the local and use-dependent aspects of SWA suggest that ...

The Genetic Basis of Sleep and Sleep Disorders

The first comprehensive book on the subject, The Genetic Basis of Sleep and Sleep Disorders covers detailed reviews of the general principles of genetics and genetic techniques in the study of sleep and sleep disorders. The book contains sections on the genetics of circadian rhythms, of normal sleep and wake states and of sleep homeostasis. There are also sections discussing the role of genetics in the understanding of insomnias, hypersomnias including narcolepsy, parasomnias and sleep-related movement disorders. The final chapter highlights the use of gene therapy in sleep disorders. Written by genetic experts and sleep specialists from around the world, the book is up to date and geared specifically to the needs of both researchers and clinicians with an interest in sleep medicine. This book will be an invaluable resource for sleep specialists, neurologists, geneticists, psychiatrists and psychologists.

Serotonin and Sleep Molecular Functional and Clinical Aspects

... 5-HT cell activity over the sleep-wake cycle since Gervasoni and collaborators ... in addition to the effects of the neuropeptide on local interneurons.

Serotonin and Sleep  Molecular  Functional and Clinical Aspects

This book focuses on the neuropsychopharmacology of serotonin and its role in sleep and wakefulness, presenting neurochemical, electrophysiological, and neuropharmacological approaches to understand the mechanisms of serotonin and related substances. Covering core and contemporary topics in the area, this volume is valuable for all researchers interested in interdisciplinary studies concerning drugs affecting the central nervous system.