This book includes chapters on translational topics in vascular medicine that are commonly overlooked in research reviews and vascular medicine texts. Throughout the book, the authors communicate complex molecular mechanisms using ...
Author: Jonathon W. Homeister
Publisher: Springer Science & Business Media
Molecular and Translational Vascular Medicine will serve as a state-of-the-art resource for physicians and translational medical researchers alike who are interested in the rapidly evolving field of vascular medicine. The text provides new insight into the basic mechanisms of classic vascular pathophysiologic processes like angiogenesis, atherosclerosis, thrombosis, and vasculitis. Furthermore, it covers new areas of investigation including the role of the ubiquitin proteasome system in vascular disease, endothelial progenitor cells for disease treatment, and the genetic basis of thoracic aortic aneurysms. Lastly, this volume includes sections on the newly emerging field of therapeutic angiogenesis, and the developing technology of nanoparticle-based imaging and therapeutic treatment of the diseased vasculature. All chapters are written by established experts in their fields, including pathologists, cardiovascular surgeons, and internists as well as translational biomedical researchers in a wide range of disciplines. While comprehensive, the material is presented in a manner that simplifies the complex pathophysiologic mechanisms that underlie common vascular diseases. Molecular and Translational Vascular Medicine will be of great value to a broad audience including internists, cardiovascular and vascular surgeons, pathologists, residents and fellows, as well as translational biomedical researchers.
David Abraham • Clive Handler Michael Dashwood • Gerry Coghlan Editors Translational Vascular Medicine Pathogenesis, Diagnosis, and Treatment Editors David Abraham, PhD Professor of Cellular and Molecular Biology Translational Vascular ...
Author: David Abraham
Publisher: Springer Science & Business Media
Translational medicine underpins vascular medicine. It is fundamental to understanding how we treat patients with vascular disease and more importantly, how to prevent it. It is the rationale for drug design and production. Vascular medicine and translational medicine will take over and become the main reason for referring patients to hospital. Therefore, hospital-based clinicians working with basic scientists need to know about translational medicine, which educates and informs them about vascular medicine and how management should be based. This book is a primer for translational vascular medicine and discusses the evolving and exciting areas of basic science applied to vascular medicine. The book is based on the third vascular biology conference held at The Royal College of Physicians in 2008. It provides a large amount of new basic and clinical information and the contributors are world leaders.
... Commonwealth Professor of Pediatrics Harvard Medical School Boston, Massachusetts Uwe Raaz, MD Molecular and Translational Vascular Medicine Department of Cardiology and Pneumology University Heart Center Göttingen Göttingen, ...
Author: Mark Creager
Publisher: Elsevier Health Sciences
With authoritative coverage of everything from recent discoveries in the field of vascular biology to recent clinical trials and evidence-based treatment strategies, Vascular Medicine, 3rd Edition, is your go-to resource for improving your patients’ cardiovascular health. Part of the Braunwald family of renowned cardiology references, this updated volume integrates a contemporary understanding of vascular biology with a thorough review of clinical vascular diseases, making it an ideal reference for vascular medicine specialists, general cardiologists, interventional cardiologists, vascular surgeons, and interventional radiologists. Incorporates technologic advances in vascular imaging – including ultrasound, MRI, CTA, and catheter-based angiography – along with more than 230 new figures, providing an up-to-date and complete view of the vascular system and vascular diseases. Covers novel antithrombotic therapies for peripheral artery disease and venous thromboemboism, advances in endovascular interventions for aortic aneurysms, and today’s best surgical treatments for vascular diseases. Includes seven new chapters: Pathobiology of Aortic Aneurysms; Pathobiology and Assessment of Cardiovascular Fibrosis; Large Vessel Vasculitis; Medium and Small Vessel Vasculitis; Epidemiology and Prognosis of Venous Thromboembolic Disease; Fibromuscular Dysplasia; and Dermatologic Manifestations of Vascular Disease. Discusses methods for aggressive patient management and disease prevention to ensure minimal risk of further cardiovascular problems. Keeps you current with ACC/AHA and ECC guidelines and the best ways to implement them in clinical practice.
The ubiquitin proteasome system in endothelial cell dys- function and vascular disease. In: Homeister, J.W., Willis, M.S. (Eds.), Molecular and Translational Vascular Medicine, vol. XIV. Humana, New York, pp. 103–127.
Author: Kwang W. Jeon
Publisher: Academic Press
International Review of Cell and Molecular Biology presents comprehensive reviews and current advances in cell and molecular biology. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. The series has a world-wide readership, maintaining a high standard by publishing invited articles on important and timely topics authored by prominent cell and molecular biologists. Authored by some of the foremost scientists in the field Provides comprehensive reviews and current advances Wide range of perspectives on specific subjects Valuable reference material for advanced undergraduates, graduate students and professional scientists
Molecular regulation of vasculogenesis and angiogenesis: Recent advances and future directions. In J. W. Homeister & M. S. Willis (Eds.), Molecular and translational vascular medicine (pp. 169–206). New York: Springer.
Publisher: Academic Press
Endothelium, the new volume in the Advances in Pharmacology series, presents readers with a variety of chapters that cover various endothelium-derived mediators and their changes with gender, and during vascular development, senescence, and hypertensive disorders. Topics include endothelium, nitric oxide, gap junctions, potassium channels, endothelin, vascular development, vascular permeability, gender, aging, and preeclampsia. With contributions from the best authors in the field, the volume is an essential resource for pharmacologists, immunologists, and biochemists alike. Contains contributions from the best authors in the field Provides an essential resource for pharmacologists, immunologists, and biochemists Covers endothelium-derived mediators and their changes
“Molecular biology and genetics of aortic aneurysms,” in Molecular and Translational Vascular Medicine, eds M. S. Willis, and J. W. Homeister (NewYork, NY: Springer Science+Business Media, Part 1), 3–33. doi:10.1007/978-1-61779-906-8_1 ...
Author: Mariza de Andrade
Publisher: Frontiers Media SA
This eBook contains the 19 articles that were part of a Special Topic in Frontiers in Genetics entitled “Genetics Research in Electronic Health Records Linked to DNA Biobanks”. The Special Issue was published on-line in 2014-2015 and contained papers representing the diverse research ongoing in the integration of electronic health records (EHR) with genomics through basic, clinical, and translational research. We have divided the eBook into four Chapters. Chapter 1 describes the Electronic Medical Records and Genomics (eMERGE) network and its contri-bution to genomics. It highlights methodological questions related to large data sets such as imputation and population stratification. Chapter 2 describes the results of genetic studies on different diseases for which all the phenotypic information was extracted from the EHR with highly specific ePhenotyping algorithms. Chapter 3 focuses on more complex analyses of the genome including copy number variants (CNV), pleiotropy com-bined with phenome-wide association studies (PheWAS), and epistasis (gene-gene interactions). Chapter 4 discusses the use of genetic data together with EHR-derived clinical data in clinical settings, and how to return genetic results to patients and providers. It also contains a comprehensive review on genetic risk scores. We have included mostly Original Research Articles in the eBook, but also Reviews and Methods papers on the relevant topics of analyzing and integrating genomic data. The release of this eBook is timely, since several countries are launching Precision Medicine initiatives. Precision Medicine is a new concept in patient care taking into account individual variability in genetic, environmental and lifestyle factors, when treating diseases or trying to prevent them from developing. It has become an important focus for biomedical, clinical and translational informatics. The papers presented in this eBook are well positioned to educate the readers about Precision Medicine and to demonstrate the potential study designs, methods, strategies, and applications where this type of research can be performed successfully. The ultimate goal is to improve diagnostics and provide better, more targeted care to the patient.
This book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management.
Author: Paula E. North
This book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management. It offers a new multidisciplinary resource for clinicians, pathologists, molecular diagnosticians, and scientists in the field of vascular medicine and biology, fostering cross-cutting collaboration in clinical practice and research. Fundamental background information on vascular tumors and malformation is provided, while also including the most current information available on pathogenic mechanisms underlying this heterogenous group of disorders and the implications for molecular diagnosis and therapeutic intervention. Written by experts in the field, Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis provides the medical and scientific community with an essential, practical resource to guide accurate diagnosis, well-targeted therapies, and informed investigation of specific clinicopathological entities within the spectrum of vascular anomalies.
Godin, B., Hu, Y., Francesca, S. and Ferrari, M. (2012) Cardiovascular nanomedicine: Challenges and opportunities. In: Homeister, J. W. and Willis, M. S. (eds), Molecular and Translational Vascular Medicine, New York, Humana Press.
Author: Elena P. Ivanova
Publisher: Woodhead Publishing
Category: Technology & Engineering
New Functional Biomaterials for Medicine and Healthcare provides a concise summary of the latest developments in key types of biomaterials. The book begins with an overview of the use of biomaterials in contemporary healthcare and the process of developing novel biomaterials; the key issues and challenges associated with the design of complex implantable systems are also highlighted. The book then reviews the main materials used in functional biomaterials, particularly their properties and applications. Individual chapters focus on both natural and synthetic polymers, metallic biomaterials, and bio-inert and bioactive ceramics. Advances in processing technologies and our understanding of materials and their properties have made it possible for scientists and engineers to develop more sophisticated biomaterials with more targeted functionality. New Functional Biomaterials for Medicine and Healthcare provides an ideal one-volume summary of this important field that represents essential reading for scientists, engineers, and clinicians, and a useful reference text for undergraduate and postgraduate students. Provides a concise summary of the latest developments in key types of biomaterials Highlights key issues and challenges associated with the design of complex implantable systems Chapters focus on both natural and synthetic polymers, metallic biomaterials, and bio-inert and bioactive ceramics
In: Homeister, J.W. and Wills, M.S., Molecular and Translational Vascular Medicine. New York: Springer Science+Business Media. İpek, G., Karataş, M.B., Onuk, T. et al. (2015). Effectiveness and safety of thrombolytic therapy in elderly ...
Author: Gabriella Bettelli
Publisher: Cambridge University Press
This innovative, comprehensive book covers the key elements of perioperative management of older patients. The book's chapter structure coincides with the clinical path patients tread during their treatment, from preoperative evaluation to post-hospital care. Epidemiological aspects and aging processes are illustrated, providing keys to understanding the quick expansion of geriatric surgery and defining the clinical profile of older surgical patients in a cybernetic perspective. Preoperative evaluation and preparation for surgery, including medication reconciliation and pre-habilitation, are developed in the light of supporting decision-making about surgery in an evidence-based and patient-focused way. Intra- and postoperative management are discussed, aiming to tailor anesthetic, surgical and nursing approaches to specific patients' needs, in order to prevent both general and age-related complications. This volume also addresses issues relevant to geriatric surgery, from different organizational models to clinical risk management and systems engineering applied to hospital organization.
Gobin B, Hu Y, Lafracesca S, Ferraro M. Cardiovascular nanomedince: challenges and opportunities. In: Willis MS, Momeister J, editors. Molecular and translational vascular medicine. New York: Human Press; 2012. Dobson MG, Galvin P, ...
Author: Narenda Kumar
Publisher: William Andrew
Category: Technology & Engineering
Nanotechnology and Nanomaterials in the Treatment of Life-threatening Diseases takes a scientific approach to nanotechnology and nanomaterials applications in medicine, while also explaining the core biological principles for an audience of biomedical engineers, materials scientists, pharmacologists, and medical diagnostic technicians. The book is structured by major disease groups, offering a practical, application-based focus for scientists, engineers, and clinicians alike. The spectrum of medical applications is explored, from diagnostics and imaging to drug delivery, monitoring, therapies, and disease prevention. It also focuses specifically on the synthesis of nanomaterials and their potential health risks (particularly toxicity). Nanomedicine — the application of nanomaterials and devices for addressing medical problems — has demonstrated great potential for enabling improved diagnosis, treatment, and monitoring of many serious illnesses, including cancer, cardiovascular and neurological disorders, HIV/AIDS, and diabetes, as well as many types of inflammatory and infectious diseases. Gain an understanding of how nanotechnologies and nanomaterials can be deployed in the fight against the major life-threatening diseases: cancer, neurological disorders (including Alzheimer's and Parkinson's), cardiovascular diseases, and HIV/AIDS Discover the latest developments in nanomedicine, from therapies and drug delivery to diagnostics and disease prevention The authors cover the health risks of nanomaterials as well as their benefits, considering toxicity and potential carcinogens
Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1. Circulation. 2007;116:276–84. 5. Kircher MF, Grimm J, Swirski FK, Libby P, Gerszten RE, Allport JR, et al.
Author: Dennis V. Cokkinos
The term “Translational Research” reflects today’s integration of basic research (“bench”) findings with the clinical practice of medicine, and in a wider scope the application of results from the individual patient (“bedside”) to entire populations for the improvement of public health. This book offers future researchers a stimulus in many aspects of cardiovascular research, so as to promote their interest in future fields of cardiovascular disease, diagnosis and treatment. Introduction to Translational Cardiovascular Research discusses the fundamental and important aspects of the topic. It describes the renin-angiotensin-aldosterone system, the beta adrenergic receptors and the hypothalamic-pituitary-adrenal axis, while covering genetic polymorphisms both generally and specifically as regards the vascular endothelium and the use of microRNAs. As such, this book will be relevant to young physicians, nurses and other scientists engaged in the clinical cardiovascular field who want to added research-oriented dimension to their efforts towards better understanding and practicing of medicine. It also aims to attract young basic researchers who want to develop a better comprehension of the organism as a whole, man or animal, that they are investigating.
This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine.
Author: Monte Willis
Publisher: Academic Press
Cellular and Molecular Pathobiology of Cardiovascular Disease focuses on the pathophysiology of common cardiovascular disease in the context of its underlying mechanisms and molecular biology. This book has been developed from the editors' experiences teaching an advanced cardiovascular pathology course for PhD trainees in the biomedical sciences, and trainees in cardiology, pathology, public health, and veterinary medicine. No other single text-reference combines clinical cardiology and cardiovascular pathology with enough molecular content for graduate students in both biomedical research and clinical departments. The text is complemented and supported by a rich variety of photomicrographs, diagrams of molecular relationships, and tables. It is uniquely useful to a wide audience of graduate students and post-doctoral fellows in areas from pathology to physiology, genetics, pharmacology, and more, as well as medical residents in pathology, laboratory medicine, internal medicine, cardiovascular surgery, and cardiology. Explains how to identify cardiovascular pathologies and compare with normal physiology to aid research Gives concise explanations of key issues and background reading suggestions Covers molecular bases of diseases for better understanding of molecular events that precede or accompany the development of pathology
Journal of Cardiovascular Translational Research, 2009;2(4):441-51). For additional information, contact C. Ferrantini, University of Florence, Dept. of Physiology and Center of Molecular Medicine (CIMMBA), Florence, Italy.
Issues in Cardiovascular Medicine / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Cardiovascular Medicine. The editors have built Issues in Cardiovascular Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Cardiovascular Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Cardiovascular Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use.
Author: Jonathan C. Schisler
Publisher: Academic Press
Endocrinology of the Heart in Health and Disease: Integrated, Cellular, and Molecular Endocrinology of the Heart covers the traditional concepts of cardio-endocrinology, the role of the various hormone systems, both in health and disease, therapeutic implications, and other recent advances in the various fields represented. The book explores how cardiac hormones are changed in various cardiac pathologies and the recent success that has been uncovered in their therapeutic use. Additional focus is placed on how the heart responds both physiologically and pathophysiologically to a plethora of circulating hormones, reinforcing the importance of the heart as a target of numerous endocrine systems, such as the brain, renal, and adipose. Significant advances have come from basic, clinical, and translational research from a multiplicity of investigators with diverse backgrounds. The book features over 200 photomicrographs, diagrams of molecular relationships, and tables that complement and support the text. It is aimed at a wide audience, including graduate students and post-doctoral fellows in a wide array of biomedical departments and PhD programs (e.g. Pathology, Physiology, Genetics, Pharmacology, Molecular Biology, and Cell Biology) related to the endocrine and cardiovascular sciences curricula, as well as medical residents in pathology, laboratory medicine, internal medicine, and cardiology. Develops the concept of the heart as both an endocrine organ and an endocrine target, exploring the endocrine function of the heart in both health and disease Explains how the levels of several cardiac hormones are changed in various cardiac pathologies and how some hormones can be used therapeutically Offers a single resource on cardio-endocrine disease which collates and curates the wide range of advances being made in the areas of molecular biology, biochemistry, physiology, and pathology
... 3 Faculty of Medicine and Dentistry, Institute of Molecular and Translational Medicine, Palacky University, ... TLR4, epigenetics INTRODUCTION Specialty section: This article was submitted to Atherosclerosis and Vascular Medicine, ...
The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an ...
Author: Rhian M. Touyz
This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
With many innovative approaches at the cusp of clinical translation, the future for molecular imaging in cardiovascular medicine is bright. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. REFERENCES 1. Mankoff DA. A definition of molecular ...
Author: Ernest V. Garcia
Publisher: Oxford University Press, USA
Nuclear cardiac imaging refers to cardiac radiological diagnostic techniques performed with the aid of radiopharmaceuticals, which are perfused into the myocardium as markers. These imaging studies provide a wide range of information about the heart, including the contractility of the heart, the amount of blood supply to the heart and whether parts of the heart muscle are alive or dead. This is essential information for cardiologists, and nuclear imaging has become an increasingly important part of the cardiologist's armamentarium. Chapters in Nuclear Cardiac Imaging cover historical, technical and physiological considerations, diagnosis and prognosis, conditions other than Coronary Artery Disease (CAD), advanced cardiac imaging, and challenges and opportunities. New to the fifth edition are key point summaries at the start of each chapter, clinical cases with videos, and a question and answer chapter on practical issues. This volume is ideal for nuclear cardiologists in training and nuclear clinicians alike who are searching for quick answers to important clinical and technical questions.
CH 3 VSMC differentiation FIGURE 3-5 Model for regulation of vascular smooth muscle cell (VSMC) phenotypes by ... proposed that provide insights into the molecular mechanisms of translational inhibition, deadenylation, and mRNA decay, ...
Author: Mark Creager
Publisher: Elsevier Health Sciences
Make the most of today's innovative medical therapies, advances in vascular imaging, and new drugs to improve your patients' cardiovascular health with Vascular Medicine, 2nd Edition. This comprehensive, clinically-focused volume in the Braunwald's Heart Disease family provides an in-depth, state-of-the-art review of all vascular diseases, with an emphasis on pathophysiology, diagnosis, and management - giving you the evidence-based guidance you need to make appropriate therapeutic decisions on behalf of your patients. Consult this title on your favorite e-reader with intuitive search tools and adjustable font sizes. Elsevier eBooks provide instant portable access to your entire library, no matter what device you’re using or where you’re located. Gain a state-of-the-art understanding of the pathophysiology, diagnosis, and management of arterial disease, venous disease, lymph dysfunction, connective tissue disease, vascular disease, and vascular manifestations of systemic disease. Benefit from the knowledge and experience of Dr. Mark A. Creager (editor of the Vascular Medicine society journal), Dr. Joshua A. Beckman, and Dr. Joseph Loscalzo, and benefit from their practice rationales for all of today’s clinical therapies. Easily reference Braunwald’s Heart Disease, 9th Edition for further information on topics of interest. Get up-to-date information on new combination drug therapies and management of chronic complications of hypertension. Learn the best methods for aggressive patient management and disease prevention to ensure minimal risk of further cardiovascular problems. Stay current with ACC/AHA and ECC guidelines and the best ways to implement them in clinical practice. Enhance your visual perspective with an all-new, full-color design throughout. Utilize behavior management as an integral part of treatment for your hypertensive and pre-hypertensive patients. Effectively manage special populations with chronic hypertensive disease, as well as hypertension and concomitant disease. Access the complete contents online and download images at www.expertconsult.com.
MHC form dimeric molecules by association of their coiled-coil carboxyl terminal. Whether homodimeric or both homo- and heterodimeric, MHC association seems to be species-dependent. Thus, SM1 and SM2 homodimers are found in bovine aorta ...
Author: K. Lindpaintner
Publisher: Springer Science & Business Media
This book represents a cross-sectional account of the advances that the ability to probe the very roots of biological function have produced in the field of cardiovascular medicine. It arose from a series of articles published over the last few years in the Journal of Hypertension, bringing together an illustrous panel of experts from a broad spectrum of theoretical and applied areas of science.
Ingrid Fleming Institute for Vascular Signalling, Centre for Molecular Medicine, Goethe University, Frankfurt am Main, ... Geneva, Switzerland Justin C. Mason Vascular Sciences, Imperial Centre for Translational & Experimental Medicine, ...
Author: Robert Krams
Publisher: Oxford University Press
Atherosclerosis is the most significant cause of cardiovascular disease worldwide. Vascular biology is the key to understanding how atherosclerosis arises and operates. The ESC Textbook of Vascular Biology is a rich and clearly laid-out guide by leading European scientists providing comprehensive information on vascular physiology, disease, and reasearch. The textbook covers molecular findings and novel targets within the speciality while also providing the basics of vascular biology and disease pathophysiology. It also covers the major changes in the diagnosis, prevention and treatment of atherosclerosis that have occurred in recent years, developments and recent breakthroughs in the field are specifically highlighted. The official publication of the ESC Working Group on Arthrosclerosis and Vascular Biology, this print edition comes with access to the online version on Oxford Medicine Online, for as long as the edition is published by Oxford University Press. By activating your unique access code, you can read and annotate the full text online, follow links from the references to primary research materials, and view, enlarge and download all the figures and tables. The textbook particularly appeals to vascular biologists, cardiologists, and other practising clinicians.