Molecular Mechanisms of Neuronal Responsiveness

This volume includes contributions provided by prominent investigators in all these research areas.

Molecular Mechanisms of Neuronal Responsiveness

The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.

Molecular Mechanisms of Neuronal Responsiveness

Library of Congress Cataloging in Publication Data Molecular mechanisms of neuronal responsiveness. (Advances in experimental medicine and biology; v. 221) “Proceedings of a symposium of a national conference on molecular mechanism of ...

Molecular Mechanisms of Neuronal Responsiveness

The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.

Molecular and Cellular Mechanisms of Neuronal Plasticity

Ecto protein kinase activity on the external surface of intact neural cells. Nature 320, 67–69. Ehrlich, Y.H., Lenox. R.H., Kornecki, E. and Berry. W. eds. (1987). Molecular mechanisms of neuronal responsiveness. Adh Exper Med.

Molecular and Cellular Mechanisms of Neuronal Plasticity

Numerous studies have proven the biological basis of memory formation and have begun to identify the biochemical traces and cellular circuits that are formed by experience, and which participate int the storage of information in the brain, its retention for long durations, and its retrieval upon demand. Cells in the nervous system have the capability of undergoing extremely long-lasting alterations in response to hormonal, pharmacological, and environmental stimulations. The mechanisms underlying this neuronal plasticity are activated by experiential inputs and operate in the process of learning and the formation of memories in the brain. This volume presents research areas which have not been highlighted in the past. In addition to studies on the involement of functional proteins in neuronal adaptation, this volume presents recent developments on the critical roles of bioactive lipids and nucleotides in these processes. In addition to the widely studied role of second messengers, a review of studies on extracellular phosphorylation systems operating on the surface of brain neurons is presented.The first section of the volume presents studies of basic mechanisms operating in a wide range of adaptive processes. The second section presents recent advances in investigations that have demonstrated the clinical implications of this research. These include: state of the art use of transgenic models in studies of molecular and cellular mechanisms implicated in familial Alzheimer's disease and Amyotrophic Lateral Sclerosis; studies of specific proteins implicated in Alzheimer's disease, including an adapter that binds to the beta-amyloid precurser protein (beta-APP) and the microtubular protein Tau and its membrane-bound counterpart. The advantages of using cell culture models for elucidating the causes of neuronal degeneration and for identifying mechanisms of neuroprotection are also presented among the chapters in the section on clinical implications.

Cumulated Index Medicus

Neuroendocrinology 1986 ; J Endocrinol 1986 Aug ; 110 ( 2 ) : 279-85 Neural circuits involved in the control of LHRH ... eminence to secrete luteinizing Neuronal responsiveness to gonadotropin - releasing hormone Molecular mechanism of ...

Cumulated Index Medicus


National Library of Medicine Current Catalog

221 ) “ Proceedings of a symposium of a national conference on molecular mechanisms of neuronal responsiveness ... 8809310 GROWTH & DEVELOPMENT CONGRESSES Neural repair / ( edited by John Nicholls and John Treherne ) Cambridge : The ...

National Library of Medicine Current Catalog


Nucleotides and their Receptors in the Nervous System

(1987) Molecular mechanisms of neuronal responsiveness. Adv. Exper Med. Biol., Vol. 221. Plenum Press, New York. Ehrlich, Y.H. (1987) Extracellular protein phosphorylation in neuronal responsiveness and adaptation. Adv. Exp. Med.

Nucleotides and their Receptors in the Nervous System

The study of purinergic mechanisms has for long been focused on the actions of the nucleoside adenosine, whereby the contribution of nucleotides to the signaling systems has been underestimated. Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, this book offers a comprehensive update and overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metabolizing ecto-enzymes as well as the physiological functions of nucleotides in the nervous system. The physiology and molecular biology of receptors for ATP and other nucleotides are examined, as are the physiology and molecular biology of enzymes that hydrolyze extracellular nucleotides. At present, a pharmacology of the nucleotide signaling system is being developed. Of particular interest is the production of receptor subtype-specific antagonists and of drugs that selectively affect the extracellular lifetime of the nucleotide. An excellent source of reference for institutes of pharmacology, biochemistry, neurology, zoology, and physiology, and for the pharmaceutical industry.

Molecular Mechanisms of Hormone Actions on Behavior

At least in part, these actions of CORT reflect changes in the neuronal responsiveness to neuropeptides or neurotransmitters. Modulation of the activity of these brainstem neurons may be a key mechanism by which corticosteroids ...

Molecular Mechanisms of Hormone Actions on Behavior

A single volume of 31 articles, Mechanisms of Hormone Actions on Behavior is an authoritative selection of relevant chapters from the Hormones Brain and Behavior 2e MRW, the most comprehensive source of neuroendocrinological information assembled to date (AP June 2009). The study of hormones as they impact the brain and, subsequently, behavior is a central topic in neuroscience, endocrinology and psychiatry. This volume offers an overview of neuroendocrinological topics, approaching the subject from the perspective of the mechanisms which control hormone actions on behavior. Female, male and stress hormones are discussed at the cellular, behavioral and developmental level, and sexual differentiation of the development of hormone-dependent neuronal systems, neuropeptides/neuromodulators, and steroid-inducedneuroplasticity are addressed. There is simply no other current single-volume reference with such comprehensive coverage and depth. Authors selected are the internationally renowned experts for the particular topics on which they write, and the volume is richly illustrated with over 175 figures (over 50 in color). A collection of articles reviewing our fundamental knowledge of the mechanisms of neuroendocrinology, the book provides an essential, affordable reference for researchers, clinicians and graduate students in the area. - The most comprehensive single-volume source of up-to-date data on the mechanisms behind neuroendocrinology, with review articles covering x,y z - Chapters synthesize information otherwise dispersed across a number of journal articles and book chapters, thus saving researchers the time consuming process of finding and integrating this information themselves - Offering outstanding scholarship, each chapter is written by an expert in the topic area and approximately 35% of chapters are written by international contributors - Provides more fully vetted expert knowledge than any existing work with broad appeal for the US, UK and Europe, accurately crediting the contributions to research in those regions - Heavily illustrated with 175 figures, approximately 54 in color - Presents material in most visually useful form for the reader

Biomedical Advances in Aging

Lapetina, E. G., 1987, The role of GTP binding proteins in receptor activation of phospholipase C, in: Molecular Mechanism of Neuronal Responsiveness (Y. H. Ehrlich, R. H. Lenox, E. Kornecki, and O. W. Berry, eds.) ...

Biomedical Advances in Aging

The VIIIth Annual International Spring Symposium on Health Sciences held at the George Washington University School of Medicine in Washington, D.C., attracted over three hun dred fifty scientists from twenty-five countries. The leading scientific experts in the field reported on recent biomedical advances in aging. They provided an up-to-date account of the molecular, genetic, nutritional, and immunological mechanisms associated with the aging process and approaches to intervention and treatment of the major disorders associated with the aging process, including Alzheimer's disease. A unique aspect of this meeting was a concurrent one-day hearing of the U.S. Senate Sub-Committee on Aging, organized by the Alliance for Aging Research. The theme for the hearing was "Advances in Aging Research." Seven scientists attending our aging sym posium were asked to testify. They were Drs. Carl Cotman (University of California-Irvine), Trudy Bush (Johns Hopkins University), Takashi Makinodan (University of California-Los Angeles), William Ershler (University of Wisconsin-Madison), Gino Doria (ENEA, Rome), Mr. Dan Perry (Director of the Alliance for Aging Research), and myself.

Dietary 3 and 6 Fatty Acids

Aveldano de Caldironi, M. I., and Bazan, N. G., 1977, Acyl groups, molecular species and labeling by l C-glycerol and ... phospholipids at the synapse in neuronal responsiveness, in: "Molecular Mechanisms of Neuronal Responsiveness", ...

Dietary   3 and   6 Fatty Acids

On June 24-26, 1985, a major International Conference on the Hea1th Effects of P01yunsaturated Fatty Acids in Seafoods was held in Washington, D. C. The conference had two objectives: (1) to review the research data on the health effects of polyunsaturated fatty acids in seafoods in terms of the impact of omega-3 fatty acids on eicosanoid formation, thrombosis and inflammation, and the role of docosahexaenoic acid in membrane function and metabolism, and (2) to develop a research agenda to determine the spectrum of the health effects of polyunsaturated fatty acids of seafood origin in the American diet. The 1985 conference established the fact that omega-3 fatty acids of marine origin - eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) - play important roles in prostaglandin metabolism, thrombosis and atherosc1erosis, immunology and inflammation, and membrane function. In response to the conference recommendations, the Congress of the United States provided special funding for the establishment of a "test materials 1aboratory" within the US Department of Commerce to produce under documented quality contr01 the types and quanti ties of omega-3 te~3t materials required by biomedica1 researchers. The forms of test materials to be produced include refined fish oil, polyunsaturated fatty acid enhanced triglycerides, concentrates of esters of fatty acids, purified omega-3 fatty acids, and omega-3 mono-, di- and tri~lyceride mixtures.

Psychopharmacology Bulletin

Molecular Mechanisms of Neuronal Responsiveness . Adv . Exp . Med . Biol . Vol . 221 . New York : Plenum Press , 1987. pp . 515-530 . Lenox , R.H. Lithium interaction with the phosphoinositide system and protein kinase C in the nervous ...

Psychopharmacology Bulletin


Technical Reports Awareness Circular TRAC

USAF SAM - JA - 86-12 SUPPLEMENTARY NOTE : Pub . in Molecular Mechanisms of Neuronal Responsiveness , p237-281 1987 . AD - A208 068 8/12 13/2 5/2 UNCLASSIFIED REPORT COLD REGIONS RESEARCH AND ENGINEERING LAB HANOVER NH CRREL ( Cold ...

Technical Reports Awareness Circular   TRAC


The Use of Animals in Research by the Department of Defense

Molecular Mechanisms of Acidic Amino Acid Release from Mossy Fiber Terminals of Rat Cerebellum . 1987 , USAFSAM - JA - 8612 Pub . in Molecular Mechanisms of Neuronal Responsiveness , Yigal H. Ehrlich , et al .

The Use of Animals in Research by the Department of Defense


The Guanine Nucleotide Binding Proteins

Rasenick, M.M., Marcus, M. M., Hatta, Y., DeLeon-Jones, F. and Hatta, S., 1987, Regulation of nueronal adenylate cyclase, In: Molecular mechanisms of neuronal responsiveness, pp. 123-133, Eds. Y. Erlich, R. Lenox, ...

The Guanine     Nucleotide Binding Proteins

This volume contains the proceedings of the EMBO-NATO-CEC Advanced Research Workshop on "Guanine-nucleotide binding proteins. Common structural and functional properties", which was held in Renesse, The Netherlands, August 6-11, 1988. The transmission of information is one of the most important processes in cellular life and involves the most diverse physiological functions. The cellular membrane, as the obligatory target for external signals, harbours complex pathways transducing the signals from the receptors of the external stimuli to the cytoplasmic effector. Heterotrimeric proteins are fundamental components of these pathways. Other proteins that are monomeric may be found associated with the membrane or in soluble form in the cytoplasm, and' can also function in signal transduction. Intracellular transmission of signals may proceed in an analogous fashion, protein synthesis being a well-known example. It is one of the most remarkable and puzzling observations of recent years that all of these proteins share common properties, both functionally and structurally. The ir primary structures show pronounced s imilari ties, in most cases concentrated in the NH2-terminal portion of the molecule. They all bind guanine nucleotides (hence the general name of G-proteins) and are GTPases, a crucial enzymatic activity, since it converts the active complex induced by GTP into the inactive one induced by GDP. Consensus sequences have been ident if ied as responsable for interact ing with the different parts of the guanine nucleotide.

NIDA Research Monograph

Washington , D.C .: Supt . of Docs . U.S. Govt . Print . Off . 1984 . pp . 260-292 . Crain , S.M. and Makman , M.H. In Ehrlich , Y.H. , ed . Molecular Mechanisms of Neuronal Responsiveness . New York , Plenum Press , 1986 ( in press ) .

NIDA Research Monograph


New Directions in Understanding Dementia and Alzheimer s Disease

Isolation of low molecular-weight proteins from amyloid plaque fibers in Alzheimer's disease. J. Neurochem, 46:1820-1834. ... In: (eds) Ehlich, Y. H., Lenox, R. H., Koraecki, E., Molecular mechanisms of neuronal responsiveness.

New Directions in Understanding Dementia and Alzheimer   s Disease

The management of Alzheimer's Disease and the related dementias is one of the major challenges to health care professionals and American society-at-large for the coming decade and the coming millennium. The rapid growth of the over-eighty-five population, the group which, as recent studies have confirmed and as many of us clinicians have long suspected, has an even higher prevalence than previously quoted of dementing disorders, is the major cause of this. We are thus challenged by, as Bernard Issacs used to call it, "the survival of the unfittest," as well as the oPtimistic approach of "bringing life to years," as John F. Kennedy said. The fact is that we, as a society, tend to confuse "treatment" and "cure" (and "prevention"). As the proceedings of the conference which this book represents emphasize, there is considerable work going on about the potential prevention of, or at least the reduction of, symptomatology in these illnesses by interventions genetically, chemIcally, and so forth. However, the more we find out, the more complicated it becomes, and the more heterogeneous Alzheimer's and the related disorders appear to be, not only in their manifestations (as clinicians have long recognized) but also in the individual initiating and underlying processes. For these reasons, absolute preventive techniques or the likelihood of an intervention which will reverse the process in a high proportion of patients, do not appear to be just around the corner.

Continuous Transcutaneous Monitoring

... MOLECULAR MECHANISMS OF NEURONAL RESPONSIVENESS Edited by Yigal H. Ehrlich, Robert H. Lenox, Elizabeth Kornecki, and William O. Berry A Continuation Order Plan is available for this series. A continuation order will bring delivery ...

Continuous Transcutaneous Monitoring

The i nterna ti ona 1 symposi a on transcutaneous monitori ng have dea It with the interaction between ideas and research, the introduction of unconventional techniques into clinical practice, and the joint efforts of researchers, clinicians, and industry to design and manufacture prac tical equipment for noninvasive monitoring. The First International Symposium on Continuous Transcutaneous Blood Gas Monitoring took place in Marburg, West Germany, from May 31 to June 2, 1978. This was the first major international meeting exclusively devoted to transcutaneous blood gas monitoring, and it was attended by the scientists who had developed this technique or had been \'Jorking with it, by a large number of doctors, mainly neonatologists who had just begun to use the technique or hoped to do so, and, finally, a rather large number of representatives of industry. The second symposium, with the same title, was held in Zurich, Switzerland, October 14-16, 1981. This time the focus was, to a large extent, on transcutaneous PC0 monitori ng, for whi ch equipment had become 2 commercially available only a short time before. Fetal monitoring was also discussed at length, as was the use of the transcutaneous techniques in other fields, such as vascular surgery and experimental animal research. The third symposium, October 1-4, 1986, was again held in Zurich. It \'Jas entitled "Continuous Transcutaneous Monitoring," indicating that not only blood gases but also other parameters could be monitored trans cutaneous ly.

The Role of Serotonin in Psychiatric Disorders

In Y. H. Ehrlich , R. H. Lenox , E. Kornecki , & W. O. Berry ( Eds . ) , Molecular mechanisms of neuronal responsiveness ( pp . 489-502 ) . New York : Plenum Press . Van Nueten , J. M. , Janssens , W. J. , & Vanhoutte , P. M. ( 1985a ) ...

The Role of Serotonin in Psychiatric Disorders

Presents the knowledge to date on the role of serotonin (5-hydroxytryptamine, or 5-HT) in the major psychiatric disorders and addresses the clinical relevance of data derived from research in this area. Following three chapters on biological underpinnings, eight chapters cover specific psychiatric

Oxygen Transport to Tissue X

... Everett Anderson, and Satya P. Kalra Volume 220 CONTINUOUS TRANSCUTANEOUS MONITORING Edited by Albert Huch, Renate Huch, and Gosta Rooth Volume 221 MOLECULAR MECHANISMS OF NEURONAL RESPONSIVENESS Edited by Yigal H. Ehrlich, ...

Oxygen Transport to Tissue X

The International Society on Oxygen Transport to Tissue (ISOTT) was founded in 1973 "to facilitate the exchange of scientific information among those interested in any aspect of the transport and/or utilization of oxygen in tissues". Its members span virtually all disciplines, ex tending from various branches of clinical medicine such as anesthesiology, ophthalmology and surgery through the basic medical sciences of physiology and biochemistry to the physical sciences and engineering. The fifteenth annual meeting of ISOTT was held in 1987 for three days, from July 22 to 24, at Hokkaido University in Sapporo, Japan. Previously, all ISOTT meetings had been held in Europe or the USA alternatively. This time, however, the meeting was held for the first time in an Asian country. When we first started preparing for this meeting some of our members were afraid that the number of those attending would not exceed '30. Fortunately the results were quite different. We had more than 60 participants from abroad and an even greater number from Japan. In addition to three special lectures and two symposia there were a total of 88 posters presented over the three days of the meeting. These covered all aspects of physiological oxygen transport including convection, diffusion, chemical reaction, and control of oxygen demand in blood and various tissues as well as the methods, models and instrumentation for their study. The 92 papers which comprise this volume encompass all of these areas.

Biomedical Index to PHS supported Research

... Growth factor control of early response gene P60AR - 20582-14 0004 Multipurpose arthritis center - Sensitivity to IGF ... Washington University Alzheimer's disease research center - Molecular mechanisms of natural occurring neuronal ...

Biomedical Index to PHS supported Research


Neuropsychopharmacology

Activation of the Wnt signaling pathway : a molecular mechanism for lithium action . ... Temporal dissociation between lithium - induced CNS myo - inositol changes and clinical response in manic - depressive illness .

Neuropsychopharmacology

Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of all neuropsychiatric disorders. Nine sections focus on specific groups of disorders, covering clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation. Compatibility: BlackBerry(R) OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile(TM) Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC