Mouse Genetics

This volume covers the field of mouse breeding and genetics at a level of detail sufficient for pursuing independent research.

Mouse Genetics

As nearly all human genes are present in the mouse genome, a growing number of biomedical researchers are finding they need to use the mouse as an experimental organism. This volume covers the field of mouse breeding and genetics at a level of detail sufficient for pursuing independent research.

Mouse Genetics After the Mouse Genome

The house mouse holds a unique place among model organisms, representing an indispensable tool for many investigators, particularly in biomedical research.

Mouse Genetics After the Mouse Genome

The house mouse holds a unique place among model organisms, representing an indispensable tool for many investigators, particularly in biomedical research. Mouse genetics encompasses nearly 100 years of research and culminated in the publication of the mouse genome sequence in 2002, from which the idea for this special issue arose. The issue features 37 peer-reviewed papers providing a wide-ranging overview of all major aspects of mouse genetics, from nuclear transfer and embryonic development to cancer, from reproduction to speciation and functional genomics technologies. Its aim is to present a suitable tool of investigation for the large population of researchers that use the mouse as a model animal. Covering a variety of topics, this publication will be a useful guide for scientists working in the fields of reproduction, development, evolution, cancer, toxicology, and cell biology as well as for beginners entering the world of mouse genetics.

Mouse Genetics

Mouse Genetics: Methods and Protocols provide selected mouse genetic techniques and their application in modeling varieties of human diseases.

Mouse Genetics

Mouse Genetics: Methods and Protocols provide selected mouse genetic techniques and their application in modeling varieties of human diseases. The chapters are mainly focused on the generation of different transgenic mice to accomplish the manipulation of genes of interest, tracing cell lineages and modeling human diseases. Composed in the highly successful Methods in Molecular Biology series format, each chapter contains a brief introduction, a list of necessary materials, systematic, readily reproducible methods and a notes section, which shares tips on troubleshooting in order to avoid known pitfalls. Comprehensive and authoritative, Mouse Genetics: Methods and Protocols promises to deliver fundamental techniques and protocols to geneticists, molecular biologists, cell and developmental biologists, students and postdoctoral fellows working in the various disciplines of mouse biology and modeling human disease.

The Mouse in Animal Genetics and Breeding Research

Use of the mouse was a logical choice in studying mammalian genetics, the
initial experiments being conducted by Cuénot in France and Castle in the United
States. Early research efforts in mouse genetics were directed toward problems
in ...

The Mouse in Animal Genetics and Breeding Research

The sequencing of the mouse genome has placed the mouse front and center as the most important mammalian genetics model. However, no recent volume has detailed the genetic contributions the mouse has made across the spectrum of the life sciences; this book aims to fill that vacuum. Mouse genetics research has made enormous contributions to the understanding of basic genetics, human genetics, and livestock genetics and breeding. The wide-ranging topics in the book include the mouse genome sequencing effort, molecular dissection of quantitative traits, embryo biotechnology, ENU mutagenesis, and genetics of disease resistance, and have been written by experts in their respective fields. Chapter 1: The Beginnings - Ode To A Wee Mouse (58 KB) Contents:The Beginnings: Ode to a Wee Mouse (E J Eisen)Testing Quantitative Genetic Selection Theory (E J Eisen)Maternal Effects, Genomic Imprinting and Evolution (J Funk-Keenan & W R Atchley)Inbreeding and Crossbreeding (G A Brockmann)Genotype by Environment Interaction: Lessons From the Mouse (W D Hohenboken)Genetics of Growth in the Mouse (J M Cheverud)Genetics of Body Composition and Metabolic Rate (L Bünger & W G Hill)Genetics of Reproduction (M K Nielsen)Genetics of Behavior (R J Hitzemann)Genetics of Disease Resistance (S L Ewart & R A Ramadas)Genomic Dissection of Complex Trait Predisposition (D Pomp)Mouse Mutagenesis (D R Beier)Embryo Biotechnologies (C A Pinkert & M J Martin)Transgenics (J D Murray & E A Maga)The Mouse in Biomedical Research (R B Roberts & D W Threadgill)The Mouse Genome Sequencing Project: An Overview (M C Wendl et al.) Readership: Researchers, teachers, graduate students and advanced undergraduates in genetics, genomics, biotechnology, bioinformatics, animal breeding and zoology. Key Features:Covers the methods used to find genes in the mouse that affect complex genetic traitsCuts across biomedical and bioagricultural applicationsNo competing titles availableKeywords:Genetics;Mouse;Biotechnology;Genome Sequencing;Quantitative Genetics;Transgenics;Growth;Reproduction;Biomedical Genetics;Biomedical Genetics;Behavior;Maternal Genetics;ENU Mutagenesis

Mouse Genetics and Transgenics

This unique book integrates knowledge from a wide range of expertise, specifically applied to the mouse and addressed at a wide audience from those new to the field to experts who want an update on the state of the art.

Mouse Genetics and Transgenics

This unique book integrates knowledge from a wide range of expertise, specifically applied to the mouse and addressed at a wide audience from those new to the field to experts who want an update on the state of the art. Mouse Genetics and Transgenics: A Practical Approach covers all aspects of using the mouse as a genetic model organism: care and husbandry; archiving stocks as frozen embryos or sperm; making new mutations by chemical mutagenesis; transgenesis; gene targeting; mapping mutations and polygenic traits by cytogenetic, genetic, and physical means; and disseminating and researching information via the Internet.

Mutagenesis of the Mouse Genome

We stand at an exciting crossroads in mouse genetics. The technology ... Large-
scale mouse mutagenesis is initiating discoveries that change our view of
mammalian genome functions while it produces many new models of human
disease.

Mutagenesis of the Mouse Genome

The Second Georgia Genetics Symposium was held color. Soon after, he joined the sta? of The Jackson in September 2000, and the development of this Laboratory in Bar Harbor, Maine. book took place over the nearly 4 years that ensued. Much of Bill’s research at the lab was centered During this time, many advances in the Genome around investigating phenotypic variability within Project and mouse mutagenesis were made. In the highly inbred strains, and in that connection he book overview, we discuss the development of the developed the technique of ovarian transplanta- Genome Project (which is the context for the sym- tion (even using embryonic donors) and a genetic posium), the role the mouse was playing at that scheme whereby graft compatibility could be time, how that role has evolved, and how the combined with the ability to distinguish o?spring chapters of the book address issues in mouse func- from donor and regenerated host ovaries. His tional genetics. Many of the chapters in this book work was in?uenced by the second World War, will provide useful resources for years to come. ?rst because The Jackson Laboratory turned into Of greater impact, our keynote speaker, the a production colony for the military, primarily to mutagenesis pioneer William L. (Bill) Russell, produce mice for typhoid testing, and secondly, passed away on July 23, 2003.

Advances in Genetics

These mouse families were the ancestors of many of the inbred strains that are
studied all over the world today. Although the American laboratories are
responsible for laying much of the foundations of mouse genetics, especially the
inbred ...

Advances in Genetics

Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. This volume of Advances in Genetics continues the series goal to present both human and molecular genetic reviews in a timely fashion. Anderson and Kay investigate CAB gene expression in the regulation of gene transcriptions in plants. Harmon and Allan offer a historical overview of apoptosis and its recent heightened interest. Developments involving four X-linked disorders and their resulting increased susceptibility to infection are presented by Smithand Notarangelo. Dickson and colleagues present research on the role of dystrophin in Duchenne muscular dystrophy and the potential feasibility of gene therapy in curing this disease as well as other diseases involving the heart and central nervous system. The relationship between mice and humans and the ways in which they help each other understand gene function and relationship is presented by Elizabeth Fisher. Timmons and Shearn summarize what information has been learned about prune, Killer of prune, and the prune/Killer of prune lethal interactions: rare genetic phenomena in Drosophila melanogaster. Meiotic recombination, via the breaking and rejoining of DNA and the subsequent reciprocal exchange and the cytological evidence of the exchange, are explored by Ross et al. Last, Coonar and McKenna discuss the four major cardiomyopathies, focusing on recent advances in hypertrophic cardiomyopathy.

Genetics of the Mouse

Genetics instructors will also find useful examples to illustrate undergraduate
biology courses. ... The establishment of highly detailed genetic maps was a
major and fundamental contribution to mouse geneticists during the twentieth
century ...

Genetics of the Mouse

This book, written by experienced geneticists, covers topics ranging from the natural history of the mouse species, its handling and reproduction in the laboratory, and its classical genetics and cytogenetics, to modern issues including the analysis of the transcriptome, the parental imprinting and X-chromosome inactivation. The strategies for creating all sorts of mutations, either by genetic engineering or by using mutagens, are also reviewed and discussed in detail. Finally, a last chapter outlines the methodology used for the analysis of complex or quantitative traits. The authors also discuss the importance of accurate phenotyping, which is now performed in the mouse clinics established worldwide and identify the limits of the mouse model, which under certain circumstances can fail to present the phenotype expected from the cognate condition in the human model. For each chapter an up-to-date list of pertinent references is provided. In short, this book offers an essential resource for all scientists who use or plan to use mice in their research.

Handbook of Genetics

Volume 4 Vertebrates of Genetic Interest Robert King. Dickie, M. M., 1966b
Mouse News Letter 35:31. Dickie, M. M. ... Duchen, L. W., 1970 Hereditary motor
end-plate disease in the mouse: Light and electron microscopic studies. J. Neurol
.

Handbook of Genetics

The purpose of the first four volumes of the Handbook of Genetics is to bring together collections of relatively short, authoritative essays or an notated compilations of data on topics of significance to geneticists. Many of the essays will deal with various aspects of the biology of certain species or species groups selected because they are favorite subjects for genetic investigation in nature or the laboratory. Often there will be an encyclo pedic amount of information available on such species, with new papers appearing daily. Most of these will be written for specialists in a jargon that is bewildering to a novice, and sometimes even to a veteran geneticist working with evolutionarily distant organisms. For such readers what is needed is a written introduction to the morphology, life cycle, reproductive behavior, and culture methods for the species in question. What are its particular advantages (and disadvantages) for genetic study, and what have we learned from it? Where are the classic papers, the key bibli ographies, and how does one get stocks of wild type or mutant strains? Lists giving the symbolism and descriptions for selected mutants that have been retained and are thus available for future studies are provided whenever possible. Genetic and cytological maps, mitotic karyotypes, and haploid DNA values are also included when available. Volume 4 deals with certain vertebrate species that have been studied in considerable detail from the standpoint of genetics or molecular cytogenetics. Such data are available for only a relatively few vertebrates.

Pathology of the Developing Mouse

Essentials of Mouse Genetics and Nomenclature Oded Foreman and Brad Bolon
CONTENTS Evolution.of.the.Mouse.as.a.Model.for.Research.....................................
.................................................14 Basic.Concepts.in.Laboratory.Mouse.Genetics.

Pathology of the Developing Mouse

Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).

Encyclopedia of Genetics

The Mouse t complex Genetic studies with mouse chimaeras Ethylnitrosourea (
ENU) as a genetic tool in mouse ... mouse as a model for the study of genetic
aspects of alcoholism Body weight limits in mice Introduction to Mouse Genetics
1.

Encyclopedia of Genetics

First Published in 2001. Routledge is an imprint of Taylor & Francis, an informa company.

Behavioral Genetics of the Mouse Genetics of behavioral phenotypes

"The first volume in the new Cambridge Handbooks in Behavioral Genetics, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically-modified or ...

Behavioral Genetics of the Mouse  Genetics of behavioral phenotypes

"The first volume in the new Cambridge Handbooks in Behavioral Genetics, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically-modified or pharmacologically-treated animals, and in the interpretation and analyses of the results obtained. Offering a comprehensive overview of the genetics of naturally-occurring variation in mouse behavior; from perception and spontaneous behaviors, such as exploration, aggression, social interactions and motor behaviors to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike"--

Behavioral Genetics of the Mouse

Behavioral Genetics ofthe Mouse: Volume II. Genetic Mouse Models
ofNeurobehavioral Disorders, eds. S. Pietropaolo, F. Sluyter, and W. E. Crusio.
Published by Cambridge University Press. C Cambridge University Press 2014.
Arnold, P.D. ...

Behavioral Genetics of the Mouse

A comprehensive and critical overview of the major genetically modified mouse lines used to model human neurobehavioral disorders.

Behavioral Genetics of the Mouse Volume 2 Genetic Mouse Models of Neurobehavioral Disorders

Behavioral Genetics ofthe Mouse: Volume II. Genetic Mouse Models
ofNeurobehavioral Disorders, eds. S. Pietropaolo, F. Sluyter, and W. E. Crusio.
Published by Cambridge University Press. C Cambridge University Press 2014.
Chapter ...

Behavioral Genetics of the Mouse  Volume 2  Genetic Mouse Models of Neurobehavioral Disorders

The second volume of Behavioral Genetics of the Mouse provides a comprehensive overview of the major genetically modified mouse lines used to model human neurobehavioral disorders; from disorders of perception, of autonomous and motor functions to social and cognitive syndromes, drug abuse and dependence as well as neurodegenerative pathologies. Mouse models obtained with different types of genetic manipulations (i.e. transgenic, knockout/in mice) are described in their pathological phenotypes, with a special emphasis on behavioral abnormalities. The major results obtained with many of the existing models are discussed in depth highlighting their strengths and limitations. A lasting reference, the thorough reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

The Genetics of the Mouse

The interaction of waved with the genes for hairlessness and Naked is dealt with
below ( see p . 81 ) . Wavéd - 2 Origin . This gene was first observed by KEELER
( 1935 ) in his “ abnormal corpus callosum ” stock of mice . Genetics . Waved - 2 ...

The Genetics of the Mouse


Microbial Status and Genetic Evaluation of Mice and Rats

Analysis. of. the. Mouse. Genome. Dabney K. Johnson, Donald A. Carpenter,
Cymbeline T. Culiat, Karen A. Goss, Mitchell L. Klebig, Edward J. Michaud, Darla
R. Miller, Liane B. Russell, Yun You, and Eugene M. Rinchik Mammalian
Genetics ...

Microbial Status and Genetic Evaluation of Mice and Rats

US/Japan meetings on laboratory animal science have been held virtually every year since 1980 under the US/Japan Cooperative Program on Science and Technology. Over the years these meetings have resulted in a number of important documents including the Manual of Microbiologic Monitoring of Laboratory Animals published in 1994 and the article Establishment and Preservation of Reference Inbred Strains of Rats for General Purposes. In addition to these publications, the meetings have been instrumental in increasing awareness of the need for microbiologic monitoring of laboratory rodents and the need for genetic definition and monitoring of mice and rats. In cooperation with the Comparative Medicine section of NCRR/NIH, the ILAR Council and staff are pleased to become the host for this important annual meeting and look forward to participating in future meetings. The support and sponsorship of NCRR (P40 RR 11611) in the United States and the Central Institute for Experimental Animals in Japan are gratefully acknowledged. Bringing together the leading scientists in the field of laboratory animal care has resulted in increased understanding of American and Japanese approaches to laboratory animal science and should continue to strengthen efforts to harmonize approaches aimed at resolving common challenges in the use of animal models for biomedical research and testing. This effort to improve understanding and cooperation between Japan and the United States should also be useful in developing similar interaction with other regions of the world including Europe, Australia, and Southeast Asia.

Encyclopedia of Behavioral Neuroscience

Mice The mouse has become the gold standard in animal studies of behavioral
genetics. Multiple factors have ... Human and mouse genes show a 99%
homology and a 96% conservation of syntenic regions. History of mouse genetics
The ...

Encyclopedia of Behavioral Neuroscience

Behavioral Neuroscientists study the behavior of animals and humans and the neurobiological and physiological processes that control it. Behavior is the ultimate function of the nervous system, and the study of it is very multidisciplinary. Disorders of behavior in humans touch millions of people’s lives significantly, and it is of paramount importance to understand pathological conditions such as addictions, anxiety, depression, schizophrenia, autism among others, in order to be able to develop new treatment possibilities. Encyclopedia of Behavioral Neuroscience is the first and only multi-volume reference to comprehensively cover the foundation knowledge in the field. This three volume work is edited by world renowned behavioral neuroscientists George F. Koob, The Scripps Research Institute, Michel Le Moal, Université Bordeaux, and Richard F. Thompson, University of Southern California and written by a premier selection of the leading scientists in their respective fields. Each section is edited by a specialist in the relevant area. The important research in all areas of Behavioral Neuroscience is covered in a total of 210 chapters on topics ranging from neuroethology and learning and memory, to behavioral disorders and psychiatric diseases. The only comprehensive Encyclopedia of Behavioral Neuroscience on the market Addresses all recent advances in the field Written and edited by an international group of leading researchers, truly representative of the behavioral neuroscience community Includes many entries on the advances in our knowledge of the neurobiological basis of complex behavioral, psychiatric, and neurological disorders Richly illustrated in full color Extensively cross referenced to serve as the go-to reference for students and researchers alike The online version features full searching, navigation, and linking functionality An essential resource for libraries serving neuroscientists, psychologists, neuropharmacologists, and psychiatrists

Behavioral Genetics of the Mouse Volume 1 Genetics of Behavioral Phenotypes

In recent years knowledge of the mouse genome and ready availability of
genetically manipulated mouse lines have further increased the focus of research
on mice, increasing their use vis-a-vis rats, the other most widely used subject
species ...

Behavioral Genetics of the Mouse  Volume 1  Genetics of Behavioral Phenotypes

The first volume in the new Cambridge Handbooks in Behavioral Genetics series, Behavioral Genetics of the Mouse provides baseline information on normal behaviors, essential in both the design of experiments using genetically modified or pharmacologically treated animals and in the interpretation and analyses of the results obtained. The book offers a comprehensive overview of the genetics of naturally occurring variation in mouse behavior, from perception and spontaneous behaviors such as exploration, aggression, social interactions and motor behaviors, to reinforced behaviors such as the different types of learning. Also included are numerous examples of potential experimental problems, which will aid and guide researchers trying to troubleshoot their own studies. A lasting reference, the thorough and comprehensive reviews offer an easy entrance into the extensive literature in this field, and will prove invaluable to students and specialists alike.

Genome Mapping and Genomics in Laboratory Animals

Mouse. Genome. Mapping. and. Genomics. P. Denny and C. Kole (eds.),
Genome Mapping and Genomics in ... Mice were the first mammals shown to
follow Mendel's laws of genetics (Cuenot 1902) and in the early twentieth century
were one ...

Genome Mapping and Genomics in Laboratory Animals

Mapping of animal genomes has generated huge databases and several new concepts and strategies, which are useful to elucidate origin, evolution and phylogeny. Genetic and physical maps of genomes further provide precise details on chromosomal location, function, expression and regulation of academically and economically important genes. The series Genome Mapping and Genomics in Animals provides comprehensive and up-to-date reviews on genomic research on a large variety of selected animal systems, contributed by leading scientists from around the world. Laboratory animals are those species that by accident of evolution, domestication and selective breeding are amenable to maintenance and study in a laboratory environment. Many of these species are studied as 'models' for the biology and pathology of humans. Laboratory animals included in this volume are sea-urchin, nematode worm, fruit fly, sea squirts, puffer fishes, medaka fish, African clawed frog, mouse and rat.