Semiconductor Nanomaterials

4.3 Multiplexed Imaging Using QDs 4.3.1 Multiplexed Cellular Imaging The application of QDs in cellular imaging has attracted much interest because of their unique optical properties and the possibility of multicolor imaging.

Semiconductor Nanomaterials

The book series Nanomaterials for the Life Sciences, provides an in-depth overview of all nanomaterial types and their uses in the life sciences. Each volume is dedicated to a specific material class and covers fundamentals, synthesis and characterization strategies, structure-property relationships and biomedical applications. The series brings nanomaterials to the Life Scientists and life science to the Materials Scientists so that synergies are seen and developed to the fullest. Written by international experts of various facets of this exciting field of research, the series is aimed at scientists of the following disciplines: biology, chemistry, materials science, physics, bioengineering, and medicine, together with cell biology, biomedical engineering, pharmaceutical chemistry, and toxicology, both in academia and fundamental research as well as in pharmaceutical companies. VOLUME 6 - Semiconductor Nanomaterials

Advances in Multimedia Information Processing PCM 2018

Originally, the shift-encoded multiplexed imaging system proposed in [16] requires at least L exposures if the FoV scene is divided into L channels. However, it cannot apply for dynamic scenarios. A brute-force solution is to limit the ...

Advances in Multimedia Information Processing     PCM 2018

The three-volume set LNCS 101164, 11165, and 11166 constitutes the refereed proceedings of the 19th Pacific-Rim Conference on Multimedia, PCM 2018, held in Hefei, China, in September 2018. The 209 regular papers presented together with 20 special session papers were carefully reviewed and selected from 452 submissions. The papers cover topics such as: multimedia content analysis; multimedia signal processing and communications; and multimedia applications and services.

Ternary Quantum Dots

/ZnS where PEGylated and peptide conjugated CuInS2 QDs have been used to demonstrate in vivo two-photon imaging. /ZnS and CuInSe2 7.5 Multiplex imaging Unlike organic fluorophores that can be excited only at specific wavelength, ...

Ternary Quantum Dots

Ternary Quantum Dots: Synthesis, Properties, and Applications reviews the latest advances in ternary (I-III-VI) chalcopyrite quantum dots (QDs), along with their synthesis, properties and applications. Sections address the fundamental key concepts of ternary quantum dots, progress in synthesis strategies (i.e., organic and aqueous synthesis), and characterization methods (i.e., transmission electron microscopy, dynamic light scattering, etc.). Properties of ternary quantum dots are comprehensively reviewed, including optical, chemical and physical properties. The factors and mechanisms of the cytotoxicity of ternary quantum dot-based nanomaterials are also described. Since ternary chalcopyrite quantum dots are less toxic and more environmentally benign than conventional binary II-VI chalcogenide quantum dots, they are being investigated to replace conventional quantum dots in a range of applications. Thus, this book reviews QDs in various applications, such as solar cells, photocatalytic, sensors and bio-applications. Reviews fundamental concepts of ternary quantum dots and quantum dot-nanocomposites including the most relevant synthesis strategies, key properties, and characterization techniques Delves into the cytotoxicity of quantum dots looking at the factors and mechanisms that influence cytotoxicity including demonstration of cytotoxicity assays for in vitro and in vivo tests Touches on the many applications of ternary quantum dots including biomedical applications, applications in solar cells, sensing applications, and photocatalytic applications

Engineering Technologies and Clinical Translation

Multiplex digital spatial profiling of proteins and RNA in fixed tissue. Nat Biotechnol 2020;38(5):586–99. ... Highly multiplexed imaging of tumor tissues with subcellular resolution by mass cytometry. Nat Methods 2014;11(4):417–22.

Engineering Technologies and Clinical Translation

Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy examines the challenges of delivering immuno-oncology therapies, focusing specifically on the development of solutions for drug delivery and its clinical outcomes. Immuno-oncology (IO) is a growing field of medicine at the interface of immunology and cancer biology leading to development of novel therapeutic approaches, such as chimeric antigen receptor T-cell (CAR-T) and immune checkpoint blockade antibodies, that are clinically approved approaches for cancer therapy. Although currently approved IO approaches have shown tremendous promise for select types of cancers, broad application of IO strategies could even further improve the clinical success, especially for diseases such as pancreatic cancer, brain tumors where the success of IO so far has been limited. This volume of Delivery Strategies and Engineering Technologies in Cancer Immunotherapy discusses biomaterial, microfluidic, and biodegradable devices, engineered microbes, personalized medicine, clinical approval process, and many other IO technologies. Engineering Technologies and Clinical Translation: Volume 3: Delivery Strategies and Engineering Technologies in Cancer Immunotherapy creates a comprehensive treaty that engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side. Explores engineering technologies and their clinical translation in a comprehensive way Presents forecasting on the future of nanotechnology and drug delivery for IO Engages the scientific and medical community who are involved in the challenges of immunology, cancer biology, and therapeutics with possible solutions from the nanotechnology and drug delivery side

World Scientific Reference On Plasmonic Nanomaterials Principles Design And Bio applications In 5 Volumes

... 489 multimodality imaging, 443 multimode fibers, 471 multimode imaging, 422, 433 multiplexed, 481 multiplexed cellular imaging, 459 multiplexed detection, 221 multiplexed imaging of breast cancer cell phenotypes, 282 multiplexed ...

World Scientific Reference On Plasmonic Nanomaterials  Principles  Design And Bio applications  In 5 Volumes

World Scientific Reference on Plasmonic Nanomaterials: Principles, Design and Bio-applications is a book collection that encompasses multiple aspects of the exciting and timely field of nanoplasmonics, under the coordination of international plasmonic nanomaterials expert, Dr Luis Liz-Marzán. Plasmonics has a long history, from stained glass in ancient cathedrals, through pioneering investigations by Michael Faraday, all the way into the nanotechnology era, where it blossomed into an extremely active field of research with potential applications in a wide variety of technologies.Given the breadth of the materials, phenomena and applications related to plasmonics, this Reference Set offers a collection of chapters within dedicated volumes, focusing on the description of selected phenomena, with an emphasis in chemistry as an enabling tool for the fabrication of, often sophisticated, plasmonic nanoarchitectures and biomedicine as the target application.Basic principles of surface plasmon resonances are described, as well as those mechanisms related to related phenomena such as surface-enhanced spectroscopies or plasmonic chirality. Under the guidance of theoretical models, wet chemistry methods have been implemented toward the synthesis of a wide variety of nanoparticles with different compositions and tailored morphology. But often the optimal nanoarchitecture requires post-synthesis treatments, including functionalization of nanoparticle surfaces, application of external stimuli toward self-assembly into well-defined supraparticle structures and so-called supercrystals. All such nanomaterials can find applications in various biomedical aspects, most often in relation to diagnosis, through either the detection of disease biomarkers at extremely low concentrations or the design of bioimaging methods for in vivo monitoring. Additionally, novel therapeutic tools can also profit from plasmonic nanomaterials, such as photothermal therapy or nanocatalysis.The reference set thus offers comprehensive information of an extremely active subset within the world of plasmonic nanomaterials and their applications, which aims at not just collecting existing knowledge but also promoting further research and technology transfer into the market and the clinic.

Phosphor Handbook

temporal lifetime, thus the UC in vivo multiplexed bioimaging can be easily a ieved. Note here, these optical parameters can not only work by themselves to be multiplexing encoders but also ally with ea other to remarkably enri the ...

Phosphor Handbook

A benchmark publication, the first edition of the Phosphor Handbook, published in 1998, set the standard for references in the field. The second edition, updated and published in 2007, began exploring new and emerging fields. However, in the last 14 years, since the second edition was published, many notable advances and broader phosphor applications have occurred. Completely revised, updated, and expanded into three separate volumes, this third edition of the Handbook covers the most recent developments in phosphor research, characterization, and applications. This volume on ‘Novel Phosphors, Synthesis, and Applications’ provides the descriptions of synthesis and optical properties of phosphors used in different applications, including the novel phosphors for some newly developed applications. The chapters in this book cover: Various LED-based phosphors and their synthesis and applications Ingenious integrated smart phosphors and their novel optoelectronic and photonic devices Quantum dot, single crystalline, and glass phosphors Upconversion nanoparticles for super-resolution imaging and photonic and biological applications Special phosphors for laser, OLED, energy storage, quantum cutting, thermometry, photosynthesis, AC-driven LED, and solar cells

Multiplex Immunohistochemistry Immunofluorescence Technique The Potential and Promise for Clinical Application

Validating Whole Slide Imaging Systems for Diagnostic Purposes in Pathology: Guideline Update from the College of American Pathologists in Collaboration ... Deep Profiling of Mouse Splenic Architecture with CODEX Multiplexed Imaging.

Multiplex Immunohistochemistry Immunofluorescence Technique  The Potential and Promise for Clinical Application


Tumor Immunology and Immunotherapy Integrated Methods Part A

As such, multiple imaging platforms have emerged that enable multiplexed monitoring of 7–60 biomarkers in tissue sections; however, the high cost of reagents and imaging instrumentation severely limit broad use for routine analyses ...

Tumor Immunology and Immunotherapy   Integrated Methods Part A

Tumor Immunology and Immunotherapy Integrated Methods - Part A, Volume 635 in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Specific chapters to this release include Deconvolution of the immunological contexture of mouse tumors with multiplexed immunohistochemistry, High-dimensional multiplexed immunohistochemical characterization of immune contexture in human cancers, Multiplex assay by IHC for melanoma tumor microenvironment evaluation, Characterization of the tumor immune microenvironment by multispectral image analysis of multiplex immunofluorescence images, Phenotyping of immune cells in situ using multispectral imaging quantification, and much more. Authored by leaders in the field of enzymology Provides a comprehensiveness level of discussion on the field Presents a highly specialized group of topics that delve deep into new updates and future prospects

Biomaterials for Cancer Therapeutics

Multimodal imaging or multiplexed imaging refers to simultaneous production of signals for more than one imaging technique. For example, one could combine using optical, magnetic, and radioactive reporters to be detected by SPECT, MRI, ...

Biomaterials for Cancer Therapeutics

Cancer can affect people of all ages, and approximately one in three people are estimated to be diagnosed with cancer during their lifetime. Extensive research is being undertaken by many different institutions to explore potential new therapeutics, and biomaterials technology is now being developed to target, treat and prevent cancer. This unique book discusses the role and potential of biomaterials in treating this prevalent disease. The first part of the book discusses the fundamentals of biomaterials for cancer therapeutics. Chapters in part two discuss synthetic vaccines, proteins and polymers for cancer therapeutics. Part three focusses on theranosis and drug delivery systems, whilst the final set of chapters look at biomaterial therapies and cancer cell interaction. This extensive book provides a complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer. Biomaterials for cancer therapeutics is an essential text for academics, scientists and researchers within the biomedical industry, and will also be of interest to clinicians with a research interest in cancer therapies and biomaterials. A complete overview of the latest research into the potential of biomaterials for the diagnosis, therapy and prevention of cancer Discusses the fundamentals of biomaterials for cancer therapeutics Discusses synthetic vaccines, proteins and polymers for cancer therapeutics

Adverse Effects of Engineered Nanomaterials

(B) Demonstration of deep-tissue multiplexed imaging 24 h after i.v. injection of five unique SERS nanoparticle batches simultaneously. (a) Graph depicting five unique Raman spectra, each associated with its own SERS batch: S420 (red), ...

Adverse Effects of Engineered Nanomaterials

An essential reference that discusses occupational exposure and the adverse health effects of engineered nanomaterials and highlights current and future biomedical applications of these nanomaterials in relation to nanosafety. Multi-authored book written by leading US and European experts on nanotoxicology and nanomedicine Discusses the health implications and a clinical translation of experimental data in this area Takes a schematic, non-exhaustive approach to summarize the most important research data in this field Includes a glossary, with a brief explanation of the term and with a reference to where the term or phrase has been used will be included within the book

Resource Efficient Medical Image Analysis

The rapid development of multiplexed imaging techniques such as multiplexed immunohistochemistry (mIHC), multiplexed immunofluorescence and imaging mass cytometry has enabled the spatial distribution of transcripts and proteins to be ...

Resource Efficient Medical Image Analysis

This book constitutes the refereed proceedings of the first MICCAI Workshop on Resource-Efficient Medical Image Analysis, REMIA 2022, held in conjunction with MICCAI 2022, in September 2022 as a hybrid event. REMIA 2022 accepted 13 papers from the 19 submissions received. The workshop aims at creating a discussion on the issues for practical applications of medical imaging systems with data, label and hardware limitations.

Nanotheranostics for Cancer Applications

Development of QD-based multiplexed imaging has enormous potential for revealing the interactions of different molecules simultaneously [119]. Based on QD imaging on collagen IV, various patterns of tumor invasion have been identified ...

Nanotheranostics for Cancer Applications

This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.

Hybrid Nanomaterials

imaging (e.g., elegans, mice and zebrafish) is also obtained using hybrid UCNPs due to their intrinsic multiplexed imaging and deep tissue penetration. Since the precursory work of UCL imaging in live elegans by Lim et al. (Lim et al.

Hybrid Nanomaterials

Over the last decade, an unprecedented expansion in the field of nanomedicine has resulted in the development of new nanomaterials for diagnosis and therapy of various diseases such as cancer. This book covers the design, synthesis and applications of various functionally-hybridized nanomaterials for biomedical applications. It includes strategies for design and synthesis of hybrid nanomaterials, surface engineering of various nanoparticle-based hybrid nanosystems for cancer imaging and therapy, toxicity aspects of nanomaterials and the challenges in translation research of hybrid nanomaterials.

Translational Cardiology

Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques Cam Patterson, ... translational, multiplexed imaging, trace amount (ng) of probe needed High sensitivity, high throughput, easy, ...

Translational Cardiology

Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques provides an up-to-date introduction to the role circadian rhythms, cardiac plasticity, and mechanotransduction play in the heart, while at the same time introducing new developments in cellular, viral, and non-biologic therapies that are in the process of being developed. Importantly, the focus of this book is on topics that, due to their novelty, are largely not covered in the other major textbooks. A special emphasis is placed on the molecular basis of cardiac metabolism, new concepts in cardiac remodeling, and translational therapies and imaging techniques currently under development for clinical use. The chapters are written by experts from diverse clinical and biomedical research backgrounds. Translational Cardiology: Molecular Basis of Cardiac Metabolism, Cardiac Remodeling, Translational Therapies and Imaging Techniques simplifies the complexity of the molecular basis of disease by focusing on patient-oriented disease mechanisms and therapies and is of great value to a broad audience including physicians (e.g. cardiologists, cardiovascular surgeons, pathologists) as well as translational biomedical researchers in a wide range of disciplines.

Nanomedicine for Deep Tissue High Resolution Bio Imaging and Non Invasive Therapy

... fluorescence/dual bioluminescence multiplexed imaging for in vivo visualizing the location, survival, and differentiation of transplanted stem cells. Adv. Funct. Mater. 29:1806546. doi: 10.1002/adfm.201806546 Iwano, S., Obata, R., ...

Nanomedicine for Deep Tissue High Resolution Bio Imaging and Non Invasive Therapy

Dr Ming-Yuan Wei currently holds a pending U.S. Patent Application entitled “Systems and Methods for High-Resolution Imaging”. All other Guest Editors have no other competing interests to declare with regards to the Topic subject.

Targeted Cancer Imaging

Unlike organic dyes, QDs can allow for multiplexed imaging due to the narrow-band emissions. Development of a protease-activatable QD (PbS/CdS/ZnS core/shell/shell) probe emitting in the NIR-II spectral region (PA-NIRQD) showed ...

Targeted Cancer Imaging

Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology reviews and categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches that involve membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells, all with the goal of pointing the way to developing precise targeting and multifunctional nanotechnology-based imaging probes in the future. This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, and thus making it suitable for researchers ranging from oncology to bioengineering. Although considerable efforts have been conducted to diagnose, improve and treat cancer in the past few decades, existing therapeutic options are insufficient, as mortality and morbidity rates remain high. One of the best hopes for substantial improvement lies in early detection. Recent advances in nanotechnology are expected to increase our current understanding of tumor biology, allowing nanomaterials to be used for targeting and imaging both in vitro and in vivo experimental models. Gives understanding of cancer biology that is appropriate for students and researchers in engineering and nanotechnology Demonstrates cancer targeting strategies of multifunctional nanotechnology-based imaging probes Shows how to design, synthesize and apply cancer imaging nanostructures

Molecular Imaging in Oncology

Bioconju- gated QDs have raised new possibilities for ultrasensitive and multiplexed imaging of molecular targets in living cells, animal models, and possibly in humans. The use of QDs for sensitive and multicolor cellular imaging has ...

Molecular Imaging in Oncology

With molecular imaging becoming one the fastest growing topics in medical schools, Informa Healthcare presents Molecular Imaging in Oncology, the first comprehensive reference on molecular imaging in oncology.Giving clinicians and researchers a greater understanding of the current field, this text covers:instrumentation and techniquescancer imaging

Optical Compressive Imaging

Image and depth from a conventional camera with a coded aperture. ACM Trans. Graph., 26(3), 70:1–70:9. Horisaki, R. and Tanida, J. (2010). Multi-channel data acquisition using multiplexed imaging with spatial encoding.

Optical Compressive Imaging

This dedicated overview of optical compressive imaging addresses implementation aspects of the revolutionary theory of compressive sensing (CS) in the field of optical imaging and sensing. It overviews the technological opportunities and challenges involved in optical design and implementation, from basic theory to optical architectures and systems for compressive imaging in various spectral regimes, spectral and hyperspectral imaging, polarimetric sensing, three-dimensional imaging, super-resolution imaging, lens-free, on-chip microscopy, and phase sensing and retrieval. The reader will gain a complete introduction to theory, experiment, and practical use for reducing hardware, shortening image scanning time, and improving image resolution as well as other performance parameters. Optics practitioners and optical system designers, electrical and optical engineers, mathematicians, and signal processing professionals will all find the book a unique trove of information and practical guidance. Delivers the first book on compressed sensing dealing with system development for a wide variety of optical imaging and sensing applications. Covers the fundamentals of CS theory, including noise and algorithms, as well as basic design approaches for data acquisition in optics. Addresses the challenges of implementing compressed sensing theory in the context of different optical imaging designs, from 3D imaging to tomography and microscopy. Provides an essential resource for the design of new and improved devices with improved image quality and shorter acquisition times. Adrian Stern, PhD, is associate professor and head of the Electro-Optical Engineering Unit at Ben-Gurion University of the Negev, Israel. He is an elected Fellow of SPIE.

Nanobiomaterials in Medical Imaging

The narrow emission and broad absorption spectra of QDs make them well suited to multiplexed imaging, in which multiple colors and intensities are combined to encode genes, proteins, and small-molecule libraries (Jamiesona et al., ...

Nanobiomaterials in Medical Imaging

Nanobiomaterials in Medical Imaging presents the latest developments in medical exploratory approaches using nanotechnology. Leading researchers from around the world discuss recent progress and state-of-the-art techniques. The book covers synthesis and surface modification of multimodal imaging agents, popular examples of nanoparticles and their applications in different imaging techniques, and combinatorial therapy for the development of multifunctional nanocarriers. The advantages and potential of current techniques are also considered. This book will be of interest to postdoctoral researchers, professors and students engaged in the fields of materials science, biotechnology and applied chemistry. It will also be highly valuable to those working in industry, including pharmaceutics and biotechnology companies, medical researchers, biomedical engineers and advanced clinicians. A valuable resource for researchers, practitioners and students working in biomedical, biotechnological and engineering fields A detailed guide to recent scientific progress, along with the latest application methods Presents innovative opportunities and ideas for developing or improving technologies in nanomedicine and medical imaging

Fundamentals of Diagnostic Radiology

Multiplexed imaging in cancer diagnosis: applications and future advances. Lancet Oncol 2010;11:589–595. Lee S, Xie J, Chen X. Peptide-based probes for targeted molecular imaging. Biochemistry 2010;49:1364–1376. Libby P, DiCarli M, ...

Fundamentals of Diagnostic Radiology

This fully revised edition of Fundamentals of Diagnostic Radiology conveys the essential knowledge needed to understand the clinical application of imaging technologies. An ideal tool for all radiology residents and students, it covers all subspecialty areas and current imaging modalities as utilized in neuroradiology, chest, breast, abdominal, musculoskeletal imaging, ultrasound, pediatric imaging, interventional techniques and nuclear radiology. New and expanded topics in this edition include use of diffustion-weighted MR, new contrast agents, breast MR, and current guidelines for biopsy and intervention. Many new images, expanded content, and full-color throughout make the fourth edition of this classic text a comprehensive review that is ideal as a first reader for beginning residents, a reference during rotations, and a vital resource when preparing for the American Board of Radiology examinations. More than just a book, the fourth edition is a complete print and online package. Readers will also have access to fully searchable content from the book, a downloadable image bank containing all images from the text, and study guides for each chapter that outline the key points for every image and table in an accessible format—ideal for study and review. This is the 1 volume set.