Neurotransmitter changes taking place in the brain of patients with dementia disorders, mainly Alzheimer type dementia, are reported.
Author: C.G. Gottfries
Publisher: Springer Science & Business Media
Neurotransmitter changes taking place in the brain of patients with dementia disorders, mainly Alzheimer type dementia, are reported. Their role in the pathogenesis of Alzheimer's disease is discussed; and the neurochemical changes are considered as a base for formulating treatment strategies. By studying markers in the cerebrospinal fluid, diagnostic methods may be achieved that will aid in diagnosing subgroups of dememtia.
It also, includes numerous illustrations and schematic diagrams. This book aims to cover the role of neurotransmitters, the substances released form neurons to act on neurons.
Author: Roy Webster
Publisher: John Wiley & Sons
Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.
Understanding the neurotransmitters : key to the workings of the brain / W.
Birkmayer, ... Supplementum, ISSN 0303-6995 ; 30) Based on the Symposium “ Neurotransmitter and Dementia" held during the Fourth Congress of the
First multi-year cumulation covers six years: 1965-70.
A series of human clinical trials have been launched to investigate the efficacy of
memantine for the treatment of Alzheimer's disease, vascular dementia, HIV-
associated dementia, diabetic neuropathic pain, as well as glaucoma. Some of ...
Author: Yoshimi Misu
Publisher: CRC Press
New research suggests it is highly probable that DOPA, in addition to being a precursor to dopamine, functions by itself as a neurotramsmitter and/or neuromodulator. Neurobiology of DOPA as a Neurotransmitter integrates background information about DOPA as an inert amino acid precursor of dopamine with the evidence showing that DOPA fulfills several criteria of neurotransmitters. Providing easy access to, and complete understanding of, the latest research on the subject, the book makes the case that DOPA meets many of the criteria of neurotransmitters and includes anti-evidence in some instances. The book begins with a historical review of current knowledge of DOPA. It characterizes DOPA as a prominent example showing transmutation from an inert substance to a gold drug in Parkinson's disease and further to a neurotransmitter in its own right. The next chapters cover the essential criteria of a neurotransmitter such as synthesis, existence, and competitive antagonism. The book describes metabolism composed of catecholamine synthesis and degradation products related to neuron death, physiological release of DOPA in the lower brainstem, striatum, and nucleus accumbens, and physiological or pharmacological responses involved in baroreflex neurotransmission and related to behavioral science including interactions with catecholamines, acetylcholine, glutamate, and GABA. The book explores recognition sites, transport sites, and therapeutic role and mechanisms for neuron death related to adverse influence in the treatment of Parkinson's Disease. Edited by experts in the field, the breadth and depth of information contained in this book is confirmed by a quick scan of the chapter authors. They summarize the issues surrounding DOPA neurotoxicity and explore the link between experimental studies and clinical relevance.
Release on 1983 | by Committee on Science, Engineering, and Public Policy (U.S.)
For some neurotransmitter substances , the precursor chemicals as well as the
intermediate stages of chemical ... Senile dementia is a condition of profound
intellectual decline and personality change that occurs in some persons as they
Author: Committee on Science, Engineering, and Public Policy (U.S.)
No system works alone. The chapters in this book explicitly examine the interactions of neurotransmitter systems involved in the regulation of cognitive processes.
Publisher: Springer Science & Business Media
JAMES L. MCGAUGH Understanding of the nature and functions of neurotransmitter systems in the brain has increased enormously in recent decades. Lack of knowledge required us, not too long ago, to use the adjective "putative" when discussing transmitters. Such caution is no longer essential (at least for a number of transmitters). Impressive progress has been achieved in understanding the pharmacology, biochemistry and anatomy of transmitter systems. There has, however, been relatively less progress in understanding the functioning of brain transmitters in regulating and mediating behavior. A simple and certainly correct explanation for this is, of course, that understanding of neurotransmitter functions requires prior detailed knowledge of basic pharmacology, biochemistry and anatomy. Beyond that, it now seems likely that progress in understanding the functions of brain neurotransmitters will proceed only as we examine the interactions of neurotransmitter systems in regulating behavioral functions. This premise is, of course, suggested by the findings of studies of the chemical neuroanatomy of the brain: Neurotransmitter systems are influenced by other neurotransmitter systems and, in tum, influence the same as well as other systems. No system works alone. The chapters in this book explicitly examine the interactions of neurotransmitter systems involved in the regulation of cognitive processes. The facts and interpretations offered provide compelling support for the premise that cognitive processes are orchestrated by interactions among neurotransmitter systems. And, they offer promise that understanding of such interactions will be of critical importance in the develop ment of treatments for brain diseases affecting cognitive functioning.
To compensate for the loss the neurotransmitter turnover is enhanced , as
evidenced by increased metabolite / neurotransmitter ratios . In Alzheimer ' s
disease and senile dementia of Alzheimer type , the reduction of several neurotransmitter ...
There are in addition changes in neuro - transmitter receptors which may reflect
post - synaptic cell damage , but ... Journal of Neurochemistry 38 : 1781 - 1784
Davies P 1979 Neurotransmitter - related enzymes in senile dementia of the ...
Neurotransmitters Neurotransmitter concentrations change after stroke as a result
of a decrease in cerebral blood flow . ... in neurotransmitter concentrations in the
serum and cerebrospinal fluid of patients with multi - infarct dementia or senile ...
This type of research has been driven by the assumption that the neurochemical
deficits in Alzheimer's disease result primarily from biochemical abnormalities in
the synthesis or release of the neurotransmitter acetylcholine; it is assumed that ...
This does , of course , not exclude a further study of the neurotransmitter
disturbances as they have pathogenetic importance for dementia symptoms and
offer possibilities for treatment hypotheses . REFERENCES 1 . Alzheimer , A. (
1907 ) .
Release on 1986 | by WHO Scientific Group on Senile Dementia
Monoamine metabolism in senile dementia of Alzheimertype . Journal of
neurological science , 60 : 383–392 ( 1983 ) . 33. Cross , A.J. ET AL . Studies on neurotransmitter receptor systems in neocortex and hippocampus in senile dementia of ...