Certain mutations may lead to cancer or other diseases. This book gathers together and presents the latest research in this field.
Author: Charles L. Valon
Publisher: Nova Publishers
Mutation refers to any change in the DNA of a cell. Mutations may be caused by mistakes during cell division, or they may be caused by exposure to DNA-damaging agents in the environment. Mutations can be harmful, beneficial, or have no effect. If they occur in cells that make eggs or sperm, they can be inherited; if mutations occur in other types of cells, they are not inherited. Certain mutations may lead to cancer or other diseases. This book gathers together and presents the latest research in this field.
[ 92 ] Ridker , P.M. , et al . , Mutation in the gene coding for coagulation factor V and the risk of myocardial ... is not a risk factor for arterial vascular disease in the elderly : results from the Cardiovascular Health Study .
Author: Garret D. Ruper
Publisher: Nova Publishers
A stroke occurs when the blood supply to the part of the brain is suddenly interrupted (ischemic) or when a blood vessel in the brain bursts, spilling blood into the spaces surrounding the brain cells (haemorrhagic). Generally, there are three treatment stages for stroke: prevention, therapy immediately after stroke, and post-stroke rehabilitation. Therapies to prevent stroke are based on treating an individual's underlying risk factors. This book includes within its scope the prevention, risk factors, symptoms, diagnosis, treatment, and rehabilitation of stroke. Leading-edge scientific research from throughout the world is presented.
Over - expression of catalytically inactive SHP - 2 mutant inhibits the Ras - Erk pathway , even though the direct ... However , a recent study has demonstrated that Grb2 binding is not sufficient to mediate the signaling function of ...
Author: Paul Jackson
Publisher: Nova Publishers
The spread of cancer cells from their organ of origin to distant tissues is called metastasis. Cancer metastasis is the main cause of death from cancer, and in many cases is difficult to detect or treat. The process by which tumour cells become metastatic is complex and involves many stages, including detachment of cells from the main tumour mass, degradation of the surrounding extra-cellular matrix, invasion into nearby blood vessels, travel and survival through the circulatory system, attachment to a vessel wall, extra-vasation, degradation of the extra-cellular matrix into a distant tissue/organ, and the development of a novel blood supply. In order to accomplish this process, the cells acquire characteristics which are important for each stage. Recently, a class of genes known as metastasis suppressors' has been the subject of intense investigation. For some metastasis suppressor genes, there is strong evidence from both in vitro and in vivo studies to demonstrate key roles in the metastatic process, for others data is much more limited, and their importance uncertain. In this book, chapters are devoted to providing up-to-date summaries of our understanding of individual metastasis suppressor genes. Each is written by a leading authority in the study of that gene. Topics covered include discussions on how each metastasis suppressor was discovered, the mechanisms underlying their loss of expression in tumours and tumour cell lines, their proposed molecular functions, and the consequences to a tumour cell of the loss of this function. This compilation aims to provide, in a single volume, comprehensive information that will be valuable to all scientists working in cancer research, to students needing to understand molecular events that regulate tumour progression and the acquisition of metastasis, and to clinicians who might wish to know more of the roles of potentially new markers for cancer diagnosis and prognosis.
This research progress has resulted in many experimental treatments and cures which establish hope for wide - spread cures . This new book brings together important research from around the world in this frontal field .
Author: Lee P. Jeffries
Publisher: Nova Publishers
Cancer is a group of different diseases (over 100) characterised by uncontrolled growth and spread of abnormal cells. Cancer can arise in many sites and behave differently depending on its organ of origin. If a cancer spreads (metastasizes), the new tumour bears the same name as the original (primary) tumour. Significant progress has been made in recent years in the battle against cancer and in understanding its underlying biological mechanisms. This research progress has resulted in many experimental treatments and cures which establish hope for wide-spread cures. The book brings together important research from around the world in this frontal field.
Advances in vector research have resulted in recombinant lentiviruses , with large fragments of the human B - globin gene , the site of the sickle mutation that needs to be corrected . Recently , Pawliuk and colleagues demonstrated in ...
One interesting point to explain the cases with overexpression of p53 but without gene alterations is that the accumulation of the protein may be caused by factors other than mutation , and several viruses use common strategies of ...
Author: Constantine S. Umar
Publisher: Nova Publishers
Epstein-Barr virus, frequently referred to as EBV, is a member of the herpes virus family and one of the most common human viruses. The virus occurs world-wide, and most people become infected with EBV sometime during their lives. In the United States, as many as 95 per cent of adults between 35 and 40 years of age have been infected. Infants become susceptible to EBV as soon as maternal antibody protection (present at birth) disappears. Many children become infected with EBV, and these infections usually cause no symptoms or are indistinguishable from the other mild, brief illnesses of childhood. In the United States and in other developed countries, many persons are not infected with EBV in their childhood years. When infection with EBV occurs during adolescence or young adulthood, it causes infectious mononucleosis 35 per cent to 50 per cent of the time. EBV also establishes a lifelong dormant infection in some cells of the body's immune system. A late event in a very few carriers of this virus is the emergence of Burkitt's lymphoma and nasopharyngeal carcinoma. This new book presents leading research from around the world in this field.
Release on 1993 | by United States. Dept. of Energy. Office of Health and Environmental Research
FY 1992 : Summaries of Projects Sponsored by the Office of Health and Environmental Research United States. ... in vivo somatic cell mutations utilizing new developments in cytochemistry , analytical cytology , and molecular biology .
Author: United States. Dept. of Energy. Office of Health and Environmental Research
“New developments in the USDA and state experiment station sunflower breeding programs,” in Proceedings of the 4th International Sunflower Conference, Memphis, TN, 181–183. ... The Pervenets high oleic mutation: methodological studies.
Release on 1993 | by United States. Department of Energy. Office of Health and Environmental Research
Summaries of Projects Sponsored by the Office of Health and Environmental Research United States. ... human in vivo somatic cell mutations utilizing new developments in cytochemistry , analytical cytology , and molecular biology .
Author: United States. Department of Energy. Office of Health and Environmental Research
New developments in mutation research. New York: Nova Publishers; 2007.  Waters MD. Short-term bioassays in the analysis of complex environmental mixtures III. Environmental science research, vol. 27. New York: Springer; 2012.
Author: Ashutosh Kumar
Publisher: Academic Press
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation. By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation. Presents an up-to-date and in-depth review of the current state of mutagenesis research Draws upon the combined experience and expertise of an international group of highly respected editors and chapter authors Provides an introduction to the concept of mutagenesis with particular consideration given to novel chemicals and materials
12.0432 , JTU MUTAGENESIS BY CARCINOGENS - A MOLECULAR APPROACH M.Z. Humayun , College of Medicine & Dentistry of New Jersey , New Jersey Medical School , School of Medicine , Dept. of Microbiology , 100 Bergen St. , Newark , New Jersey ...
In the majority of the research projects, mutation was used as an indicator of test effectiveness. However, recently researchers have also focused on a different ... During these years there are many new developments, applications, ...
Publisher: Academic Press
Advances in Computers, Volume 112, the latest volume in a series published since 1960, presents detailed coverage of innovations in computer hardware, software, theory, design and applications. Chapters in this updated volume include Mobile Application Quality Assurance, Advances in Combinatorial Testing, Advances in Applications of Object Constraint Language for Software Engineering, Advances in Techniques for Test Prioritization, Data Warehouse Testing, Mutation Testing Advances: An Analysis and Survey, Event-Based Concurrency: Applications, Abstractions, and Analyses, and A Taxonomy of Software Integrity Protection Techniques. Provides in-depth surveys and tutorials on new computer technology Covers well-known authors and researchers in the field Presents extensive bibliographies with most chapters Includes volumes that are devoted to single themes or subfields of computer science
From Basic Research to Applications OECD. Mutations affecting type X collagen ... Future developments New developments in the transgenic technologies make it possible to modify transgenes in vivo for production of new disease models.
Publisher: OECD Publishing
This proceedings brings together scientific papers covering the breadth and significance of model animals used in scientific research, and scientific and policy summaries based on workshop discussions.
There is a question of balance: What are the marginal benefits of redirecting some research funding away from traditional biomedical research and towards epidemiological and service development research? Redirection alone is not enough ...
Author: Kate Irving
New Developments in Dementia Prevention Research addresses a dearth of knowledge about dementia prevention and shows the importance of considering the broader social impact of certain risk factors, including the role we each play in our own cognitive health throughout the lifespan. The book draws on primary and secondary research in order to investigate the relationship between modifiable factors, including vascular and psychosocial risks, that may affect the incidence of dementia. Bringing together world-leading expertise from applied science, medicine, psychology, health promotion, epidemiology, health economics, social policy and primary care, the book compares and contrasts scientific and service developments across a range of settings. Each chapter presents these themes in a way that will ensure best practice and further research in the field of dementia prevention is disseminated successfully throughout the world. Perhaps most importantly, chapters also question what type of social responsibility we are prepared to embrace in order to address the challenges inherent in dementia prevalence. New Developments in Dementia Prevention Research includes contributions from leading authorities in brain health and dementia prevention and provides an essential contribution to the discourse on dementia prevention. It will be of great interest to academics, researchers and postgraduate students engaged in the study of the psychological and social aspects of aging and dementia.
New Drug Development: A Regulatory Overview. ... Guidelines for Reproduction Studies for Safety Evaluation of Drugs for Human Use. ... Editorial: In vivo Assessment of Pig-a Gene Mutation e Recent Developments and Assay Validation.
Author: Ali S. Faqi
Publisher: Academic Press
A Comprehensive Guide to Toxicology in Preclinical Drug Development is a resource for toxicologists in industry and regulatory settings, as well as directors working in contract resource organizations, who need a thorough understanding of the drug development process. Incorporating real-life case studies and examples, the book is a practical guide that outlines day-to-day activities and experiences in preclinical toxicology. This multi-contributed reference provides a detailed picture of the complex and highly interrelated activities of preclinical toxicology in both small molecules and biologics. The book discusses discovery toxicology and the international guidelines for safety evaluation, and presents traditional and nontraditional toxicology models. Chapters cover development of vaccines, oncology drugs, botanic drugs, monoclonal antibodies, and more, as well as study development and personnel, the role of imaging in preclinical evaluation, and supporting materials for IND applications. By incorporating the latest research in this area and featuring practical scenarios, this reference is a complete and actionable guide to all aspects of preclinical drug testing. Chapters written by world-renowned contributors who are experts in their fields Includes the latest research in preclinical drug testing and international guidelines Covers preclinical toxicology in small molecules and biologics in one single source
Release on 2020-12-14 | by Intergovernmental Oceanographic Commission
Mutation Research/Reviews in Mutation Research, Vol. 589, No. 1, pp. 31–45. Moed, H. F. 2009. New developments in the use of citation analysis in research evaluation. Archivum Immunologiae et Therapiae Experimentalis, Vol.
Olson (98) likens the current situation in mutation research to the status of computer technology in the late 1950s, ... characteristics of current research in molecular genetics is the rapid pace of new developments and ideas; ...
Release on 2009-07-07 | by Great Britain: Parliament: House of Lords: Science and Technology Committee
New developments 2.4 In 2007 , Professor Doug Easton and colleagues , published a study in Nature outlining the discovery of five new low penetrance genes thought to be involved in breast cancer development . The study compared the ...
Author: Great Britain: Parliament: House of Lords: Science and Technology Committee
Publisher: The Stationery Office
Category: Political Science
Volume 1 Report also available (ISBN 9780108444517). Genomic medicine has developed from the sequencing of the human genome
According to recent research from Brisbane, Australia, “Long QT syndrome (LQTS) is a cardiac disorder associated with ... Presently 12 genes associated with LQTS have been identified with differing signs and symptoms, depending on the ...
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