Nitric Oxide and Cancer Pathogenesis and Therapy

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs.

Nitric Oxide and Cancer  Pathogenesis and Therapy

Advances in Nitric Oxide and Cancer is a volume that serves to give the latest research on nitric oxide (NO) and cancer. More specifically, the volume reviews significant advances in the application of NO-mediated drugs. The volume explores nitric oxide and its relationship to cancer spanning from its roles in the pathogenesis, prognosis, gene and protein modifications, regulation of resistance to cytotoxics, and therapeutic applications. With chapters written by leading experts, the volume addresses the burgeoning interest in a rapidly advancing field and provides a valuable resource to scientists who have initiated research as well as clinical investigations in their laboratories on the various roles of NO and cancer.

Nitric Oxide NO and Cancer

The various chapters in this comprehensive volume (25 contributions), written by noted experts in the field, bring up-to-date our current understanding and prospective future clinical applications of NO.

Nitric Oxide  NO  and Cancer

Nitric Oxide (NO) is a pleitropic, ubiquitous modulator of cellular functions. Aryl nitrite and glyceryl trinitrate, representative intravasadilators, were introduced as therapeutic agents more than a century ago for relief from acute attacks of angina. The vasodilator action is mediated by the release of NO following treatment. NO has important therapeutic applications in several diseases such as inflammatory diseases, erectile dysfunction, inflammation, pain and neural protective activity. However, the role of NO in cancer and its application in therapy has received little attention. This monograph will be the first to focus on studies that investigate the role of NO in tumor cell pathogenesis, growth, angiogenesis, response to cytotoxic therapies and NO translational applications in cancer therapy, alone or in conjunction with other therapies.

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis, ... Is nitric oxide (NO) the last word in radiosensitization? ... Nitric oxide and cancer: pathogenesis and therapy.

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders

Therapeutic Application of Nitric Oxide in Cancer and Inflammatory Disorders presents updated reviews on the chemistry, signaling, pre-clinical and clinical activities on the role of nitric oxide donors/inhibitors used alone and in combination with other therapeutic agents for the treatment of a variety of diseases. This book examines various studies related to the application of novel therapeutic NO (donors/inhibitors) compounds in the treatment of various cancers. These studies have been shown to exert significant therapeutic activities against various cancers and various inflammatory diseases such as rheumatoid arthritis, Crohn’s disease, allergies, and asthma, where no current effective therapies exist. Pathologies based on functional and structural vascular alterations are also taken into consideration. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides readers with a clear overview of the recent findings and references as well as summaries, significant molecular pathways, and conclusions Discusses new ideas proposed and makes suggestions for further investigations that will advance the field Presents introductory and summary information on the contributions of the field, all the findings of the studies discussed, and projects future goals for research

Nitric Oxide Donor Induced in Chemosensitization

[134] BaritakiS, Huerta-Yepez S, Sakai T, Spandidos DA, Bonavida B. Chemotherapeutic drugs sensitize cancer cells to TRAIL-mediated apoptosis: up-regulation of DR5 and inhibition of ... Nitric Oxide and Cancer: Pathogenesis and Therapy.

Nitric Oxide  Donor Induced  in Chemosensitization

Nitric Oxide as a Chemosensitizing Agent, Volume One is the first book to describe several reviews by authoritative scientists and clinicians on novel findings in the reversal of drug resistant cancers by the combination treatment of Nitric Oxide and sub toxic concentrations of chemotherapeutic drugs that have been reported in both in vitro, in vivo and preclinical models. The book describes the various underlying chemical, molecular and genetic mechanisms by which NO and NO reactive species mediate the anti-cancer activity, thus reducing the threshold of drug resistance and enabling chemo therapeutic drugs to induce their cytotoxic activity and reversal of resistance. This book exposes scientists and clinicians to this highly beneficial topic for research investigations and pharmaceutical companies to new avenues for R&D. It is a valuable resource for cancer researchers, oncologists and members of several areas of the biomedical field who are interested in understanding how to use Nitric Oxide as a sensitizing agent for chemotherapy. Brings updated information as reviewed by experts in the field Presents expert analysis and summary of reported and novel findings and potential translational application in cancer patients Describes molecular mechanisms with new and helpful approaches that can be used in reader investigations

Nitric Oxide

Nitric oxide and cancer: pathogenesis and therapy. Switzerland: Springer International Publishing; 2015. p. 1–21. Du Q, Geller DA. Cross-regulation between Wnt and NF-kB signaling pathways. For Immunopathol Dis Therap 2010;1:155–81.

Nitric Oxide

Nitric Oxide: Biology and Pathobiology, Third Edition, provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs. With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid across the fields of biochemistry, chemistry, molecular biology, gene therapy, cell biology, immunology, pharmacology, neuroscience, and physiology. Includes perspectives from Jack Lancaster on the discovery of EDRF and nitric oxide Provides detailed coverage of the new gaseous signaling agents Features expanded coverage on the principles of biology, including nitric oxide synthases, nitrite and nitrate biology and pathobiology, and signaling mechanisms Incorporates expanded pathobiology coverage, including nitric oxide and cardiovascular function, obesity, diabetes, and erectile function/dysfunction

Epidemiology of Brain and Spinal Tumors

Bonavida, B. (2015). Nitric oxide and cancer: Pathogenesis and therapy. Springer. Chang, E. L., Brown, P. D., Lo, S. S., Sahgal, A., & Suh, J. H. (2018). Adult CNS radiation oncology: Principles and practice. Springer.

Epidemiology of Brain and Spinal Tumors

Epidemiology of Brain and Spinal Tumors provides a single volume resource on imaging methods and neuroepidemiology of both brain and spinal tumors. The book covers a variety of imaging techniques, including computed tomography (CT), MRI, positron emission tomography (PET), and other laboratory tests used in diagnosis and treatment. Detailed epidemiology, various imaging methods, and clinical considerations of tumors of the CNS make this an ideal reference for users who will also find diverse information about structures and functions, cytology, epidemiology (including molecular epidemiology), diagnosis and treatment. This book is appropriate for neuroscience researchers, medical professionals and anyone interested in a complete guide to visualizing and understanding CNS tumors. Provides the most up-to-date information surrounding the epidemiology, biology and imaging techniques for brain and spinal tumors, including CT, MRI, PET, and others Includes full color figures, photos, tables, graphs and radioimaging Contains information that will be valuable to anyone interested in the field of neurooncology and the treatment of patients with brain and spinal tumors Serves as a source of background information for basic scientists and pharmaceutical researchers who have an interest in imaging and treatment

Redox and Metabolic Circuits in Cancer

Bettaieb A, Plenchette S, Paul C, Laurens V, Romagny S, Jeannin J. Nitric Oxide and Cancer: Pathogenesis and Therapy. (Springer International Publishing) (2015). 9. Nakamura T, Tu S, Akhtar M, Sunico C, Okamoto SI, Lipton S. Aberrant ...

Redox and Metabolic Circuits in Cancer

Living cells require a constant supply of energy for the orchestration of a variety of biological processes in fluctuating environmental conditions. In heterotrophic organisms, energy mainly derives from the oxidation of carbohydrates and lipids, whose chemical bonds breakdown allows electrons to generate ATP and to provide reducing equivalents needed to restore the antioxidant systems and prevent from damage induced by reactive oxygen and nitric oxide (NO)-derived species (ROS and RNS). Studies of the last two decades have highlighted that cancer cells reprogram the metabolic circuitries in order to sustain their high growth rate, invade other tissues, and escape death. Therefore, this broad metabolic reorganization is mandatory for neoplastic growth, allowing the generation of adequate amounts of ATP and metabolites, as well as the optimization of redox homeostasis in the changeable environmental conditions of the tumor mass. Among these, ROS, as well as NO and RNS, which are produced at high extent in the tumor microenvironment or intracellularly, have been demonstrated acting as positive modulators of cell growth and frequently associated with malignant phenotype. Metabolic changes are also emerging as primary drivers of neoplastic onset and growth, and alterations of mitochondrial metabolism and homeostasis are emerging as pivotal in driving tumorigenesis. Targeting the metabolic rewiring, as well as affecting the balance between production and scavenging of ROS and NO-derived species, which underpin cancer growth, opens the possibility of finding selective and effective anti-neoplastic approaches, and new compounds affecting metabolic and/or redox adaptation of cancer cells are emerging as promising chemotherapeutic tools. In this Research Topic we have elaborated on all these aspects and provided our contribution to this increasingly growing field of research with new results, opinions and general overviews about the extraordinary plasticity of cancer cells to change metabolism and redox homeostasis in order to overcome the adverse conditions and sustain their “individualistic” behavior under a teleonomic viewpoint.

Frontiers in Anti Cancer Drug Discovery

The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery.

Frontiers in Anti Cancer Drug Discovery

Frontiers in Anti-Cancer Drug Discovery is an Ebook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write contributions on all areas of rational drug design and drug discovery, including medicinal chemistry, in-silico drug design, combinatorial chemistry, high-throughput screening, drug targets, recent important patents, and structure-activity relationships. The Ebook series should prove to be of interest to all pharmaceutical scientists involved in research in Anti-Cancer drug design and discovery. Each volume is devoted to the major advances in Anti-Cancer drug design and discovery. The Ebook series is essential reading for all scientists involved in drug design and discovery who wish to keep abreast of rapid and important developments in the field.

Caveolins in Cancer Pathogenesis Prevention and Therapy

Treatment with a specific nitric-oxide synthase inhibitor, L-NAME, restores normal microvascular permeability in Cav-1 null mice. J Biol Chem 277:40091–40098 20. Drab M, Verkade P, Elger M, Kasper M, Lohn M, Lauterbach B, Menne J, ...

Caveolins in Cancer Pathogenesis  Prevention and Therapy

Caveolins are important structural proteins of Caveolae, small invaginations of the membrane. They have been shown to play an important role in the pathogenesis of multiple cancers. In this volume, we will mainly focus on the importance of Caveolin-1 in breast, prostate, lung, skin, colon, pancreatic and brain cancers with also a mention of the novel role of Caveolin-3 in breast cancer.

Inflammation in the Pathogenesis of Chronic Diseases

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors.

Inflammation in the Pathogenesis of Chronic Diseases

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

Molecular Basis of Oxidative Stress

Next, the book: Presents new mechanistic insights into how oxidative damage of biomolecules occurs Examines how these oxidative events effect cellular metabolism Investigates the role of oxidative stress in the pathogenesis of cancer, ...

Molecular Basis of Oxidative Stress

Sets the stage for the development of better diagnostictechniques and therapeutics Featuring contributions from an international team of leadingclinicians and biomedical researchers, Molecular Basis ofOxidative Stress reviews the molecular and chemical bases ofoxidative stress, describing how oxidative stress can lead to thedevelopment of cancer and cardiovascular and neurodegenerativediseases. Moreover, it explains the potential role of free radicalsin both the diagnosis and the development of therapeutics to treatdisease. Molecular Basis of Oxidative Stress is logicallyorganized, beginning with a comprehensive discussion of thefundamental chemistry of reactive species. Next, the book: Presents new mechanistic insights into how oxidative damage ofbiomolecules occurs Examines how these oxidative events effect cellularmetabolism Investigates the role of oxidative stress in the pathogenesisof cancer, neurodegenerative disease, cardiovascular disease, andcystic fibrosis Explores opportunities to improve the diagnosis of disease andthe design of new therapeutic agents Readers will find much novel information, including new radicalchemistries and the latest discoveries of how free radicals reactwith biomolecules. The contributors also present recent findingsthat help us better understand the initiation of oxidative stressand the mechanisms leading to the pathogenesis of variousdiseases. Throughout the book, the use of molecular structures helpsreaders better understand redox chemistry. In addition, plenty ofdetailed figures illustrate the mechanisms of oxidative stress anddisease pathogenesis. Examining everything from the basic chemistry of oxidativestress to the pathogenesis of disease, Molecular Basis ofOxidative Stress will help readers continue to explore thenature of oxidative stress and then use that knowledge to developnew approaches to prevent, detect, and treat a broad range ofdisease conditions.

Medical Genetics of Non Small Cell Lung Cancer

This article collection reviews the medical genetics of non-small cell lung cancer and includes 25 papers by various authors.

Medical Genetics of Non Small Cell Lung Cancer

This article collection reviews the medical genetics of non-small cell lung cancer and includes 25 papers by various authors. Topics include: Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure; Osteopontin genetic variants are associated with overall survival in advanced non-small-cell lung cancer patients and bone metastasis; Emerging roles of Nrf2 signal in non-small cell lung cancer; Osteopontin is a prognostic biomarker in non-small cell lung cancer; PIWIL2 promotes progression of non-small cell lung cancer by inducing CDK2 and Cyclin A expression; Metabolic diversity in human non-small cell lung cancer; Clinical outcomes in ALK-rearranged lung adenocarcinomas according to ALK fusion variants; MiR-133a is downregulated in non-small cell lung cancer: a study of clinical significance; A genetic variant in long non-coding RNA MALAT1 associated with survival outcome among patients with advanced lung adenocarcinoma: a survival cohort analysis; Mutation status concordance between primary lesions and metastatic sites of advanced non-small-cell lung cancer and the impact of mutation testing methodologies: a literature review; Predictive biomarkers in precision medicine and drug development against lung cancer; Characterization of a genetic mouse model of lung cancer: a promise to identify Non-Small Cell Lung Cancer therapeutic targets and biomarkers; Genetic polymorphisms in the endothelial nitric oxide synthase gene correlate with overall survival in advanced non-small-cell lung cancer patients treated with platinum-based doublet chemotherapy; Major milestones in translational oncology; Detection of the transforming AKT1 mutation E17K in non-small cell lung cancer by high resolution melting; SFRP1 is a possible candidate for epigenetic therapy in non-small cell lung cancer; Synthetic lethality in lung cancer and translation to clinical therapies; Targeted therapies for patients with advanced NSCLC harboring wild-type EGFR: what's new and what's enough; Cisplatin sensitivity is enhanced in non-small cell lung cancer cells by regulating epithelial-mesenchymal transition through inhibition of eukaryotic translation initiation factor 5A2; Genetic polymorphisms of glutathione S-transferase M1 and T1, and evaluation of oxidative stress in patients with non-small cell lung cancer; PD-L1 biomarker testing for non-small cell lung cancer: truth or fiction?; CD73/NT5E is a target of miR-30a-5p and plays an important role in the pathogenesis of non-small cell lung cancer; Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer; Clinical outcome and expression of mutant P53, P16, and Smad4 in lung adenocarcinoma: a prospective study; Towards standardization of next-generation sequencing of FFPE samples for clinical oncology: intrinsic obstacles and possible solutions. Proceeds from the sale of this book go to the support of an elderly disabled person.

Gastrointestinal Tissue

Gastrointestinal Tissue: Oxidative Stress and Dietary Antioxidants brings together leading experts from world renowned institutions, combining the basic mechanisms of gastrointestinal diseases with information regarding new and alternative ...

Gastrointestinal Tissue

Gastrointestinal Tissue: Oxidative Stress and Dietary Antioxidants brings together leading experts from world renowned institutions, combining the basic mechanisms of gastrointestinal diseases with information regarding new and alternative treatments. The processes within the science of oxidative stress are described in concert with other processes, including apoptosis, cell signaling and receptor mediated responses, further recognizing that diseases are often multifactorial with oxidative stress as a component. By combining the critical molecular processes underlying free radical mediated pathologies and the role of dietary antioxidant molecules, a connection is made that helps advance therapies and the prevention of gastrointestinal pathological processes. This important reference is well designed with two complementary sections. Section One, Oxidative Stress and Gastroenterology, covers the basic processes of oxidative stress from molecular biology to whole organs, the gastrointestinal anatomy and sources of oxidative stress and free radicals and their products in gastrointestinal diseases. Section Two, Antioxidants and Gastroenterology covers antioxidants in foods, including plants and components. Covers the science of oxidative stress in gastrointestinal tissue and associated conditions and scenarios Provides information on optimal levels for human consumption of antioxidants, suggested requirements per day, recommended dietary allowances and curative/preventive effects of dietary antioxidants Presents an easy to reference guide with two complementary sections that discuss the pathophysiology of gastrointestinal diseases in relation to oxidative stress and antioxidant therapies

Skin Cancer Pathogenesis and Diagnosis

Major mechanism of MDSCs immunosuppressive effect is through production of nitric oxide, anti-infiammatory cytokines, and reactive ... For therapeutic purpose, tumor tissue derived lymphocytes are harvested and expanded in vitro first, ...

Skin Cancer  Pathogenesis and Diagnosis

This book highlights the molecular and cellular mechanisms involved in the initiation and progression of skin cancer. It also explains the role of the environment in skin cancer development and explores the potential of microbiome in the diagnosis, prevention and treatment of skin cancer. The book also presents potential biomarkers for early detection of skin cancer and discusses recent advances in skin cancer prevention and treatment using photodynamic therapy. Lastly, it summarizes the applications of biomedical engineering, non-coding and nanotechnology in the diagnosis and therapeutics in skin cancer. It is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, and dermatologists.

Cumulated Index Medicus

Mülsch A. PQQ , involved with nitric oxide in bone metabolism ? Pathogenesis and treatment of neonatal and postnatal Arzneimittelforschung 1994 Mar ; 44 ( 3A ) : 408–11 ( 32 ref . ) Gallop PM , et al . Connect Tissue Res 1993 ; 29 ( 2 ) ...

Cumulated Index Medicus


Prognostic and Therapeutic Applications of Rkip in Cancer

SEC-induced activation of ANXA7 GTPase suppresses prostate cancer metastasis. ... [99] Bonavida B, Garban H. Nitric oxide-mediated sensitization of resistant tumor cells to apoptosis by chemo-immunotherapeutics.

Prognostic and Therapeutic Applications of Rkip in Cancer

Prognostic and Therapeutic Applications of RKIP in Cancer provides updated reviews on the chemistry, signaling, pre-clinical and clinical activities, and role of RKIP expression levels for diagnostics, prognosis and potential interventions. The development of novel compounds and conjugates that selectively induce RKIP expression in cancer open a novel era of new therapeutics and their potential in the treatment of highly resistant cancers and metastases. Edited and written by internationally renowned experts in the field of novel therapeutics for cancer, this book is a valuable source for cancer researchers, medical scientists, clinicians, clinical pharmacologists, and graduate students. Provides an update from experts in the field on diagnostics, prognostics and therapeutics Brings a clear overview of recent findings and references, as well as summaries, significant molecular pathways, and conclusions in each chapter Provides a general introductory chapter on contributions in the field and a chapter summary, with synthesized findings and a projection of future goals

Liver Pathophysiology

Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies.

Liver Pathophysiology

Liver Pathophysiology: Therapies and Antioxidants is a complete volume on morphology, physiology, biochemistry, molecular biology and treatment of liver diseases. It uses an integral approach towards the role of free radicals in the pathogenesis of hepatic injury, and how their deleterious effects may be abrogated by the use of antioxidants. Written by the most prominent authors in the field, this book will be of use to basic and clinical scientists and clinicians working in the biological sciences, especially those dedicated to the study and treatment of liver pathologies. Presents the most recent advances in hepatology, with a special focus on the role of oxidative stress in liver injury. Provides in vivo and in vitro models to study human liver pathology. Explains the beneficial effects of antioxidants on liver diseases. Contains the most recent and modern treatments of hepatic pathologies, including, but not limited to, stem cells repopulation, gene therapy and liver transplantation.

Cholesterol and Oxysterols as Signal Molecules in Human Pathophysiology and Cancer Implications for New Therapeutic Strategies

Taken together, estrogen and ERs play important roles in lung cancer pathogenesis and treatment. ... and it inhibits both transcriptional and non-transcriptional estrogendependent production of nitric oxide by vascular cells.

Cholesterol and Oxysterols as Signal Molecules in Human Pathophysiology and Cancer  Implications for New Therapeutic Strategies


YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer

Motexafin gadolinium: a novel redox active drug for cancer therapy. Semin Cancer Biol 2006;16:466–76. [13] Vasquez-Vivar J, Martasek P, Hogg N, Masters BS, Pritchard Jr. KA, Kalyanaraman B. Endothelial nitric oxide synthase-dependent ...

YY1 in the Control of the Pathogenesis and Drug Resistance of Cancer

YY1 Is Pivotal in the Control of the Pathogenesis and Drug Resistance of Cancer: A Critical Therapeutic Target describes the current state-of-the-art of the transcription factor YY1 that is overexpressed in the majority of cancers and a central factor that regulates all of the major features and characteristics of human cancers. This book emphasizes the biochemical, molecular and genetic underlying mechanisms by which YY1 regulates its pro-cancerous activities. In addition, it also describes the role of YY1 in the regulation of tumor cell resistance to conventional chemo and immunotherapies and the important role of inhibiting YY1 in cancer. This book is a valuable source for cancer researchers, oncologists and several members of medical and biomedical field who are interested in understanding further the role of YY1 in cancer. Provides a thorough understanding of the underlying mechanisms by which YY1 regulates cancer cell phenotype and unique characteristics Discusses the novel mechanisms of YY1 regulation of tumor cell resistance and means to overcome resistance Encompasses new examples of newly developed non-toxic and selective inhibitors targeting YY1

Free Radicals and Inhalation Pathology

This book summarizes highlights in the field of free radicals in medicine and biology, with a detailed analysis of the extensive recent literature.

Free Radicals and Inhalation Pathology

This book summarizes highlights in the field of free radicals in medicine and biology, with a detailed analysis of the extensive recent literature. It describes results from experimental research work on dust inhalation, hypoxia, and environmental toxicology using morphologic methods such as electron microscopy, interference microscopy and time-lapse techniques in tissue cultures. It also discusses free radical reactions that are probably involved in the pathogenesis of both physical and chemical environmental hazards and provides a list of radical scavengers that are useful prophylatic agents in case of unavoidable exposure. A short history of dust diseases that have challenged mankind since prehistoric times serves as an introduction to this comprehensive treatise. It is hoped that by covering this field in one monograph, adding light will be shed on the important role of both oxygen- and nitrogen-centered radicals in disease pathogenesis, a role that is receiving increasing recognition. The CD-ROM included with this volume lists nearly 25,000 literature citations useful as a reference source for researches, clinicians and students.