Organ Selective Actions of Steroid Hormones

Molecular biology has opened the way for more detailed investigation of the complex set of intracellular interactions contributing to organ-selective actions of steroids and steroid-like compounds such as vitamin D. In this volume leading ...

Organ Selective Actions of Steroid Hormones

Steroids regulate differentiation, growth and functioning of many tissues via a nuclear receptor gene activation mechanism. Molecular biology has opened the way for more detailed investigation of the complex set of intracellular interactions contributing to organ-selective actions of steroids and steroid-like compounds such as vitamin D. In this volume leading experts address basic molecular mechanisms of tissue specificity and related issue, with the goal of attaining a better understanding of the underlying mechanisms of organ selective actions of steroids. Discussed is the extent to which tissue specificity might selectively be modified by chemical modification of the hormones and how this may be applied towards improved therapies by taking advantage of tissue selectivity.

Organ Selective Actions of Steroid Hormones

Molecular biology has opened the way for more detailed investigation of the complex set of intracellular interactions contributing to organ-selective actions of steroids and steroid-like compounds such as vitamin D. In this volume leading ...

Organ Selective Actions of Steroid Hormones

Steroids regulate differentiation, growth and functioning of many tissues via a nuclear receptor gene activation mechanism. Molecular biology has opened the way for more detailed investigation of the complex set of intracellular interactions contributing to organ-selective actions of steroids and steroid-like compounds such as vitamin D. In this volume leading experts address basic molecular mechanisms of tissue specificity and related issue, with the goal of attaining a better understanding of the underlying mechanisms of organ selective actions of steroids. Discussed is the extent to which tissue specificity might selectively be modified by chemical modification of the hormones and how this may be applied towards improved therapies by taking advantage of tissue selectivity.

Von der Wahrnehmung zur Erkenntnis From Perception to Understanding

16 (1995): Organ-Selective Actions of Steroid Hormones Editors: D.T. Baird, G. Schütz, R. Krattenmacher Vol. 17 (1996): Alzheimer's Disease Editors: J.D. Turner, K. Beyreuther, F. Theuring Vol. 18 (1997): The Endometrium as a Target for ...

Von der Wahrnehmung zur Erkenntnis   From Perception to Understanding

Der vorliegende Band ist eine Zusammenfassung der Beiträge, die auf einem Symposium mit dem Titel "Von der Wahrnehmung zur Erkenntnis" am 7. Februar 2004 in Berlin stattfand. Anlass war der sechzigste Geburtstag von Professor Dr. Dr. h.c. Günter Stock, Vorstand der Schering AG im Bereich Forschung und Begründer der Schering Forschungsgesellschaft. In dieser Publikation laden Sie international führende Wissenschaftler zu einer Reise ein, die von der Wahrnehmung zur Erkenntnis von einem evolutionären Rückblick "Woher kommen wir, was macht uns erkenntnisfähig" bis hin zur Philosophie des Erkennens führt. Im Zentrum der Betrachtung steht dabei der Mensch und seine Wahrnehmung.

New Mechanisms for Tissue Selective Estrogen Free Contraception

16 ( 1995 ) : Organ - Selective Actions of Steroid Hormones Editors : D.T. Baird , G. Schütz , R. Krattenmacher Vol . 17 ( 1996 ) : Alzheimer's Disease Editors : J.D. Turner , K. Beyreuther , F. Theuring Vol .

New Mechanisms for Tissue Selective Estrogen Free Contraception

Combined oral contraceptives are the most convenient and accepted method of hormonal contraception. Nevertheless, the medical community and consumers constantly demand innovation, additional benefits during use and lower hormonal load despite the high safety profile of available products. At the Ernst Schering Research Foundation Workshop 52, new perspectives and mechanisms for tissue-selective, estrogen-free contraception were discussed. The aim of the workshop was to bring together experts in the field of molecular and pharmacodynamic action of progestins with clinicians and medical experts to discuss potential medical endpoints, physiological reactions and (bio)marker useful describing the tissue selectivity and the contraceptive action of new progestins in different target organs. A major factor for successful realization of these new concepts is a deeper understanding of local pharmacological responses to progestins in general and to new progestins in particular.

Estrogen and the Vessel Wall

“Estrogen receptor-associated proteins: possible mediators of hormone-induced transcription. ... “Members of the steroid hormone receptor superfamily interact with TFIIB (S300-II). ... Organ-Selective Actions of Steroid Hormones.

Estrogen and the Vessel Wall

Estrogen and the Vessel Wall marks the start of a new era in understanding the cardiovascular actions of estrogen. It examines the hypothesis, derived from a growing body of epidemiological data, that estrogen acts directly upon the vessel wall to produce beneficial effects in the cardiovascular system. Inspired by a satellite symposium of the IX International Vascular Biology Meeting, additional topics have been included, covered by leading experts. All subjects have been brought together here to produce an outstanding and integral publication, a milestone in the field of Vascular Research.

New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

16 (1995): Organ-Selective Actions of Steroid Hormones Editors: D. T. Baird, G. Schütz, R. Krattenmacher Vol. 17 (1996); Alzheimer's Disease Editors: J.D. Turner, K. Beyreuther, F. Theuring Vol. 18 (1997): The Endometrium as a Target ...

New Molecular Mechanisms of Estrogen Action and Their Impact on Future Perspectives in Estrogen Therapy

From our current knowledge, it is obvious that estrogen action in volves more than reproduction and fertility. Rather, estrogens affect and influence a number of other organ systems such as the immune, cardiovascular and central nervous system as well as the gastrointes tinal tract, urinary tract and skeleton. The importance of estrogens and estrogen receptor activity is appreciated from the spectrum of significant physiological dysfunctions that occur when there is a loss The participants of the workshop VI Preface of the hormone or the receptor activity. Loss of estrogen, however (for instance during menopause), occurs with time and results in a variety of clinical conditions. We know that the developmental loss of estrogen, as seen in clinical cases of aromatase gene mutations and experimental models, has dramatic effects in both men and women alike. The evidence that these effects are mediated through the estrogen receptor(s) is based on similar but not always identical phenotypes as observed in experimental animal models of estrogen receptor mutations as well as the single clinical case of an estrogen receptor alpha mutant patient. Developing an understanding of the spectrum of estrogen in a variety of tissues related to the condition of estrogen loss is a major and highly active clinical as well as basic scientific research area. Following the discovery of a second estrogen receptor and possible receptor ligand-independent activity as well as the genomic and non genomic actions of estrogen, it is clear that the mechanisms of the effects of estrogen are multifaceted.

Sex Steroids and Apoptosis In Skeletal Muscle Molecular Mechanisms

An important consideration of this volume is the fact that both estrogen receptors (ERs) and androgen receptors (ARs) are ubiquitously expressed and, as a result, steroid hormones affect growth and different cell functions in several organs ...

Sex Steroids and Apoptosis In Skeletal Muscle  Molecular Mechanisms

This monograph focuses on the actions exerted by sex hormones, 17β-estradiol and testosterone, in skeletal muscle tissue. An important consideration of this volume is the fact that both estrogen receptors (ERs) and androgen receptors (ARs) are ubiquitously expressed and, as a result, steroid hormones affect growth and different cell functions in several organs. Moreover, ERs and ARs may have a non-classical pattern of intracellular localizations, raising complexity to the functional roles of estradiol and testosterone. Readers will find key information about the role of sex hormones in mitochondrial physiology and their relation with ageing, apoptosis, and sarcopenia. Chapters integrate important points with the latest information on the subject, including work of leading researchers studying the cellular and molecular mechanisms underlying the age-linked changes in muscle tissue while highlighting the role of satellite cells. Furthermore, the book presents a chapter about phytoestrogens (compounds which are structurally very similar to estrogen 17β-estradiol) and their selective action on sex steroid receptors (specifically, they have a higher affinity for ERβ receptors than ERα receptors). The book is recommended reading for scientists and clinicians involved in the field of medical and health sciences as well as for scholarly readers (students of biochemistry and medicine) who are interested in the molecular mechanism of cellular apoptosis regulated by steroid hormones.

Biologie und Epidemiologie der Hormonersatztherapie Biology and Epidemiology of Hormone Replacement Therapy

16 (1995): Organ-Selective Actions of Steroid Hormones Editors: D.T. Baird, G. Schütz, R. Krattenmacher Vol. 17(1996): Alzheimer's Disease Editors: J.D. Turner, K. Beyreuther, F. Theuring Vol. 18 (1997): The Endometrium as a Target for ...

Biologie und Epidemiologie der Hormonersatztherapie   Biology and Epidemiology of Hormone Replacement Therapy

This volume contains an advanced level discussion on the appropriateness of hormone replacement therapy (HRT) in modern postmenopausal women on the basis of evidence provided by recent epidemiological studies. It addresses all aspects of benefits and risks associated with HRT. It focuses, however, on cancer risk and on risk of breast cancer in particular. The book advocates further epidemiological studies which incorporate pathobiological assessments.

Leucocyte Trafficking

The Role of Fucosyltransferases and Selectins A. Hamann, Khusru Asadullah, A. Schottelius. Vol . 16 ( 1995 ) : Organ - Selective Actions of Steroid Hormones Editors : D.T. Baird , G. Schütz , R. Krattenmacher Vol .

Leucocyte Trafficking

An essential component of inflammation is the migration of circulating leukocytes from blood into tissues. This process is characterized by a multistep paradigm of sequential cell adhesion and activation events that lead to the extravasation of specific leukocyte subsets to different tissues in health and disease. The first step of leukocyte extravasation, the rolling of leukocytes, is primarily mediated by the interactions of selectins and their ligands. It has recently become evident that fucosyltransferases are crucial for selectin ligand synthesis, inflammation, and skin homing. This book provides an in-depth overview of the mechanisms of leukocyte trafficking and of the molecular mechanisms of selectin/selectin ligand interactions and discusses options for pharmacological intervention to treat inflammatory diseases.

Appropriate Dose Selection How to Optimize Clinical Drug Development

16 (1995): Organ-Selective Actions of Steroid Hormones Editors: D.T. Baird, G. Schütz, R. Krattenmacher Vol. 17(1996): Alzheimer's Disease Editors: J.D. Turner, K. Beyreuther, F. Theuring Vol. 18 (1997): The Endometrium as a Target for ...

Appropriate Dose Selection   How to Optimize Clinical Drug Development

Optimal dose individualization has become more important in improving clinical efficacy and safety. This is due in part to the variability in drug response. Therefore, the role of optimal dose finding in early clinical drug development so as to maximize successful clinical use is emphasized. This book reviews innovative methods, tools and examples of rational drug development strategies, particularly for novel oncological agents.

Systems Biology

16 (1995): Organ-Selective Actions of Steroid Hormones Editors: D.T. Baird, G. Schütz, R. Krattenmacher Vol. 17(1996): Alzheimer's Disease Editors: J.D. Turner, K. Beyreuther, F. Theuring Vol. 18 (1997): The Endometrium as a Target for ...

Systems Biology

This volume features contributions from participants of an ESRF Workshop on "Systems Biology" held in Berkeley, USA, in November 2005. Significant progress has been made in developing technologies that enable systems interrogations at a molecular level. Recent successes and challenges of applying systems level measurements to the different steps of drug discovery and development in the pharmaceutical industry are summarized.

The Role of Natural Products in Drug Discovery

21 (1997): Nitric Oxide, Cytochromes P450, and Sexual Steroid Hormones Editors: J.R. Lancaster, J.F. Parkinson Vol. 22(1997): Impact of Molecular Biology and New Technical ... 16 (1995). Organ-Selective Actions of Steroid Hormones.

The Role of Natural Products in Drug Discovery

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Chemokine Roles in Immunoregulation and Disease

16 ( 1995 ) : Organ - Selective Actions of Steroid Hormones Editors : D.T. Baird , G. Schütz , R. Krattenmacher Vol . 17 ( 1996 ) : Alzheimer's Disease Editors : J.D. Turner , K. Beyreuther , F. Theuring Vol .

Chemokine Roles in Immunoregulation and Disease

The Ernst Schering Workshop on Chemokine Roles in Immunoregulation and Disease, with contributions by leading experts in the field, succinctly summarizes cutting-edge research in immunology, protein chemistry, and disease. This book gives an up-to-date overview of important developments in immunology with a concise, state-of-the-art review of chemokines. It is a time-saving reference for both researchers and students, providing fast and easy access to the latest information in this important area of research.

Gene Therapy

Organ-Selective Actions of Steroid Hormones Editors: D. T. Baird, G. Schütz, R. Krattenmacher Vol. 17 (1996). Alzheimer's Disease Editors: J.D. Turner, K. Beyreuther, F. Theuring Vol. 18 (1997): The Endometrium as a Target for ...

Gene Therapy

This book is a collection of preclinical and clinical reports on the application of gene therapy to human disease. The two methods available for delivering therapeutic genes to diseased cells, viral and non-viral vector systems, are detailed and characterized. Several reports describe both approaches currently used in gene therapy: the introduction of a wild-type gene to restore normal gene function in diseased cells, and the use of antisense molecules to hinder abnormal gene expression. Clinical studies detail several different strategies for the treatment of cancer and cardiovascular diseases, using genetic material as therapeutic agents. The regulatory issues governing the use of gene therapy in Europe and the United States are also presented. This book highlights the range of applications and demonstrates the rapid progress being made in the field of gene therapy.

New Pharmacological Approaches to Reproductive Health and Healthy Ageing

16 ( 1995 ) : Organ - Selective Actions of Steroid Hormones Editors : D. T. Baird , G. Schütz , R. Krattenmacher Vol . 17 ( 1996 ) : Alzheimer's Disease Editors : J.D. Turner , K. Beyreuther , F. Theuring Vol .

New Pharmacological Approaches to Reproductive Health and Healthy Ageing

Professor Egon Diczfalusy, a pioneer in gynaecological endocrinology and in particular female contraception, celebrated his 80th birthday with a scientific symposium. The participants were scientists from all over the world who had been scholars and close collaborators at different points in time. The interdisciplinary meeting consisted of lectures on the epidemiological impacts of ageing, its challenge for the pharmaceutical industry, philosophical aspects of the future of mankind, and the history and future of contraception. Three round table discussions addressed the hormonal control of reproduction and ageing, new approaches and future perspectives of contraception for women and men, and hormone replacement in the elderly.

Small Molecule Protein Interactions

16 ( 1995 ) : Organ - Selective Actions of Steroid Hormones Editors : D. T. Baird , G. Schütz , R. Krattenmacher Vol . 17 ( 1996 ) : Alzheimer's Disease Editors : J.D. Turner , K. Beyreuther , F. Theuring Vol .

Small Molecule     Protein Interactions

Based on the international workshop on 'Small Molecule - Protein Interactions' held in Berlin, April 24-26, 2002, researchers from industry and academic laboratories describe novel and efficient ways selecting promising new drug targets and developing small molecule inhibitors against them. The structure of the book corresponds to the different aspects of the drug discovery process. All chapters are written by leading experts in the field, who present and discuss the most recent state-of-the-art tools and techniques for the development of novel drugs. The value of the book lies in surveying and summarizing the approaches taken by different companies and institutions giving the reader a balanced view on the use of the latest techniques on the one hand and experience-based assistance in selecting appropriate tools for their own work on the other hand.

New Concepts in Pathology and Treatment of Autoimmune Disorders

16 ( 1995 ) : Organ - Selective Actions of Steroid Hormones Editors : D. T. Baird , G. Schütz , R. Krattenmacher Vol . 17 ( 1996 ) : Alzheimer's Disease Editors : J.D. Turner , K. Beyreuther , F. Theuring Vol .

New Concepts in Pathology and Treatment of Autoimmune Disorders

Autoimmunity, characterized by autoreactive lymphocytes and autoantibodies, is the consequence of a failure to discriminate between self and non-self, and autoimmune diseases are an increasing threat to people living in the industrialized countries. Autoimmune disorders are treatable, but not curable, and patients can face disability at later stages of the disease. Thus, there is a medical and economic need for new concepts and treatments in autoimmune disorders. New concepts and treatments can only be achieved by an interdisciplinary approach bringing together expertise, technologies, and clinical experience. The workshop focused on multiple sclerosis, rheumatoid arthritis and type I diabetes, and discussed conventional drug therapies, gene therapy, cell and tissue transplantation therapies, and first treatments using blood stem cells for reprogramming the patients' immune system.

Advances in Eicosanoid Research

16 ( 1995 ) : Organ - Selective Actions of Steroid Hormones Editors : D. T. Baird , G. Schütz , R. Krattenmacher Vol . 17 ( 1996 ) : Alzheimer's Disease Editors : J.D. Turner , K. Beyreuther , F. Theuring Vol .

Advances in Eicosanoid Research

Over the last few years, we have witnessed tremendous progress in the field of eicosanoids and their therapeutic applications. Receptor an tagonists for leukotrienes have been tested as anti-inflammatories and are on the market as a treatment for asthma. Receptor agonists for pro stacyclin are being tested for the treatment of peripheral vascular dis ease, and selective inhibitors of cyclooxygenase type II were just ap proved for the treatment of rheumatoid arthritis. All these developments are the culmination of many years and man-hours of careful research. The field has now entered an upswing that will result in novel thera peutic applications within the next 10 years. New molecules and me diators have been identified, new enzymes and pathways elucidated and new therapeutic approaches have emerged. The concept of ei cosanoids as "pro-inflammatory" molecules is being challenged, and their role as regulators is increasingly recognized. In fact, some of these molecules may be important endogenous anti-inflammatory agents.

Chemical Genomics

16 (1995): Organ-Selective Actions of Steroid Hormones Editors: D.T. Baird, G. Schütz, R. Krattenmacher Vol. 17 (1996): Alzheimer's Disease Editors: J.D. Turner, K. Beyreuther, F. Theuring Vol. 18 (1997): The Endometrium as a Target for ...

Chemical Genomics

Chemical genomics is a highly interdisciplinary and very exciting field of research both in academics and in the life sciences industry. The Ernst Schering Research Foundation Workshop 58 was organized to bring together scientific leaders in the field to discuss the implications of chemical genomics for drug discovery. Various aspects of the interface between chemistry and biology are covered in this volume, such as chemogenomics efforts in the pharmaceutical industry, diversity-oriented synthesis, chemogenomic approaches to the study of cell function, screening technologies, and natural products as tools in chemical biology.