Recent Advances in Pluripotent Stem Cell-Based Regenerative Medicine Craig
Atwood ... Takahashi K, Prinz M, Stagi M, Chechneva O, Neumann H. TREM2-
transduced myeloid precursors mediate nervous tissue debris clearance and ...
Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. ... Hofer E, Fontana A. T cell suppressor factor from human
glioblastoma cells is a 12.5-kd protein closely related to transforming growth
Author: Craig Atwood
Publisher: BoD – Books on Demand
Pluripotent stem cells have the potential to revolutionise medicine, providing treatment options for a wide range of diseases and conditions that currently lack therapies or cures. This book describes recent advances in the generation of tissue specific cell types for regenerative applications, as well as the obstacles that need to be overcome in order to recognize the potential of these cells.
To achieve this transforming growth factor - B ( TGF - B ) , possibly in concert they
produce : ( a ) haploid gametes with ... and ( b ) sex hormones that regulate
reproducunique glucoconjugate at the surface of the plasma memtive function
and ... 5 - week - old human embryo , the number of migrating ual development of
the entire body – brain , bones and germ cells ... for a pleiotropic growth factor ,
and sexual differentiation , building on earlier knowledge termed stem cell factor (
SCF ) ...
Author: Stephen G. Hillier
Addressing the scientific basis of obstetrics and gynaecology in the 1990s, this textbook focuses on the fundamentals of reproductive medicine from the perspective of molecular and cellular biology. It is aimed primarily at trainees, in particular MROG Part 1 candidates.
Cells Tissues Organs 196:325–338 Moore YR, Dickinson DP, Wikesjö UME (
2010) Growth/differentiation factor-5: a ... Gorni C, Mariani P (2009) Horse bone
marrow mesenchymal stem cells express embryo stem cell markers and show
the ability for ... Recombinant human bone morphogenetic protein-2 use in the off
-label treatment of nonunions and acute fractures: a ... Sakamoto H, Terada M,
Ochiya T (2009) Pleiotropic function of FGF-4: its role in development and stem cells.
Author: Jaroslava Halper
Publisher: Springer Science & Business Media
This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.
1504-1506 The murine and human clones predict a sequence of 179 amino acid
residues for the mature protein . ... human chromosome at region 22q12.q12.2 ,
in close proximity to the gene of oncostatin M. 1507,1508 B. CELLULAR ... LIF
plays an important role , along with IL - 6 and CSF - 3 , in the regulation of
hematopoietic stem cell growth and differentiation . ... in the development of
peripheral neurons from their precursors in the embryonic neural crest as well as
in a diversity of ...
Author: Enrique Pimentel
Publisher: CRC Press
Handbook of Growth Factors, Volume III is devoted to hematopoiesis and its regulation by endogenous factors with growth stimulatory and growth inhibitory properties. The book provides detailed discussions on signaling agents related to the regulation of hematopoiesis, including the interleukins, the colony-stimulating factors, the interferons, the tumor necrosis factors, the erythropoietic growth factors, the platelet-derived growth factor, the leukemia inhibitory factor, and the transferrins. The structure and function of each factor is covered in detail, as well as its receptor and postreceptor mechanism of action and its possible role in neoplastic processes. The book also explores the present state of the knowledge about megakaryocyte growth factors and macrophage-derived growth factors.
J Cell Sci . 2003 Sep 15 ; 116 ( Pt Jan ; 61 ( 1 ) : 147-9 . tiated embryonic stem cells . Du KL , et al . J Biol Chem . ... Hansen B. Med Law . ... Nonaka M , et during
mouse and human development supports the various Baqain ZH , et al . ... sexual function after bilateral internal iliac artery embolization Engineered zinc finger proteins for controlling stem cell fate . ... teratogenicity using Vascular endothelial growth factor and angiogenin levels during EMBRYO RESEARCH FETUS a
Beginning in early embryonic development, multiple growth factor pathways are
essential for viability. ... growth factor beta (TGFβ) family signaling pathways are
important in growth and differentiation, as well as for regulation of embryonic stem cells (ESCs). For example, activins maintain human ESCs in their totipotent
state, whereas bone morphogenetic proteins (BMPs) ... Throughout reproduction,
TGFβ family members function along with other growth factor signaling cascades
Author: Jerome F. Strauss
Publisher: Elsevier Health Sciences
Yen & Jaffe’s Reproductive Endocrinology helps you successfully diagnose and manage the spectrum of female and male reproductive system diseases, from impaired fertility, infertility, and recurrent pregnancy loss through problems of sexual development, puberty, menstrual disturbances, fibroids, endometriosis, and reproductive aging. This trusted endocrinology reference book is ideal for studying or as a quick reference when making daily diagnostic and therapeutic decisions, ensuring it's just the resource you need to offer your patients the best possible care. Apply the latest reproductive endocrinology advances in basic and clinical science, including molecular, cellular, and genetic concepts, and grasp their relevance to pathophysiology, diagnosis, and therapy. Maximize fertility in women and men undergoing chemotherapy and other cancer treatments, and counsel patients on environmental factors affecting reproduction. Stay on top of recent developments including the impact of obesity on fertility; ovarian tissue banking; cryopreservation; pre-implantation genetic diagnosis; ovulation induction; and risks and treatments for steroid hormone-responsive cancers. View basic anatomic structures, endocrine processes, and cell function and dysfunction with absolute clarity through full-color illustrations and new images throughout. Confidently perform procedures through expanded coverage of reproductive and infertility surgery. Apply the latest reproductive endocrinology advances in basic and clinical science, including molecular, cellular, and genetic concepts, and grasp their relevance to pathophysiology, diagnosis, and therapy. Maximize fertility in women and men undergoing chemotherapy and other cancer treatments, and counsel patients on environmental factors affecting reproduction. Stay on top of recent developments including the impact of obesity on fertility; ovarian tissue banking; cryopreservation; pre-implantation genetic diagnosis; ovulation induction; and risks and treatments for steroid hormone-responsive cancers. View basic anatomic structures, endocrine processes, and cell function and dysfunction with absolute clarity through full-color illustrations and new images throughout.
Endoglin is differentially expressed on hematopoietic cells and was recently
recognized as a marker identifying ... can be insinuated from its expression on
various human hematopoietic populations, including early B- cell progenitors and
... are pleiotropic dimeric proteins that signal through different combinations of the
receptors ActRIIA, ActRIIB, ActRIA/ALK2, and ... be important for the differentiation
of mesodermal precursors to hemangioblast fate during embryonic development
Author: Lothar Kanz
A fundamental property of hematopoetic stem cells is their capacity to self-renew, thus providing, in principle, a limitless source of daughter cells and with the same functional properties. This volume presents the most recent developments, and their clinical implications, in hematopoietic stem cell research. The field of hematopoietic stem cell biology is rapidly advancing and new ideas and concepts supported by new technologies provide new discoveries. Topics covered are genetic and epigenetic regulation of stem cells, stem cell plasticity, stem cell regulation and self-renewal, and embryonic stem cells as well as malignant stem cell biology. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.
The sciences and engineering. B. integrity of the RNAs ( mRNAs , rRNAs and
tRNAs ) in translational com plexes . ... However , prior to the work presented
here it was unknown whether cells exert quality control over their mature rRNAs
... To overcome this , a method utilizing existing plasmid rDNA reporters was developed to express and specifically detect mutant rRNAs in yeast . ... The role
of the HUIV26 cryptic collagen epitope on melanoma tumor growth and IGFBP - 4
A number of these changes are responsible for neuronal death of CA3 and hilar cells , which involves necrotic and apoptotic mechanisms ... Navigation of mossy
fiber's growth cones may be facilitated by astrocytes , which would exert ... To
identify proteins involved in the early development of the mammalian cerebral
cortex , we previously used two ... During this period , the cortex develops from a
morphologically homogeneous population of proliferative precursor cells into a
The receptor for HGF is the product of the proto - oncogene cMET , which is
frequently overexpressed in human tumors . HGF signaling is required for
survival during embryonic development , as demonstrated by the lethality of
knockout mice ... that includes VEGF - A ( referred throughout as VEGF ) , VEGF - B , VEGF - C , VEGF - D , and placental growth factor . ... The role of VEGFR - 1 is
less well understood , but it may facilitate the mobilization of endothelial stem cells and has a role ...
Author: Vinay Kumar
Accompanying CD-ROM contains ... "over 100 clinical case studies and approximately 1,500 images ..."--Page 4 of cover.
Developmental Biology 261 ( 2003 ) 165 - 182 S . L . Karsten el al . / Developmental. Ivanova , N . B . , Dimos , J . T . , Schaniel , C . , Hackney , J . A . ,
Moore , K . A . , Lemischka , I . R . , 2002 . A stem cell molecular signature .
Science 298 ...
N . O . F . was a recipient of a fellowship from CNRS - L ' Oréal . prevents clonal evolution and leads to immortalization of primary ... Transforming growth factor - B : pleiotropic role in the regulation of hematopoiesis . ... Separation of human
epidermal stem cells from transit amplifying cells on the basis of differences in
integrin function and ... Expression of TGF - B related Smad proteins in human
epithelial skin tumors . ... on in vitro TGF - B1 promotes epidermal precursor
Therapy - induced acute recruitment of circulating endothelial progenitor cells to
tumors . Science ... Bone marrow - derived circulating endothelial precursors do
not contribute to vascular endothelium and are not needed for tumor growth .
Cell 86 : 589 . 11. Smith , W. C. 1999. TGF B inhibitors : new and unexpected
requirements in vertebrate development . Trends ... Expression cloning of noggin
, a new dorsalizing factor localized to the Spemann organizer in Xenopus
embryos . Cell 70 ... Noggin - mediated antagonism of BMP signaling is required
for growth and patterning of the neural tube and somite . Genes ... Bone
morphogenetic proteins regulate the developmental program of human
hematopoietic stem cells .