Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications o
Author: Renata Pasqualini
Publisher: CRC Press
A True Insider's Guide to the Field - Then and Now Until now, there has not been a book that effectively addresses the historical basis of protein discovery. Featuring contributions from a distinguished international panel of experts, Protein Discovery Technologies elucidates the principles, techniques, strategies, and broad range of applications o
predict protein interactions, rather than to use the whole protein sequences (
Deng, Mehta, Sun, & Chen, 2002; Wojcik & Schachter, 2001). The second group
consists of methods that exploit information on protein structures (Bock et al.,
Author: Taniar, David
Publisher: IGI Global
As information technology continues to advance in massive increments, the bank of information available from personal, financial, and business electronic transactions and all other electronic documentation and data storage is growing at an exponential rate. With this wealth of information comes the opportunity and necessity to utilize this information to maintain competitive advantage and process information effectively in real-world situations. Data Mining and Knowledge Discovery Technologies presents researchers and practitioners in fields such as knowledge management, information science, Web engineering, and medical informatics, with comprehensive, innovative research on data mining methods, structures, tools, and methods, the knowledge discovery process, and data marts, among many other cutting-edge topics.
15 14 protein structures , protein targets are generally selected for their expected
structural distinction from existing protein structures based on ... centers in PSI - 1
choose proteins of biomedical interest , thus having a direct impact on drug discovery . ... The large - scale structural genomics centers utilize robotic
expression platforms as part of their high - throughput technology , making it
possible to test ...
This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and ...
Author: Daniel Chasman
Publisher: CRC Press
This text offers in-depth perspectives on every aspect of protein structure identification, assessment, characterization, and utilization, for a clear understanding of the diversity of protein shapes, variations in protein function, and structure-based drug design. The authors cover numerous high-throughput technologies as well as computational methods to study protein structures and residues. A valuable reference, this book reflects current trends in the effort to solve new structures arising from genome initiatives, details methods to detect and identify errors in the prediction of protein structural models, and outlines challenges in the conversion of routine processes into high-throughput platforms.
proteins for the 20 common amino acids ( 54 ) . These values were derived from
the Xray crystallographic structures of 19 proteins determined at a resolution of at
least 2 Å . Analysis of this data that carbon - alpha and carbon - beta - protons ...
... drug Molecular Diagnostic Diagnostic n the field of cancer diagnostics , early discovery technologies and clinical Tests ... LabVantage ( www.labvantage.com )
have metric proteomic analyses , and protein chips Genomics Research Institute
View the keynote presentations and featured presentations from the 2005 Drug Discovery Technology Development ... PepChip® Peptide Microarrays med
PepChip kinase Custom Peptide Synthesis 1,152 protein kinase substrates on a
Release on 2000 | by Society of Photo-optical Instrumentation Engineers
SurroMed was founded to develop discovery technologies for new biological
markers that will answer these questions . Biological markers will be derived from
the results of many different assays ; cell surface , serum factors and others ,
Author: Society of Photo-optical Instrumentation Engineers
... Chemokines , and Growth Factors o Dendritic Cells 0 Drug Targets from
Genomics : Evolving Tools for Discovery O G - Protein Coupled Receptors (
GPCRs ) , 2nd Edition o hERG : Technology and Market Analysis o High - Growth
Aurora also applies its arsenal of proprietary , therapeutically focused discovery technologies , such as those for orphan G protein - coupled receptors ( GPCRs ) ,
ion channels and enzymes , to develop a deeper understanding of the disease ...
The book brings together the most current advances in mass spectrometry technologies and related methods in order to accomplish this.
Author: Mike S. Lee
Publisher: John Wiley & Sons
Presents Practical Applications of Mass Spectrometry for Protein Analysis and Covers Their Impact on Accelerating Drug Discovery and Development Covers both qualitative and quantitative aspects of Mass Spectrometry protein analysis in drug discovery Principles, Instrumentation, Technologies topics include MS of peptides, proteins, and ADCs , instrumentation in protein analysis, nanospray technology in MS protein analysis, and automation in MS protein analysis Details emerging areas from drug monitoring to patient care such as Identification and validation of biomarkers for cancer, targeted MS approaches for biomarker validation, biomarker discovery, and regulatory perspectives Brings together the most current advances in the mass spectrometry technology and related method in protein analysis
An update to the popular guide to proteomics technology applications in biomedical research Building on the strength of the original edition, this book presents the state of the art in the field of proteomics and offers students and ...
Author: Timothy D. Veenstra
An update to the popular guide to proteomics technology applications in biomedical research Building on the strength of the original edition, this book presents the state of the art in the field of proteomics and offers students and scientists new tools and techniques to advance their own research. Written by leading experts in the field, it provides readers with an understanding of new and emerging directions for proteomics research and applications. Proteomics for Biological Discovery begins by discussing the emergence of proteomics technologies and summarizing the potential insights to be gained from proteome-level research. The tools of proteomics, from conventional to novel techniques, are thoroughly covered, from underlying concepts to limitations and future directions. Later chapters provide an overview of the current developments in post-translational modification studies, structural proteomics, biochemical proteomics, applied proteomics, and bioinformatics relevant to proteomics. Chapters cover: Quantitative Proteomics for Differential Protein Expression Profiling; Protein Microarrays; Protein Biomarker Discovery; Biomarker Discovery using Mass Spectrometry Imaging; Protein-Protein Interactions; Mass Spectrometry Of Intact Protein Complexes; Crosslinking Applications in Structural Proteomics; Functional Proteomics; High Resolution Interrogation of Biological Systems via Mass Cytometry; Characterization of Drug-Protein Interactions by Chemoproteomics; Phosphorylation; Large-Scale Phosphoproteomics; and Probing Glycoforms of Individual Proteins Using Antibody-Lectin Sandwich Arrays. Presents a comprehensive and coherent review of the major issues in proteomic technology development, bioinformatics, strategic approaches, and applications Chapters offer a rigorous overview with summary of limitations, emerging approaches, questions, and realistic future industry and basic science applications Features new coverage of mass spectrometry for high throughput proteomic measurements, and novel quantitation strategies such as spectral counting and stable isotope labeling Discusses higher level integrative aspects, including technical challenges and applications for drug discovery Offers new chapters on biomarker discovery, global phosphorylation analysis, proteomic profiling using antibodies, and single cell mass spectrometry Proteomics for Biological Discovery is an excellent advanced resource for graduate students, postdoctoral fellows, and scientists across all the major fields of biomedical science.
Pharma is running out of "druggable" targets that have not already been addressed by marketed drugs. Therefore, efforts to tackle protein-protein interactions - previously considered "undruggable"--Are becoming increasingly important.
Author: Allan B. Haberman
Pharma is running out of "druggable" targets that have not already been addressed by marketed drugs. Therefore, efforts to tackle protein-protein interactions - previously considered "undruggable" - are becoming increasingly important.
This structural analysis of target proteins . joint research project is significant
because it enables research scientists from 3 ... area targetnew antibiotic drugs
and research and de ing drug discovery , and the development velopment into protein ...
The yeast two - hybrid tech- pensable tool in drug discovery , protein arrays are
just nique can also be used , as it determines if two proteins bind finding their
ground . Protein microarrays will become to each other . important tools in target
Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.
Author: Manikanta Murahari
Publisher: Royal Society of Chemistry
This publication is based on peer-reviewed manuscripts from the 2019 Conference on Drug Design & Discovery Technologies (CDDT) held at Ramaiah University of Applied Sciences, India. Providing a wide range of up to date topics on the latest advancements in drug design and discovery technologies, this book ensures the reader receives a good understanding of the scope of the field. Aimed at scientists, students, regulators, academics and consultants throughout the world, this book is an ideal resource for anyone interested in the state of the art in drug design and discovery.
... C . Microstructure and Function of Cells Clark , C . R . & Moos , W . H . Drug Discovery Technologies Cook , N . Potassium Channels Corkill , J . A . Clinical
Biochemistry : The Analysis of Biologically Important Compounds and Drugs *
Author: Alan Wiseman
Publisher: Ellis Horwood Limited
Category: Technology & Engineering
Presents the important concepts and advances on how to successfully use genetic engineering techniques to obtain human proteins and enzymes - an area of vital importance for the production of human proteins for medical purposes.