Split and Splitless Injection for Quantitative Gas Chromatography

" The Analyst "This is a detailed reference volume filled with practical suggestions and techniques for managing split and splitless injection in the day-to-day world of the working gas chromatographer.

Split and Splitless Injection for Quantitative Gas Chromatography

This comprehensive and unique handbook of split and splitless injection techniques has been completely revised and updated. This new edition offers: - New insights concerning sample evaporation in the injector - Information about matrix effects - A new chapter on injector design The real processes within the injector are for the first time visualized and explained by the CD-ROM included in the book. Furthermore the reader will understand the concepts of injection techniques and get a knowledge of the sources of error. The handbook also includes many practical guidelines. From reviews of former editions: "This substantial book is on injection techniques alone, which ... demonstrates this can have many pitfalls ... no one should be allowed to direct a laboratory doing quantitative analysis by GC without first being thoroughly familar with this book ..." The Analyst "This is a detailed reference volume filled with practical suggestions and techniques for managing split and splitless injection in the day-to-day world of the working gas chromatographer. It will be useful ... for anyone who must work hands-on with GC." Journal of High Resolution Chromatography

Handbook of GC MS

Comprehensive Two-Dimensional Gas Chromatography, LCGC Europe 12 (2003) 2–10. McNamara, K., Leardib, R., Hoffmann, A., ... Grob, K., Split and Splitless Injection for Quantitative Gas Chromatography. Concepts, Processes, Practical ...

Handbook of GC MS

The most important advantage [of this text] is that it has not only been written for the practitioner, but also the analyst who wishes to familiarize himself with any or all the aspects of GC/MS' - AFS - Advances In Food Sciences. This is an updated edition of its bestselling predecessor, Handbook of GC/MS: Fundamentals and Applications that offers broad coverage of the subject, from sample preparation to the evaluation of MS-Data. This edition boasts several new chapters, including Automated Solvent Extraction (ASE), Hyphenation with Isotope Ratio MS, and the TOF-technique

Practical Gas Chromatography

5.5.3.2 Working Rules for LV PTV Injection with Solvent Splitting • 5cmÂ2 mm packing: rapid injection of samples up to 80 μl; larger volumes either by repetitive or by ... Grob K (2001) Split and splitless injection for quantitative GC.

Practical Gas Chromatography

Gas chromatography continues to be one of the most widely used analytical techniques, since its applications today expand into fields such as biomarker research or metabolomics. This new practical textbook enables the reader to make full use of gas chromatography. Essential fundamentals and their implications for the practical work at the instrument are provided, as well as details on the instrumentation such as inlet systems, columns and detectors. Specialized techniques from all aspects of GC are introduced ranging from sample preparation, solvent-free injection techniques, and pyrolysis GC, to separation including fast GC and comprehensive GCxGC and finally detection, such as GC-MS and element-specific detection. Various fields of application such as enantiomer, food, flavor and fragrance analysis, physicochemical measurements, forensic toxicology, and clinical analysis are discussed as well as cutting-edge application in metabolomics is covered.

Gas Chromatography

[14] K. Grob, Split and Splitless Injection for Quantitative Gas Chromatography: Concepts, Processes, Practical Guidelines and Sources of Error, Wiley-VCH, Weinheim, 2007. [15] S. Bieri, P. Christen, M. Biedermann, K. Grob, Inability of ...

Gas Chromatography

Gas Chromatography, Second Edition, offers a single source of authoritative information on all aspects relating to the practice of gas chromatography. A focus on short, topic-focused chapters facilitates the identification of information that will be of immediate interest for familiar or emerging uses of gas chromatography. The book gives those working in both academia and industry the opportunity to learn, refresh and deepen their understanding of fundamental and instrumental aspects of gas chromatography and tools for the interpretation and management of chromatographic data. Users will find a consolidated guide to the selection of separation conditions and the use of auxiliary techniques. This new edition restores the contemporary character of the book with respect to those involved in advancing the technology, analyzing the data produced, or applying the technique to new application areas. New topics covered include hyphenated spectroscopic detectors, micromachined instrument platforms, derivatization and related microchemical techniques, petrochemical applications, volatile compounds in the atmosphere, and more. Includes chapters written by recognized authoritative and visionary experts in the field, thus providing an overview and focused treatments on a single topic Provides comprehensive coverage of modern gas chromatography, from theory, to methods and selected applications Places modern developments in research literature into a general context not always apparent to inexperienced users of the techniques

Principles and Practice of Modern Chromatographic Methods

[36] Crawford Scientific Blog, Gas chromatography hydrogen carrier gas, 4 July 2019, Available from: ... [61] K. Grob, Split and Splitless Injection for Quantitative Gas Chromatography: Concepts, Processes, Practical Guidelines, ...

Principles and Practice of Modern Chromatographic Methods

Principles and Practice of Modern Chromatographic Methods, Second Edition takes a comprehensive, unified approach in its presentation of chromatographic techniques. Like the first edition, the book provides a scientifically rigid, but easy-to-follow presentation of chromatography concepts that begins with the purpose and intent of chromatographic theory - the “what and why that are left out of other books attempting to cover these principles. This fully revised second edition brings the content up-to-date, covering recent developments in several new sections and an additional chapter on composite methods. New topics include sample profiling, sample preparation, sustainable green chemistry, 2D chromatography, miniaturization/nano-LC, HILIC, and more. Contains thorough chapters that begin with an updated schematic overview and a visual representation of the content Avoids the obfuscation of different terminologies and classification systems that are prevalent in the area, such as the relationship between liquid chromatography and column chromatography Provides integrated and comprehensive topic coverage based on chromatographic bibliometrics and survey reports on the relative usage of chromatographic techniques

Analysis of Pesticides in Food and Environmental Samples

Grob, K., Split and Splitless Injection in Capillary GC, Wiley-VCH, New York, 2001. Grob, K., Split and Splitless Injection for Quantitative Gas Chromatography: Concepts, Processes, Practical Guidelines, Sources of Error, 4th edn, ...

Analysis of Pesticides in Food and Environmental Samples

Developing safety regulations for pesticides used around the world—in excess of 2.5 million tons annually—requires reliable analytical methods for assessing their impact in food and in the environment. Analysis of Pesticides in Food and Environmental Samples presents the most effective techniques for analyzing pesticide residues and other chemical contaminants in foods as well as in soil, water, and air. Renowned Scientists Report New Data and Advances in the Field The book introduces sample preparation, extraction, and analytical methods specific to each sample type, including foods from vegetal and animal origin. Other chapters discuss important aspects of quality assurance and the applicability of hyphenated analytical techniques. In addition to a practical chapter on the use of biosensors and immunoassays for monitoring and gathering exposure data, the book addresses regulatory aspects and presents current data on the levels of pesticides found in food and environmental matrices. Latest Methods Help Scientists Develop Safer, More Effective Pesticides Analysis of Pesticides in Food and Environmental Samples enables scientists to measure and predict the behavior and toxicity of pesticides with a higher degree of accuracy. The methodologies and insight in this timely work will contribute to the development of more effective, less toxic pesticides as well as better safety regulations.

Ewing s Analytical Instrumentation Handbook Fourth Edition

Chem., 370: 194–199. dimensional gas chromatography with mass spectrometric detection (GC×GC/MS) applied to the analysis of petroleum.” J. High Resol. ... Split and Splitless Injection for Quantitative Gas Chromatography.

Ewing s Analytical Instrumentation Handbook  Fourth Edition

This handbook is a guide for workers in analytical chemistry who need a starting place for information about a specific instrumental technique. It gives a basic introduction to the techniques and provides leading references on the theory and methodology for an instrumental technique. This edition thoroughly expands and updates the chapters to include concepts, applications, and key references from recent literature. It also contains a new chapter on process analytical technology.

Modern Practice of Gas Chromatography

9.6.3 Advantages and Disadvantages Because it is a cold injection technique that also employs a glass sleeve, PTV injection offers ... K. Grob, Split and Splitless Injectionfor Quantitative Gas Chromatography Concepts, Processes, ...

Modern Practice of Gas Chromatography

The bible of gas chromatography-offering everything the professional and the novice need to know about running, maintaining, and interpreting the results from GC Analytical chemists, technicians, and scientists in allied disciplines have come to regard Modern Practice of Gas Chomatography as the standard reference in gas chromatography. In addition to serving as an invaluable reference for the experienced practitioner, this bestselling work provides the beginner with a solid understanding of gas chromatographic theory and basic techniques. This new Fourth Edition incorporates the most recent developments in the field, including entirely new chapters on gas chromatography/mass spectrometry (GC/MS); optimization of separations and computer assistance; high speed or fast gas chromatography; mobile phase requirements: gas system requirements and sample preparation techniques; qualitative and quantitative analysis by GC; updated information on detectors; validation and QA/QC of chromatographic methods; and useful hints for good gas chromatography. As in previous editions, contributing authors have been chosen for their expertise and active participation in their respective areas. Modern Practice of Gas Chromatography, Fourth Edition presents a well-rounded and comprehensive overview of the current state of this important technology, providing a practical reference that will greatly appeal to both experienced chomatographers and novices.

Advances in Chromatography

Grob, K., Split and Splitless Injection in for Quantitative Gas Chromatography, Wiley-VCH, Weinheim, 2001, p. 257. Grob, K., On-Column Injection in Capillary Gas Chromatography: Basic Technique, Retention Gaps, Solvent Effects, 2nd ed., ...

Advances in Chromatography

For more than four decades, scientists and researchers have relied on the Advances in Chromatography series for the most up-to-date information on a wide range of developments in chromatographic methods and applications. Volume 45 of this authoritative series once again compiles the work of expert contributors in order to present timely and cutting-edge reviews on a variety of related topics. This volume focuses on applying various chromatographic techniques to combinatorial methods and high-throughput analyses. The authors address various limitations to traditional techniques and present developments that enable scientists to analyze a higher volume of smaller molecules under high-throughput conditions more efficiently. Other practical topics include discussions of selection criteria for using alternative solvents and reagents, minimum requirements for utilizing readily available instrumentation and methods for new applications, the use of high-throughput purification for obtaining higher quality leads, and new chromatographic data on organic endocrine disrupters. Advances in Chromatography: Volume 45 provides a good starting point to gain quick and up-to-date knowledge of the field and its most recent developments. Each author's clear presentation of topics and vivid illustrations make the material accessible and engaging to a variety of chemists with different levels of technical skill.

Temperature Programmed Gas Chromatography

8 Jennings, W., Mittlefehldt, E., and Stremple, P. (1997) Analytical Gas Chromatography, 2nd edn, Academic Press, San Diego. 9 Grob, K. (2001) Split and Splitless Injection for Quantitative Gas Chromatography – Concepts, Processes, ...

Temperature Programmed Gas Chromatography

This book provides a comprehensive up-to-date overview of temperature-programmed gas chromatography (GC). The first part of the book introduces the reader to the basics concepts of GC, as well as the key properties of GC columns. The second part describes the mathematical and physical background of GC. In the third part, different aspects in the formation of a chromatogram are discussed, including retention times, peak spacing and peak widths. An invaluable reference for any chromatographer and analytical chemist, it provides all the answers to questions like: * At what temperature does a solute elute in a temperature-programmed analysis? * What is the value of the retention factor of eluting solute? * How wide are the peaks? * How large is the time distance between two peaks? * How do all these parameters depend on the heating rate?

Basic Gas Chromatography

Grob, K. (2007). Split and Splitless Injection for Quantitative Gas Chromatography: Concepts, Processes, Practical Guidelines, Sources of Error. New York: John Wiley and Sons. 2. Snow, N.H. (2018). LC‐GC North America 36 (7): 448–454.

Basic Gas Chromatography

Basic Gas Chromatography, Third Edition provides a brief introduction to GC following the objectives for titles in this series. It should appeal to readers with varying levels of education and emphasizes a practical, applied approach to the subject. : This book provides a quick need-to-know introduction to gas chromatography; still the most widely used instrumental analysis technique, and is intended to assist new users in gaining understanding quickly and as a quick reference for experienced users. The new edition provides updated chapters that reflect changes in technology and methodology, especially sample preparation, detectors and multidimensional chromatography. The book also covers new detectors recently introduced and sample preparation methods that have become much more easily accessible since the previous edition.

Automated Sample Preparation

Injection techniques in capillary GC. Analytical Chemistry 66 (20): 1009A–1019A. 93 Grob, K. (2001). Split and Splitless Injection for Quantitative Gas Chromatography. Concepts, Processes, Practical Guidelines, Sources of Error, ...

Automated Sample Preparation

An essential guide to the proven automated sample preparation process While the measurement step in sample preparation is automated, the sample handling step is manual and all too often open to risk and errors. The manual process is of concern for accessing data quality as well as producing limited reproducibility and comparability. Handbook of Automated Sample Preparation for CG-MS and LC-MS explores the advantages of implementing automated sample preparation during the handling phase for CG-MS and LC-MS. The author, a noted expert on the topic, includes information on the proven workflows that can be put in place for many routine and regulated analytical methods. This book offers a guide to automated workflows for both on-line and off-line sample preparation. This process has proven to deliver consistent and comparable data quality, increased sample amounts, and improved cost efficiency. In addition, the process follows Standard Operation Procedures that are essential for audited laboratories. This important book: Provides the information and tools needed for the implementation of instrumental sample preparation workflows Offers proven and detailed examples that can be adapted in analytical laboratories Shows how automated sample preparation can reduce cost per sample, increase sample amounts, and produce faster results Includes illustrative examples from various fields such as chemistry to food safety and pharmaceuticals Written for personnel in analytical industry, pharmaceutical, and medical laboratories, Handbook of Automated Sample Preparation for CG-MS and LC-MS offers the much-needed tools for implementing the automated sample preparation for analytical laboratories.

Forensic Applications of Gas Chromatography

Split and splitless injection for quantitative gas chromatography, 4th, completely rev. ed. Chichester, UK: John Wiley & Sons. Grob, R. L., and E. F. Barry. 2004. Modern practice of gas chromatography, 4th ed.

Forensic Applications of Gas Chromatography

Several areas of forensic science use the technique of gas chromatography, ranging from fire analysis to the investigation of fraudulent food and perfumes. Covering the essentials of this powerful analytical technique, Forensic Applications of Gas Chromatography explains the theory and shows applications of this knowledge to various realms of foren

Fundamentals of Analytical Toxicology

Dawling, S., Essex, E.G., Ward, N. and Widdop, B. (1990b) Gas chromatographic measurement of cocaine in serum, plasma and whole ... Grob, K. (2001) Split and Splitless Injection for Quantitative Gas Chromatography: Concepts, Processes, ...

Fundamentals of Analytical Toxicology

The analytical toxicologist may be required to detect, identify, and in many cases measure a wide variety of compounds in samples from almost any part of the body or in related materials such as residues in syringes or in soil. This book gives principles and practical information on the analysis of drugs and poisons in biological specimens, particularly clinical and forensic specimens. After providing some background information the book covers aspects of sample collection, transport, storage and disposal, and sample preparation. Analytical techniques - colour tests and spectrophotometry, chromatography and electro­phoresis, mass spectrometry, and immunoassay ? are covered in depth, and a chapter is devoted to the analysis of trace elements and toxic metals. General aspects of method implementation/validation and laboratory operation are detailed, as is the role of the toxicology laboratory in validating and monitoring the performance of point of care testing (POCT) devices. The book concludes with reviews of xenobiotic absorption, distribution and metabolism, pharmacokinetics, and general aspects of the interpretation of analytical toxicology results. A clearly written, practical, integrated approach to the basics of analytical toxicology. Focuses on analytical, statistical and pharmacokinetic principles rather than detailed applications. Assumes only a basic knowledge of analytical chemistry. An accompanying website provides additional material and links to related sites. Written by an experienced team of authors,Fundamentals of Analytical Toxicology is an invaluable resource for those starting out in a career in analytical toxicology across a wide range of disciplines including clinical and forensic science, food safety, and pharmaceutical development. Praise from the reviews: ?This is an ambitious effort to describe in detail the many and varied aspects of the science of toxicological analysis. The 17 chapters cover every foreseeable aspect, from specimen collection through analytical techniques and quality control to pharmacological principles and interpretation of results. The authors bring together a great deal of experience in the field and have succeeded admirably in achieving their goal: "to give principles and practical information on the analysis of drugs, poisons and other relevant analytes in biological specimens...". The book is very readable and quite up-to-date, and contains many illustrative figures, charts and tables. Both the student and the practicing professional would do well to study this material carefully, as there is something here for every conceivable level of interest.? Review from Randall Baselt "This text comes highly recommended for any analytical toxicology trainee." The Bulletin of the Royal College of Pathologists ?Overall, this book provides a comprehensive, thorough, clear, up to date and practical treatment of analytical toxicology at a high standard. Understanding of the text is enhanced by the use of many illustrations. Specifications, guidelines, and methods are highlighted in grey background ?Boxes?. The many and up to date literature references in each chapter demonstrate the authors? thorough work and permit easy access to deeper information. Therefore this book can be highly recommended as a valuable source of knowledge in analytical toxicology both as an introduction and for the advanced reader.? GTFCh Bulletin ?Toxichem + Krimtech?, May 2008 (translated, original review in German) ?Many toxicologists will add this important reference to their libraries because it competently fills a need ...? International Journal of Toxicology ?The book is very well illustrated, easy to understand and pleasant to read, and contains a wealth of dedicated information.? International Journal of Environmental Analytical Chemistry

The Troubleshooting and Maintenance Guide for Gas Chromatographers

These references are recommended for more detailed explanations and discussions of gas chromatographic theory and practice. ... K. Grob: Split and Splitless Injection for Quantitative Gas Chromatography, 4th edition. Wiley-VCH (2001).

The Troubleshooting and Maintenance Guide for Gas Chromatographers

This fourth edition of the classic guide for every user of gas chromatographic instrumentation is now updated to include such new topics as fast GC using narrow, short columns, electronic pressure control, and basic aspects of quantitative gas chromatography. The author shares his many years of experience in technical support for gas chromatography users, addressing the most common problems, questions and misconceptions in capillary gas chromatography. He structures and presents the material in a concise and practical manner, suitable even for the most inexperienced user without any detailed knowledge of chemistry or chromatography. For lab technicians in chemistry, analytical, food, medicinal and environmental chemists, pharmaceutists.

A Century of Separation Science

Quantitative gas chromatographic analysis of hydrocarbons with capillary column and flame - ionization detector . Anal Chem 33 : 978-982 , 1961 . 96. ... Split and Splitless Injection in Capillary Gas Chromatography .

A Century of Separation Science

A Century of Separation Science presents an extensive overview of the critical developments in separation science since 1900, covering recent advances in chromatography, electrophoresis, field-flow fractionation, countercurrent chromatography, and supercritical fluid chromatography for high-speed and high-throughput analysis.

Chromatography

8. Jennings, W.; Mittlefehldt, E.; Stremple, P. Analytical Gas Chromatography, 2nd Ed.; Academic Press: New York, 1997. 9. Grob, K. Split and Splitless Injection for Quantitative Gas Chromatography: Concepts, ...

Chromatography

Provides students and practitioners with a solid grounding in the theory of chromatography, important considerations in its application, and modern instrumentation. Highlights the primary variables that practitioners can manipulate, and how those variables influence chromatographic separations Includes multiple figures that illustrate the application of these methods to actual, complex chemical samples Problems are embedded throughout the chapters as well as at the end of each chapter so that students can check their understanding before continuing on to new sections Each section includes numerous headings and subheadings, making it easy for faculty and students to refer to and use the information within each chapter selectively The focused, concise nature makes it useful for a modular approach to analytical chemistry courses

Tumor Microenvironment

Grob K. Split and splitless injection for quantitative gas chromatography. 4th ed. New York: Wiley; 2015. p. 1–477. Barry EF. Columns: packed and capillary; column selection in gas chromatography. In: Grob RL, Barry EF, editors.

Tumor Microenvironment

This volume covers the topics presented at the 3rd International Conference on Tumor Microenvironment and Cellular Stress by an international community of researchers. The conference brings together scientists to discuss different cellular and animal models of tumor microenvironment study and identify common pathways that are candidates for therapeutic intervention; stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology (e.g., HIF regulation) and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery; and critically evaluate novel targets for imaging or therapeutic intervention that would be of use to the tumor microenvironment community and pharmaceutical industry.

Split and Splitless Injection in Capillary Gas Chromatography

68 K. Grob and H.P. Neukom , " Pressure and Flow Changes in Vaporizing GC Injectors during Injections and their impact on Split Ratio and Discrimination of Sample Components " , HRC & CC 2 ( 1979 ) 563 . 69 K. Grob Jr. and H.P. Neukom ...

Split and Splitless Injection in Capillary Gas Chromatography