The HLA System

This volume documents our growing understanding of the human major histocompatibility complex.

The HLA System

This volume documents our growing understanding of the human major histocompatibility complex. The application of this information is ever more important as the limits of transplantation continue to be reduced, including the recent success of bone marrow transplantation between unrelated but closely matched individuals. In addition, the need to transfuse platelets in the face of immunologic barriers continues to challenge transfusion services. Thus, the serologic information summarized in this volume is essential for optimal patient care. At the same time, recombinant DNA technology has led to a revolution in our understanding of many aspects of basic biology. Among the advances has been the initial characterization of the structure of some HLA loci. While this will ultimately improve clinical services, constant reference to serologic data is essential so that the powerful new techniques can be applied in the most effective ways. The timing of the First Red Cross International Histocompatibility Workshop is fortunate as it brings together experts from around the world to address the state of the art. We are all grateful to Dr. John Lee and his colleagues for organizing the workshop, and for bringing together in this volume the material to be presented in Beijing during October 17-23, 1990. Leon W. Hoyer, M.D.

The HLA System

The HLAsystem, themajor histocompatibility complexinman, is nowrecognized as playinga majorrolein immune recognition and response. Original studies of the polymorphic alleles ofHLAgenes wereperformed using serologic methods; ...

The HLA System

This volume documents our growing understanding of the human major histocompatibility complex. The application of this information is ever more important as the limits of transplantation continue to be reduced, including the recent success of bone marrow transplantation between unrelated but closely matched individuals. In addition, the need to transfuse platelets in the face of immunologic barriers continues to challenge transfusion services. Thus, the serologic information summarized in this volume is essential for optimal patient care. At the same time, recombinant DNA technology has led to a revolution in our understanding of many aspects of basic biology. Among the advances has been the initial characterization of the structure of some HLA loci. While this will ultimately improve clinical services, constant reference to serologic data is essential so that the powerful new techniques can be applied in the most effective ways. The timing of the First Red Cross International Histocompatibility Workshop is fortunate as it brings together experts from around the world to address the state of the art. We are all grateful to Dr. John Lee and his colleagues for organizing the workshop, and for bringing together in this volume the material to be presented in Beijing during October 17-23, 1990. Leon W. Hoyer, M.D.

The HLA System in Clinical Transplantation

passing sera over insoluble anti-HLA class I monoclonal antibodies (mAbs) prior to the assays to remove HLA class I antigens (Burlingham et al. 1988). An additional approach to detect anti-idiotypic antibodies has been recently ...

The HLA System in Clinical Transplantation

With this book we· want to address young graduate students, clini cians involved in transplantation, and technicians in transplantation immunology laboratories. The volume should give a comprehensive but basic, up to date introduction to the structure, function, and clinical importance of the HLA system. We believe that there is a need for such a survey, and think that the present level of our knowledge is an optimal occasion for publication. A significant number of ques tions have now been resolved, and our knowledge has reached a level of sophistication that provides the basis for additional questions and answers. Although the emphasis of this book is on the role of HLA anti gens in clinical transplantation, their involvement in other clinical contexts is also discussed. The main focus is on the human MHC an tigenic system, but MHC systems in other species are described as they contribute to our understanding of the structural and functional characteristics of HLA antigens. Some important issues related to laboratory techniques are also covered. The contributors have a close affiliation to the field of transplan tation immunology. A majority have even been playing important roles in unraveling the HLA system and its functions. We believe this has contributed significantly to the quality and clinical and practical relevance of the book. As editors, we drew up the principal guidelines and took care that the chapters can be read as separate entities, although this invariably results in some overlapping.

Textbook of Blood Banking and Transfusion Medicine

CHAPTER OUTLINE DISCOVERY OF THE HLA SYSTEM FUNCTIONS OF THE MHC GENE PRODUCTS Genetics and Biochemistry of the HLA Complex HLA Inheritance Nomenclature CLINICAL HLA TESTING The Complement-Dependent Cytotoxicity Test HLA Phenotyping ...

Textbook of Blood Banking and Transfusion Medicine

This comprehensive book on transfusion practices and immunohematology offers concise, thorough guidelines on the best ways to screen donors, store blood components, ensure safety, anticipate the potentially adverse affects of blood transfusion, and more. It begins with the basics of genetics and immunology, and then progresses to the technical aspects of blood banking and transfusion. Chapters are divided into sections on: Basic Science Review; Blood Group Serology; Donation, Preparation, and Storage; Pretransfusion Testing; Transfusion Therapy; Clinical Considerations; and Safety, Quality Assurance, and Data Management. Developed specifically for medical technologists, blood bank specialists, and residents, the new edition conforms to the most current standards of the American Association of Blood Banks (AABB). Expert Opinion essays, written by well-known, frequently published experts, discuss interesting topics of research or new advances in the field. Important terms are defined in the margins of the pages on which they appear, enabling readers to easily check the meaning of an unfamiliar term where it appears in context. Margin notes highlight important concepts and points, remind readers of previously discussed topics, offer an alternative perspective, or refer readers to other sources for further information. Material conforms to the most recent AABB standards for the most accurate, up-to-date information on immunohematology. Advanced concepts, beyond what is required for entry-level practice, are set apart from the rest of the text so readers can easily differentiate between basic and advanced information. A new chapter on Hematopoietic Stem Cells and Cellular Therapy (chapter 19) provides cutting-edge coverage of cellular therapy and its relevance to blood-banking. New content has been added on molecular genetics, component therapy, and International Society of Blood Transfusion (ISBT) nomenclature, as well as the latest information on HIV, hepatitis, quality assurance, and information systems. Coverage of new technologies, such as nucleic acid technology and gel technology, keeps readers current with advances in the field.

The HLA Complex in Biology and Medicine

History of HLA : Ten Recollections . Los Angeles : UCLA Tissue Typing Laboratory 1990 : 121-49 . 7. WHO Nomenclature Committee . Nomenclature for Factors of the HL - A System . Bull Wld Hlth Org 1968 ; 39 : 483-6 . 8.

The HLA Complex in Biology and Medicine

A comprehensive guide to the HLA (Human Leukocyte Antigen) system for immunologists and clinicians, this book contains up-to-date information on the MHC (Major Histocompatibility Complex) and its role in the immune response and in various diseases. The book explores the biological significance and role of the HLA system in organ and haematopoietic stem cell transplantation management. This volume is an invaluable guide to the full spectrum of HLA-related science while also serving as a conceptual and technical resource for those involved in HLA-related research and in clinical or surgical practice. In addition, it will be a primary point of contact for individuals working in other areas who suddenly find that their research is drawing them into the complexities of HLA genetics.

The HLA System

When HLA was recognized as the major histocompatibility system ( MHS ) in man , a similar system , H - 2 had already been known for years in mice [ 106 ] . Since then , a number of other vertebrates has been studied , and in everyone of ...

The HLA System


The HLA System and Multiple Sclerosis

The HLA System and Multiple Sclerosis * † Casper Jersild , MD It is the purpose of this review to describe in more detail some of the aspects of the studies of HLA antigens in patients with multiple sclerosis ( MS ) , and to give a ...

The HLA System and Multiple Sclerosis


Cumulated Index Medicus

TRA - ADE formers Nepal 72 uantiy Nomenclature for factors of the HLA system , update May TAP - associated MHC class Ib protein with a restricted ANALYSIS 1999. WHO Nomenclature Committee for factors of the expression pattern .

Cumulated Index Medicus


An Introduction to Human Disease

Consequently , they were named human leukocyte antigens ( HLA antigens ) , and the human major histocompatibility complex is often called the HLA system . Often the designations HLA complex and HLA antigens and MHC complex and MHC ...

An Introduction to Human Disease

An Introduction To Human Disease, Seventh Edition, Continues To Give Students A Clear, Well-Illustrated, Easy-To-Understand Explanation Of The Structural And Functional Change Associated With Disease. This Text Also Indicates How The Disturbances Cause The Clinical Manifestations Of Various Diseases And Guide Treatment. The Seventh Edition Of This Best-Selling Text Has Been Fully Updated To Include The Latest Disease Information And The Most Current Approaches To Treatment.

Index Medicus

HIV - 1 ENVELOPE PROTEIN GP160 see HIV ENVELOPE PROTEIN GP160 HL - 60 CELLS Nomenclature for factors of the HLA system , update January 2002 . Marsh SG ; Who Nomenclature Committee for Factor of the HLA HIV - 1 INTEGRASE see HIV ...

Index Medicus


Clinical Genetics in Nursing Practice

Although incompatibility in the Rh system is the most important , ABO incompatibility can also cause injury . ... THE HLA SYSTEM Characteristics and Inheritance The HLA ( human leukocyte antigen ) system is the major histocompatibility ...

Clinical Genetics in Nursing Practice

Print+CourseSmart

HLA in Narcolepsy

Introduction Y. HONDA Recent findings that all, or almost all, narcoleptic patients typed for human leukocyte antigen (HLA) are DR2 and DQw1 positive indicate that of all HLA-associated diseases, narcolepsy has by far the strongest ...

HLA in Narcolepsy

The Second International Symposium on Narcolepsy was held at Fairchild Auditorium, Stanford University, on 6-7 July 1985 under the presidency of Drs. William C. Dement and Christian Guillemi nault. It succeeded the First International Symposium on Narco lepsy held in La Grande Motte, France, organized by Pierre Pas souant in July 1975 in commemoration of the 100th anniversary of the publication of Jean B. E. Gelineau's paper which proposed the naming of narcolepsy. At the second narcolepsy symposium, many important research reports on both basic and clinical aspects of narcolepsy were given by investigators from many countries of the world. Audience inter est was particularly attracted by the section on the relationship be tween HLA and narcolepsy, in which recent evidence that almost all narcoleptic patients are HLA-DR2 positive was reported by in vestigators from Japan, England, France, Canada, and the United States. The close relationship between the HLA antigens, hitherto considered as immune-related genetic markers encoded by genes on human chromosome 6, and narcolepsy appeared to open a new approach not only for the research of narcolepsy but also for the mechanism of sleep in general. Publication of all these new findings on the association of HLA and narcolepsy was considered; an outline was worked out and all the groups agreed to prepare a contribution covering the various aspects of this topic.

HIV Molecular Immunology 2001

HLA class I restriction with cytotoxic T-cell lymphocytes (CTL) plays a major role in the immune response to and destruction of virally infected cells. The HLA system has since been found associated with susceptibility or resistance to ...

HIV Molecular Immunology 2001


Basic Applied Concepts of Blood Banking and Transfusion Practices E Book

HUMAn LeUKoCYte AntIGen (HLA) sYsteM AnD PLAteLet AntIGens HUMAN LEUKOCYTE ANTIGENS Refractoriness: unresponsiveness to platelet transfusions because of HLA-specific or plateletspecific antibodies or platelet destruction from fever or ...

Basic   Applied Concepts of Blood Banking and Transfusion Practices   E Book

Make complex blood banking concepts easier to understand with Basic & Applied Concepts of Blood Banking and Transfusion Practices, 5th Edition. Combining the latest information in a highly digestible format, this approachable text helps you easily master all areas of blood banking by utilizing common theory, clinical scenarios, case studies, and critical-thinking exercises. With robust user resources and expanded content on disease testing and DNA, it’s the effective learning resource you need to successfully work in the modern lab. Coverage of advanced topics such as transplantation and cellular therapy, the HLA system, molecular techniques and applications, automation, electronic cross-matching, and therapeutic apheresis make the text more relevant for 4-year MLS/CLS programs. Illustrated blood group boxes provide the ISBT symbol, number, and clinical significance of antibodies at a glance. Robust chapter pedagogy helps break down this difficult subject with learning objectives, outlines, key terms with definitions, chapter summaries, critical thinking exercises, study questions, and case studies. NEW! Completely updated content prepares you to work in today’s clinical lab environment. NEW! Additional information on disease testing covers diseases such as Zika and others of increased importance. NEW! Expanded content on DNA covers the latest developments in related testing. NEW! Enhanced user resources on the Evolve companion website now include expanded case studies, and new animations in addition to the existing review questions and lab manual.

Acta Anatomica

Note on Nomenclature lntroduction Historical Background Components of the HLA System Linkage Relationships of HLA Geographical Variation Homologous Systems in Animals Notes on the Biochemistry of HLA Antigens Biology of the HLA System ...

Acta Anatomica


HLA and Associated Important Diseases

This year marks the 60th anniversary (1954) of the discovery of the human major histocompatibility complex (MHC), or the human leukocyte antigen (HLA) system, by the French Nobel laureate physician Jean Dausset, as well as the 55th ...

HLA and Associated Important Diseases

This year marks the 60th anniversary of HLA discovery by the French Nobel laureate physician Jean Dausset, as well as the 55th anniversary of the identification and naming of the first HLA. Under such circumstances, both basic HLA research and its clinical applications need a new book that comprehensively reflects the latest achievements in the field. Thus, Professor Xi as Editor has contributed to organize international experts in the areas of HLA-related basic research and clinical applications, to unite their knowledge in chapters covering various related topics, and finally to finish the book "HLA and Associated Important Diseases". The book consists of three sections which mainly include basic theoretical and technological developments, several important HLA-associated autoimmune diseases and HLA-associated infectious diseases.

Immunobiology of Organ Transplantation

typing techniques has led to a more reliable HLA typing but has also increased the complexity of the HLA system . Several of the serologically defined HLA antigens can now be subdivided in many different alleles , for instance , HLA ...

Immunobiology of Organ Transplantation

Currently, individuals interested in seeking an in-depth discussion of transplantation immunology must seek individual articles published in several journals, or extrapolate information from various non-transplant immunology textbooks. The purpose of this text is to provide the reader with a single source of information for the basic science of immunobiology of organ transplantation. It is unique that it focuses on immunobiology from the basic research side, with an emphasis on the cellular and molecular levels. The readers will be physicians, scientists, and graduate students interested and engaged in the study of immunology as it relates to allo- and xenotransplantation. This book is designed to be the reference standard for the immunobiology of transplantation.

Immunology Guidebook

NEW COMMITTEE MEMBERS The following individuals have been invited to serve on the WHO Nomenclature Committee for Factors of the HLA System: Daniel Geraghty (Seattle, USA), John Hansen (Seattle, USA), Carolyn Hurley (Washington DC, USA), ...

Immunology Guidebook

The Immunology Guidebook provides an easily accessible text-reference to the more up-to-date and difficult concepts in the complex science of immunology. It aims to demystify basic concepts and specialised molecular and cellular interactions. Its 18 chapters offer a logical and sequential presentation where much of the data is displayed in carefully designed tables. This book is intended for immunology students, researchers, practitioners and basic biomedical scientists. Tables provide a quick reference to ‘difficult to find' immunology data A distillate of the latest information on immunogenetics of the human MHC associated with tissue transplantation Information boxes featurw related web resources

Current Developments in Anthropological Genetics

In contrast the seven highest Fst values for the HLA system (values greater than 0.10) have a mean of 0.130, and a total range of 0.028–0.186. Thus, the ability of Fst to detect differences is to some extent dependent on the nature of ...

Current Developments in Anthropological Genetics

The papers in this volume were presented as part of the University of Kansas Department of Anthropology Distinguished Lecture Program on Anthro pological Genetics. Consecutively, each contributor spent approximately a week on the campus at Lawrence participating in a seminar. The contributors to this volume were not on campus at one time, but visited us on alternating weeks; hence, a symposium-type interchange was not possible between all participants. However, the students and faculty of Kansas University acted as a sounding board. This volume can be considered a companion and continuation of Methods and Theories of Anthropological Genetics, which was based upon a symposium on the state of the art in 1971. This present volume reflects what we consider to be some of the advances and current developments in anthropological genetics since 1973. Emphasis has shifted, to some degree, away from population struc ture analysis (as depicted in Crawford and Workman) to genetic epidemiology. However, population structure still remains a fertile and ongoing area of research with many theoretical questions still remaining unanswered.