RENIN - ANGIOTENSIN SYSTEM * ) GENETICS PHYSIOLOGY basic hospital
and renal replacement therapy in the Great ... of tissue renin - angiotensin Jitary
renal hypouricemia ) Asami T. ANGIOTENSIN - CONVERTING ENZYME systems
The vascular renin - angiotensin system Effects of local renin - angiotensin systems have been implicated in vascular , renal and cardiac tissues . The
physiological effects of Ang II on the vasculature are well characterized , and
Publisher: Elsevier Science Limited
This text reviews recent aspects of the renin-angiotensin system with a focus on the medicinal chemistry of the drugs interfering with this system. It also covers the development of nonpeptide angiotensin II receptor antagonists.
It has been shown before that renin can be synthesized in uterine tissue cultures [
30 ] . PRA can persist after nephrectomy ( 14 ] . The arterial tissue renin - angiotensin system can be stimulated by hemorrhage and ischemia [ 15 ] and
Author: J. Genest
The Clinical Research Institute of Montreal, inaugurated in April 1967, intro duced a new concept of organization of clinical research in teaching medical centers. Adjacent to the Hotel-Dieu Hospital, a major teaching hospital of the University of Montreal, the "professional" or career clinical investigators were grouped under one roof with common auditorium, seminar rooms, instruments rooms, cold rooms, experimental surgical rooms and illustration department, with administration, accounting division and machine shops at the service of the research workers. Besides its large multidisciplinary team working on various aspects of hyper tension, the Institute includes research teams in the following fields: 1) neuro biology and Parkinson's disease, 2) lipids and atherosclerosis, 3) molecular biology, 4) immunochemistry, 5) pituitary polypeptides and proteins, 6) nutrition and 7) clinical pharmacology of new drugs. Research is financed entirely by grants obtained from accredited agencies, mostly from the Medical Research Council of Canada. These grant monies constitute about 50 % of the entire budget of the Institute while the other half for administration, maintenance and physical facilities is financed through the support of the Ministry of Social Affairs of Quebec.
In some patients, these compounds also exert a mild diuretic action, presumably
by lowering the angiotensin II- stimulated production of aldosterone. TISSUE RENIN ANGIOTENSIN SYSTEM (RAS). The major portion (90 to 99 per cent) of ...
Author: Eugene Braunwald
Publisher: W.B. Saunders Company
Category: Cardiovascular system
This two-volume reference on heart disease ranges from examination and circulatory function to diseases of the heart, and broader perspectives on heart disease and cardiologic practice. This edition includes 23 new chapters, covering such topics as coronary heart diseases in women, and thrombosis.
Circulating Renin - Angiotensin System Tissue Renin - Angiotensin System
Kidney Kidney Short - term Ellects Long - term Ellects Sodium and Waler
Reabsorption via Aldosterone Secretion Intraglomerular Hypertension 1 Vessels
Author: Desmond Gareth Julian
Publisher: W B Saunders Company
Category: Emergency medicine
Aimed at professionals in the area of cardiology, this book covers all the topics associated with the management of acute myocardial infarction.
the reproductive tract , there may be distinct tissue reninangiotensin systems
subserving autocrine or paracrine ... Clearly , many questions remain to be
answered about tissue renin - angiotensin systems ; not the least is which factors
REVIEW HYPERACTIVE TISSUE RENIN - ANGIOTENSIN SYSTEMS IN
CARDIOVASCULAR DYSFUNCTION : EXPERIMENTAL EVIDENCE AND
CLINICAL HYPOTHESES . Y. M. Pinto , H. Buikema and W. H. van Gilst
Department of clinical ...
This concept proposes that endogenous renin-angiotensin systems are present
in many local tissues and that these systems exert autocrine and paracrine
influences on local tissue functions, The existence of local renin-angiotensin systems ...
Gene Regulation Angiotensinogen Renin ACE Angiotensin receptor FIGURE 21-
31 The systemic and tissue components of the renin - angiotensin system .
Several tissues , including myocardium , vasculature , kidney , and brain , have
Author: Eugene Braunwald
"[A]ccompanying CD contains additional images and video clips." -- v. 2, p. xv.
Evidence obtained in recent years , however , suggests the existence of
endogenous tissue reninangiotensin systems as well ( 2 - 4 ) . Angiotensin II
formed by these local systems may exert an autocrine influence on the cells in
which it is ...
Puppies with high plasma renin exhibited low brain iso - renin , while brain
enzyme concentration was high in adult dogs ... Studies on the Existence of an
Independent Brain Renin - Angiotensin System : A Model for Extrarenal Tissue
... the injurious process . 37 Cardiac tissue renin - angiotensin system Similarly ,
locally released Ang II may exert more potent effects than the circulating Ang II . It
is known that the heart possesses a tissue renin - angiotensin system of its own .
Author: Stephen G. Ball
First published in 1996. Routledge is an imprint of Taylor & Francis, an informa company.
Rosenblum WI, el-Sabban F, Hirsch PD (1986) Angiotensin delays platelet
aggregation after injury of cerebral ... Dzau VJ (1988) Molecular and
physiological aspects of tissue renin-angiotensin system: emphasis on
Author: W. De Jong
Publisher: Elsevier Science Health Science Division
Hardbound. This volume is a worthy successor to volume 4 by virtue of its focus on the recent conceptual revolution in fundamental hypertension research. Without neglecting the heritage of earlier achievements, it highlights such brilliant breakthroughs in molecular genetics as the creation of transgenic animals as a source of a new pathogenesis of hypertension.A core of (patho)physiological mechanisms operative in experimental hypertension is provided, including several which act to maintain a normotensive state. The volume provides background and technical information on the use of different models of hypertension in a variety of animal species. A wealth of new information regarding the several different complications observed in genetic and other models of hypertension, as well as new animal models dedicated to these aspects, are also presented. Furthermore, new chapters addressing genotyping and the use of transgenics in hypertension are included.
From these theories , the concept of an integrated but distinct tissue renin - angiotensin system has recently evolved . The idea that angiotensin II in the
vascular wall is produced locally , and not delivered by the systemic circulation ,
This has gained additional interest due to the discovery of local tissue reninangiotensin systems in addition to the classical hormonal system . The
existence of such intrinsic renin - angiotensin systems has now been confirmed
by a number of ...
THE RENIN - ANGIOTENSIN SYSTEM Contemporary schemes consider this
systemic reninangiotensin system to be critical to the ... Eventually , these tissue renin - angiotensin systems predominate in maintaining chronic RVH . ' Renin
Author: Bruce L. Gewertz
Publisher: W B Saunders Company
A detailed and sophisticated book covering the basics of the aorta and its branches. This new book presents the full range of aortic pathology focusing on the most current surgical and non-surgical treatment options. With extensive contributions from nationally recognized experts, this comprehensive text provides clear, in-depth analysis of clinical expertise in the subject. Covers all branches and diseases - including renal, mesenteric, aortic occlusive, and aneurysmal disease - for definitive reference in one volume. Combines pathophysiology and diagnosis with technical instruction on mesenteric revascularization options, treatment of graft infection, treatment of aortic developmental anomalies, and more, allowing surgical care to be tailored to the individual patient. Follows a cohesive, practice-tested approach, with each section authored by authorities from a single distinguished medical center.
Tissue Renin - Angiotensin Systems by Michael Bader P The renin - angiotensin
eptide hormones with con effects of angiotensin II are attribsystem is a major
siderable impact on cardio uted to the AT - 1 receptor . vascular regulation and
In hypertensive pregnancies the renin - aldosterone system is found to be
suppressed as reflected by decreased levels of aldosterone and ... The
distribution of angiotensin II type 1 receptors , and the tissue renin - angiotensin systems . Mol .
Author: G. Creatsas
This volume explores the recent advances in basic research on the gynecological issues facing young women, and how they apply clinically. Topics examined include neuroendocrinology of the menstural cycle; the endocrinolgy of implantation; prenatal diagnosis; the endocrinology of human gestation and parturition; molecular biology and genetics relative to the estrogen receptor, ovarian dysfunction and gynecologic cancer; perinatal care in maternal and fetal well being; obesity and the polycstic ovarian syndrome; anemia and pregnancy; oral contraceptives and their effects on arteries and veins; the estrogen-deficiency syndrome; osteoporosis in young women; endoscopic surgery; sexually transmitted diseases in common practice; and fertility potential in young women.