Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk

This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations.

Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk

The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never theless, the potential hazards of many chemicals have been identi fied by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the re quirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investiga tions are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests.

Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk

This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations.

Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk

The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never theless, the potential hazards of many chemicals have been identi fied by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the re quirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investiga tions are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests.

Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk

A. KNOWN HUMAN INCREASED INCIDENCE OF EXPOSURE T0 CANNOT BE MEASURED HERITABLE GENETIC MUTAGEN - - - - ---> DISEASE IN HUMANS INTERSPECIES ... A potential use for genetic toxicity tests in quantitative mutagenic risk assessment.

Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk

The magnitude of the threat to the human genetic material posed by environmental agents has not as yet been fully determined. Never theless, the potential hazards of many chemicals have been identi fied by studies on lower organisms. However, too little is known regarding the comparability or lack of it between the metabolic pathways available in such organisms and those in man. Although at present there is great public concern for what is considered by some as the excessive use of laboratory animals in toxicological testing, it seems clear that the usage of mammalian systems may be deemed necessary. It has been proposed that cell culture systems might suffice to meet this need, however, such approaches cannot match the complexity of physiological occurances that are present in the intact animal. For studies of genetic effects, some non-invasive human test systems are presently available. These do not, however, meet the re quirements for extensive laboratory studies. In order to assess the risks to humans of environmental factors such laboratory investiga tions are essential. Therefore, for the forseeable future reliance on experiments using laboratory animals will be necessary. This Volume, which contains the proceedings of a workshop which was held at the National Institute of Environmental Health Sciences, March 29-31, 1982, explores the existing methodologies and their utility for risk estimations. It covers the most well developed human systems, as well as the most widely used animal tests.

Aneuploidy Induction and test systems

Russell LB, Selby PB, von Halle E, Sheridan W, Valcovic L: The mouse specific-locus test with agents other than ... Sheridan W (eds): "Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk.

Aneuploidy  Induction and test systems


Technologies for detecting heritable mutations in human beings

Jackson, E. R., J. R., III, and Voytek, P., “Some Research Needs To Support Mutagenicity Risk Assessments From Whole Mammal Studies, ” Utilization of Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk, ...

Technologies for detecting heritable mutations in human beings


Perspectives on Genetics

LYON , M. F. , 1986 Male sterility of the mouse t - complex is due to homozygosity of the distorter genes . ... In : Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk , Edited by F. J. ...

Perspectives on Genetics

For more than ten years, the distinguished geneticists James F. Crow and William F. Dove have edited the popular “Perspectives” column in Genetics, the journal of the Genetics Society of America. This book, Perspectives on Genetics, collects more than 100 of these essays, which cumulatively are a history of modern genetics research and its continuing evolution.

National Toxicology Program Annual Report for Fiscal Year

In : Workshop on Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk , F. deSerres , and W. Sheridan , ( Eds . ) , ( Plenum Corp. , New York ) , pp . 267-278 .

National Toxicology Program Annual Report for Fiscal Year


Annual Plan for Fiscal Year

tecting induced heritable gene mutations in mammals . The objectives of this project are to evaluate chemicals of environmental significance for their hazard potential as germ cell mutagens using the mouse as an in vivo mammalian model ...

Annual Plan for Fiscal Year


Health Effects of Exposure to Low Levels of Ionizing Radiation

Pp. 135-167 in Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk, F. J. deSerres and W. Sheridan, eds. New York: Plenum. Ro87 Russell, L. B., and E. M. Rinchik. 1987.

Health Effects of Exposure to Low Levels of Ionizing Radiation

This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

New Trends in Genetic Risk Assessment

In “Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk“ (F. J. de Serres and W. Sheridan, eds), pp. 241—258, Plenum, New York. Searle, A. G. and Edwards, J. H. (1986). J. Med. Genet.

New Trends in Genetic Risk Assessment

New Trends in Genetic Risk Assessment is based on the Fifth International Round Table of the Rhône-Poulenc Santé Foundation, held in Nice 1987. The conference was an attempt to review the latest theories and mechanisms stipulated for the various aspects of genotoxicity; it was above all an open forum to discuss the new trends, the new tests, and the new battery of tests for assessing the genetic risk of chemicals and especially drugs. This volume is actually not a proceedings of the meeting but a monograph specially edited to report the reviews which were presented and the discussions which took place; it was designed to provide a better understanding of the knowledge obtained in the most recent years and to help in the practical choice of approaches or tests for the prediction of the various forms of genotoxicity. The main subjects of this review concern molecular analysis of mutagenesis, detection of DNA damage, gene mutation, clastogenesis, aneuploidy, and germ cells. Each theme is preceded by a short overview summarizing the state of the art and the contributions of each author. Finally, special attention was given to the personal views of some leading toxicologists as to the battery of tests presently available or recommended.

Issues and Reviews in Teratology

Applications in genetic risk estimation of data on the induction of dominant skeletal mutations in mice, in: Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk, F. J. de Serres and W.

Issues and Reviews in Teratology

Why Efforts to Expand the Meaning of "Teratogen" Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline.

Genetics Abstracts

7026 - G17 Rolation of mouse specific - locus tests to other mutagenicity tests and to risk estimation . Presented at Workshop on Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk ...

Genetics Abstracts


Fundamentals of Genetic Epidemiology

In Sheridan W, de Serres JF (eds), Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk. New York, Plenum Press, pp 71—93. Neel JV, Satoh K, Goriki M, et a1 (1986).

Fundamentals of Genetic Epidemiology

With continued progress in mapping and sequencing of the human genome, and increasing recognition of the role of genes in disease etiology, there is a need for a more sophisticated approach to the investigation of the causes of complex chronic diseases. This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease etiology. After a brief historical overview of genetics and epidemiology and their gradual rapprochement, the authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations. They describe fundamental research strategies of genetic epidemiology including population and family studies. Among the former are the study of the distribution of genetic traits and the role of nonspecific genetic indicators (such as inbreeding and admixture) in the occurrence of diseases. Among the latter are the analysis of familial aggregation of disease and its causes by epidemiologic methods as well as techniques of formal genetic analysis (variance components, segregation and linkage analysis). Finally, the authors discuss the increasing applications of genetic epidemiology in preventive medicine, public health surveillance, and the emerging ethical issues regarding use of genetic information in society.

Human Health and the Environment

In : Utilization of Mammalian specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk . F.J. de Serres and W. Sheridan , Editors . Plenum Press , New York , NY , p . 241 . Schardein , J.L. ( 1983 ) . Teratogenic Risk ...

Human Health and the Environment


Human Health and the Environment

In : Utilization of Mammalian specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk . F.J. de Serres and W. Sheridan , Editors . Plenum Press , New York , NY , p . 241 . Schardein , J.L. ( 1983 ) . Teratogenic Risk ...

Human Health and the Environment


National Library of Medicine Current Catalog

Utilization of mammalian specific locus studies in hazard evaluation and estimation of genetic risk / edited by Frederick J. de Serres and William Sheridan . New York : Plenum Press , c1983 . ix , 341 p . : ill .

National Library of Medicine Current Catalog


Scientific Directory and Annual Bibliography

3961 . and Sheridan , W. , ( Eds . ) : Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk . New York , Plenum , 1983 , 341 pp . 3962. Sheridan , W .: The detection of induced recessive ...

Scientific Directory and Annual Bibliography

Each issue lists papers published during the preceding year.

Scientific Directory and Annual Bibliography

3961 . and Sheridan , W. , ( Eds . ) : Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk . New York , Plenum , 1983 , 341 pp . Stephen C. Bondy , Ph.D. * Jau - Shyong Hong , Ph.D. Teruzo ...

Scientific Directory and Annual Bibliography


Advances in Human Genetics 15

A novel approach to testing for induced point mutations in mammals, Humangenetik 26:231–243. ... in: Utilization of Mammalian Specific Locus Studies in Hazard Evaluation and Estimation of Genetic Risk (F. J. de Serres and W. Sheridan, ...

Advances in Human Genetics 15